Results 111 to 120 of about 1,976 (156)

A‐to‐I‐Edited miR‐1304‐3p Inhibits Glycolysis and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inactivating Wnt5a/ROR2 Signaling

Molecular Carcinogenesis, Volume 64, Issue 3, Page 552-564, March 2025.
ABSTRACT A‐to‐I RNA editing is a pervasive mechanism in the human genome that affects the regulation of gene expression and is closely associated with the pathogenesis of numerous diseases. This study elucidates the regulatory mechanism of A‐to‐I edited miR‐1304‐3p in esophageal squamous cell carcinoma (ESCC). Western blot, immunohistochemistry, and RT‐
Peng Chen, Hang Zhou, Xian Yang, Yuzhen Zheng, Yujie Chen, Peiyuan Wang, Hao He, Shuoyan Liu, Feng Wang   +8 more
wiley   +1 more source

A-to-I editing in human miRNAs is enriched in seed sequence, influenced by sequence contexts and significantly hypoedited in glioblastoma multiforme

Scientific Reports, 2017
Editing in microRNAs, particularly in seed can significantly alter the choice of their target genes. We show that out of 13 different human tissues, different regions of brain showed higher adenosine to inosine (A-to-I) editing in mature miRNAs.
Deepanjan Paul, Ashis Narayan Sinha, Arjun Ray, Megha Lal, Subhashree Nayak, Anchal Sharma, Bharati Mehani, Debasish Mukherjee, Saurabh V. Laddha, Ashish Suri, Chitra Sarkar, Arijit Mukhopadhyay   +11 more
doaj   +1 more source

Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage [PDF]

, 2013
Adenosine to inosine (A > I) RNA editing, which is catalyzed by the ADAR family of proteins, is one of the fundamental mechanisms by which transcriptomic diversity is generated.
Cattenoz, Pierre B., Mattick, John S., Taft, Ryan J., Westhof, Eric   +3 more
core   +2 more sources

Genome-wide analysis of consistently RNA edited sites in human blood reveals interactions with mRNA processing genes and suggests correlations with cell types and biological variables

BMC Genomics, 2018
Background A-to-I RNA editing is a co−/post-transcriptional modification catalyzed by ADAR enzymes, that deaminates Adenosines (A) into Inosines (I).
Edoardo Giacopuzzi, Massimo Gennarelli, Chiara Sacco, Alice Filippini, Jessica Mingardi, Chiara Magri, Alessandro Barbon   +6 more
doaj   +1 more source

REPAIR - new tool for RNA editing with Cas13 [PDF]

, 2018
Istraživači su nedavno razvili alat REPAIR koji se sastoji od spojene katalitičke domene deaminaze ADAR i katalitički mrtvog Cas13b, iz obitelji proteina Cas13.
Majsec, Petra
core   +2 more sources

Identification of evolutionarily meaningful information within the mammalian RNA editing landscape [PDF]

, 2014
A large comparative genomic sequence study has determined the extent of conservation between RNA editing sites within the mammalian evolutionary tree.
Robert A Reenan, Yiannis A Savva
core   +2 more sources

Characteristics of transposable element exonization within human and mouse [PDF]

, 2010
Insertion of transposed elements within mammalian genes is thought to be an important contributor to mammalian evolution and speciation. Insertion of transposed elements into introns can lead to their activation as alternatively spliced cassette exons ...
A Athanasiadis, A Corvelo, A Gerber, A Goren, A Levy, A Magen, A Nekrutenko, A Resch, AFA Smit, Agnes Hotz-Wagenblatt, B Giardine, B Mersch, BR Graveley, Britta Mersch, C Liu, D Karolchik, D Labuda, DD Kim, E Kim, ES Lander, EY Levanon, G Ast, G Lev-Maor, G Lev-Maor, Gil Ast, H Xie, Ilya Ruvinsky, J Hull, J Jurka, J Jurka, JO Kriegs, JO Yang, JP Nemes, K Nakabayashi, KP Kister, L Lin, L Lin, M Amit, M Blow, M Krull, M Moller-Krull, M Roy, M Sironi, M Sironi, MA Batzer, MD Koob, N Gal-Mark, N Gal-Mark, N Sela, NH Gehring, Noa Sela, O Ram, P Deininger, PL Deininger, R Cordaux, R Sorek, R Sorek, R Sorek, RA Gibbs, RE Mills, RH Waterston, RM Kuhn, RT Hillman, S He, S Schwartz, SK Ng, SS Singer, ST Sherry, T Kwan, T Kwan, VV Kapitonov, W Makalowski, WJ Kent, WL Chen, WS Lo, XH Zhang, Y Xing, YF Chang   +77 more
core   +4 more sources

Aberrant alternative splicing pattern of ADAR2 downregulates adenosine-to-inosine editing in glioma

Oncology Reports, 2015
Adenosine-to-inosine (A-to-I) RNA editing is the most common type of RNA editing in mammals, and is catalyzed by adenosine deaminases acting on RNA (ADARs). ADAR2 is the main enzyme responsible for A-to-I editing in humans, and A-to-I underediting at the glutamine (Q)/arginine (R) site of the glutamate receptor subunit B (GluR-B) is associated with the
Zhaohui, Li, Yu, Tian, Nan, Tian, Xingli, Zhao, Chao, Du, Liang, Han, Haishan, Zhang   +6 more
openaire   +3 more sources

胶质瘤中RNA编辑酶ADAR2,ADAR3 mRNA表达及意义

Zhongguo shiyan zhenduanxue, 2006
目的观察不同恶性程度的胶质瘤细胞中RNA编辑酶ADAR2（RED1）,ADAR3（RED2）mRNA水平的表达。方法对原代培养的正常人脑胶质细胞和胶质瘤细胞SHG-44,U-251,BT-325,应用ADAR2,ADAR3全长序列合成引物及合成的特异引物,用逆转录PCR及图像分析法检测ADAR2,ADAR3 mRNA水平的表达。ADAR基因表达水平用基因/β-肌动蛋白（-βactin）灰度比值表示。结果ADAR2在正常人脑胶质细胞中表达极弱,在低恶性度的胶质瘤SHG-44细胞中呈弱表达 ...
田宇, 潘玉琢, 杜超, 高俊, 李桂林, 李桂英, 王任直   +6 more
doaj  

RNA modifications, alternative splicing and circular RNA landscape in the mouse brain: inosine and beyond

Scientific Reports
RNA modifications in the brain can be essential for regulating the transcriptome and brain function. Our study unveils the landscape of different RNA modifications associated with splicing within the mouse brain.
Erika Larrea, Maitena Tellaetxe-Abete, Yan Peng, Yujie Zhang, Shuangshuang Feng, Kaidong Lu, Liang Xue, Taisuke Nakahama, Yukio Kawahara, Magdalena J. Koziol   +9 more
doaj   +1 more source