Results 101 to 110 of about 4,066 (198)

Dimerization of ADAR2 is mediated by the double-stranded RNA binding domain [PDF]

RNA, 2006
Members of the family of adenosine deaminases acting on RNA (ADARs) can catalyze the hydrolytic deamination of adenosine to inosine and thereby change the sequence of specific mRNAs with highly double-stranded structures. The ADARs all contain one or more repeats of the double-stranded RNA binding motif (DRBM).
Poulsen, Hanne, Jorgensen, Rasmus, Heiding, Anders, Nielsen, Finn C., Bonven, Bjarne Juul, Jensen, Jan Egebjerg   +5 more
openaire   +3 more sources

Involvement of RNA-editing enzyme and multi-factor to motor neuron death in patients with sporadic amyotrophic lateral sclerosis [PDF]

, 2012
科学研究費助成事業(科学研究費補助金)研究成果報告書：基盤研究(C)2009-2011課題番号 ...
TAKUMA HIROSHI, 詫間 浩
core  

Current developments in gene therapy for amyotrophic lateral sclerosis. [PDF]

, 2015
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a devastating adult neurodegenerative disorder characterized by motor neuron degeneration and death around 3 years from onset.
Alrafiah, A.R., Azzouz, M., Herranz-Martín, S., Scarrott, J.M., Shaw, P.J.   +4 more
core   +1 more source

PP2A Promotes the Symmetric Division of MUC1‐Dominant Cancer Stem‐Like Cells in Small Cell Lung Cancer

Advanced Science, Volume 12, Issue 25, July 3, 2025.
During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li, Xinran Dong, Kexing Gao, Yiyang Wang, Min Li, Huayun Deng, Shuangyu Ma, Yaping Lv, Wei Jin, Quanfu Li, Yuming Wang, Xiaodong Liao, Kangjing Bian, Aiwu Zhou, Chengping Hu, Lei Huang   +15 more
wiley   +1 more source

Evaluation of Engineered CRISPR-Cas-Mediated Systems for Site-Specific RNA Editing

Cell Reports, 2020
Summary: Site-directed RNA editing approaches offer great potential to correct genetic mutations in somatic cells while avoiding permanent off-target genomic edits.
Ryan J. Marina, Kristopher W. Brannan, Kevin D. Dong, Brian A. Yee, Gene W. Yeo   +4 more
doaj   +1 more source

The contribution of Alu exons to the human proteome. [PDF]

, 2016
BackgroundAlu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important ...
Jiang, Peng, Lam, Maggie PY, Lin, Lan, Lu, Zhi-Xiang, Park, Juw Won, Ping, Peipei, Wang, Jinkai, Xing, Yi   +7 more
core   +1 more source

Decoding RNA–Protein Interactions: Methodological Advances and Emerging Challenges

Advanced Genetics, Volume 6, Issue 2, June 2025.
This review provides a comprehensive comparison of RNA‐ and protein‐centric methodologies for investigating RNA–protein interactions, emphasizing their respective advantages, limitations, and suitable applications. It highlights recent technological innovations, outlines strategic method selection criteria, and addresses key challenges.
Wenkai Yi, Jian Yan
wiley   +1 more source

ADAR2 editing enzyme is a novel human immunodeficiency virus-1 proviral factor

Journal of General Virology, 2011
The adenosine deaminases acting on RNA (ADAR) enzymes catalyse conversion of adenosine to inosine in dsRNA. A positive effect of ADAR1 on human immunodeficiency virus type 1 (HIV-1) replication has recently been reported. Here, we show that another ADAR enzyme, ADAR2, positively affects the replication process of HIV-1.
Doria, M, Tomaselli, S, Neri, F, CIAFRE', SILVIA ANNA, FARACE, MARIA GIULIA, MICHIENZI, ALESSANDRO, Gallo, A.   +6 more
openaire   +4 more sources

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis

Genome Biology, 2017
Background Adenosine-to-inosine (A-to-I) editing of dsRNA by ADAR proteins is a pervasive epitranscriptome feature. Tens of thousands of A-to-I editing events are defined in the mouse, yet the functional impact of most is unknown. Editing causing protein
Jacki E. Heraud-Farlow, Alistair M. Chalk, Sandra E. Linder, Qin Li, Scott Taylor, Joshua M. White, Lokman Pang, Brian J. Liddicoat, Ankita Gupte, Jin Billy Li, Carl R. Walkley   +10 more
doaj   +1 more source

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing

Cell Reports, 2020
Summary: Adenosine-to-inosine RNA editing is catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes that deaminate adenosine to inosine. Although many RNA editing sites are known, few trans regulators have been identified.
Emily C. Freund, Anne L. Sapiro, Qin Li, Sandra Linder, James J. Moresco, John R. Yates, III, Jin Billy Li   +6 more
doaj   +1 more source