Results 121 to 130 of about 1,976 (156)
A survey on cellular RNA editing activity in response to Candida albicans infections
BMC Genomics, 2018 Background Adenosine-to-Inosine (A-to-I) RNA editing is catalyzed by the adenosine deaminase acting on RNA (ADAR) family of enzymes, which induces alterations in mRNA sequence.
Yaowei Huang +7 more
doaj +1 more source
The role of the Prader-Willi syndrome critical interval for epigenetic regulation, transcription and phenotype [PDF]
, 2018 Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder caused by loss of expression of the paternally inherited genes on chromosome 15q11.2-q13. However, the core features of PWS have been attributed to a critical interval (PWS-cr) within the 15q11.
Isles, Anthony, Zahova, Simona
core +2 more sources
GluA2 is rapidly edited at the Q/R site during neural differentiation in vitro
Frontiers in Cellular Neuroscience, 2015 The majority of AMPA receptors in the adult brain contain GluA2 subunits, which can be edited at the Q/R site, changing a glutamine to an arginine within the ion pore.
Svenja ePachernegg +10 more
doaj +1 more source
RNA recognition by double-stranded RNA binding domains: a matter of shape and sequence [PDF]
, 2018 The double-stranded RNA binding domain (dsRBD) is a small protein domain of 65-70 amino acids adopting an αβββα fold, whose central property is to bind to double-stranded RNA (dsRNA).
Allain, Frédéric +2 more
core
ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity. [PDF]
, 2016 It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the
Dickman, DK +3 more
core
Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2010 目的探讨RNA编辑酶在结直肠癌组织标本中的表达及其意义。方法收集临床结直肠癌组织标本及癌周正常组织标本12例,应用RT-PCR法检测RNA编辑酶ADAR1、ADAR2在结直肠癌组织及癌旁正常组织标本中的表达并分析。结果编辑酶ADAR1在人结直肠癌组织及癌旁组织中未见明显表达,而编辑酶ADAR2在结直肠癌组织及结直肠癌旁组织中阳性表达,并在结直肠癌组织中表达增强（癌组织中阳性表达率为75%,癌旁组织阳性表达率为41.7 ...
张广 +4 more
doaj
The role of RNA editing in cancer development and metabolic disorders [PDF]
, 2018 Kung, Che-Pei +2 more
core +2 more sources
Hairpin RNA: a secondary structure of primary importance [PDF]
, 2018 .: An RNA hairpin is an essential secondary structure of RNA. It can guide RNA folding, determine interactions in a ribozyme, protect messenger RNA (mRNA) from degradation, serve as a recognition motif for RNA binding proteins or act as a substrate for ...
Cara, A., Svoboda, P.
core
Genome BiologyRNA editing by adenosine deaminases acting on RNA (ADARs) is an essential cellular process performed by three enzymes in mammals: ADAR1-p150, ADAR1-p110, and ADAR2, demonstrating different target specificity and selectivity.
Maike Herrmann +8 more
doaj +1 more source