To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]
, 2015 Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH +2 more
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Scientific Reports, 2023 Adenosine-to-inosine RNA editing is a process mediated by adenosine deaminases that act on the RNA (ADAR) gene family. It has been discovered recently as an epigenetic modification dysregulated in human cancers.
Nanako Hata +19 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2023 Background ADAR1, the major enzyme for RNA editing, has emerged as a tumor-intrinsic key determinant for cancer immunotherapy efficacy through modulating interferon-mediated innate immunity.
Jie Wu +8 more
doaj +1 more source
Proteins that contain a functional Z-DNA-binding domain localize to cytoplasmic stress granules [PDF]
, 2013 Long double-stranded RNA may undergo hyper-editing by adenosine deaminases that act on RNA (ADARs), where up to 50% of adenosine residues may be converted to inosine.
Ng, Siew Kit +3 more
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Population and allelic variation of A-to-I RNA editing in human transcriptomes. [PDF]
, 2017 BackgroundA-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Demirdjian, Levon +6 more
core +2 more sources
Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. [PDF]
, 2016 Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA. In humans, ADAR1 and ADAR2 catalyze this modification and their malfunction correlates with disease. Recently our laboratory reported crystal structures of the
Beal, Peter A, Wang, Yuru
core +1 more source
An essential role of adenosine deaminase acting on RNA 1 in coeliac disease mucosa
Frontiers in Immunology, 2023 Background and aimType I interferons (IFNs) are highly expressed in the gut mucosa of celiac disease (CD) gut mucosa and stimulates immune response prompted by gluten ingestion, but the processes that maintain the production of these inflammatory ...
Davide Di Fusco +14 more
doaj +1 more source
Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site [PDF]
, 2002 RNA editing by members of the ADAR (adenosine deaminase that acts on RNA) enzyme family involves hydrolytic deamination of adenosine to inosine within the context of a double-stranded pre-mRNA substrate.
Collins, Cynthia H. +2 more
core +1 more source
Crystal structure of a poxvirus-like zalpha domain from cyprinid herpesvirus 3 [PDF]
, 2013 Zalpha domains are a subfamily of the winged helix-turn-helix domains sharing the unique ability to recognize CpG repeats in the left-handed Z-DNA conformation.
Athanasiadis, Alekos +8 more
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Structural basis for Z-DNA binding and stabilization by the zebrafish Z-DNA dependent protein kinase PKZ [PDF]
, 2013 The RNA-dependent protein kinase PKR plays a central role in the antiviral defense of vertebrates by shutting down protein translation upon detection of viral dsRNA in the cytoplasm. In some teleost fish, PKZ, a homolog of PKR, performs the same function,
Athanasiadis, A. +2 more
core +1 more source