Results 11 to 20 of about 6,398,385 (224)

Autorecoding A-to-I RNA editing sites in theAdargene underwent compensatory gains and losses in major insect clades [PDF]

RNA, 2023
As one of the most prevalent RNA modifications in animals, adenosine-to-inosine (A-to-I) RNA editing facilitates the environmental adaptation of organisms by diversifying the proteome in a temporal–spatial manner. In flies and bees, the editing enzyme Adar has independently gained two different autorecoding sites that form an autofeedback loop ...
Yuange Duan, Ling Ma, Fan Song, Li Tian, Wanzhi Cai, Hu Li   +5 more
semanticscholar   +5 more sources

ADAR-mediated regulation of PQM-1 expression in neurons impacts gene expression throughout C. elegans and regulates survival from hypoxia

PLOS Biology, 2023
The ability to alter gene expression programs in response to changes in environmental conditions is central to the ability of an organism to thrive. For most organisms, the nervous system serves as the master regulator in communicating information about the animal’s surroundings to other tissues. The information relay centers on signaling pathways that
Ananya Mahapatra, Alfa Dhakal, Aika Noguchi, Pranathi Vadlamani, Heather A. Hundley   +4 more
semanticscholar   +6 more sources

ADAR Gene [PDF]

Definitions, 2020
The ADAR1 protein is involved in the control of the innate immune response, which is the immune system's early response to foreign invaders (pathogens).

semanticscholar   +3 more sources

Adar contributes to genome integrity by regulating R-loop homeostasis in Drosophila [PDF]

BMC Biology
Background Adenosine deaminase acting on RNA (Adar) is a critical enzyme involved in post-transcriptional epigenetic regulation through adenosine-to-inosine (A-to-I) RNA editing.
Xuedi Zhang, Hongyun Liu, Ju Peng, Guangbin Wang, Xiangyu Wu, Shuai Li, Jie Zheng, Qianwen Sun, Guanjun Gao   +8 more
doaj   +3 more sources

Aicardi-Goutières syndrome type 6: report of ADAR variant and clinical outcome after ruxolitinib treatment in the neonatal period [PDF]

Pediatric Rheumatology Online Journal
Background Aicardi-Goutières Syndrome is a monogenic type 1 interferonopathy with infantile onset, characterized by a variable degree of neurological damage.
Alba Gabaldon-Albero, Carla Martin-Grau, Miguel Marti-Masanet , Alejandro Lopez-Jimenez, Roberto Llorens, Beatriz Beseler-Soto, Sergio Martin-Zamora, Berta Lopez, Inmaculada Calvo, Sara Hernandez-Muela, Monica Rosello, Carmen Orellana, Francisco Martinez   +12 more
doaj   +3 more sources

An engineered U7 small nuclear RNA scaffold greatly increases ADAR-mediated programmable RNA base editing [PDF]

Nature Communications
Custom RNA base editing exploiting the human Adenosine Deaminase Acting on RNA (ADAR) enzyme may enable therapeutic gene editing without DNA damage or use of foreign proteins.
Susan M. Byrne, Stephen M. Burleigh, Robert Fragoza, Yue Jiang, Yiannis Savva, Ricky Pabon, Evan Kania, Joseph Rainaldi, Andrew Portell, Prashant Mali, Adrian W. Briggs   +10 more
doaj   +3 more sources

An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer [PDF]

Nucleic Acids Research, 2017
Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA) (ADAR), occurs predominantly in the 3' untranslated regions (3'UTRs) of spliced mRNA. Here we uncover an unanticipated link between ADARs (ADAR1 and ADAR2) and the expression of target genes undergoing extensive 3'UTR editing. Using METTL7A
Lihua Qi, Yangyang Song, Tim Hon Man Chan, Henry Yang, Chi Ho Lin, Daryl Jin Tai Tay, HuiQi Hong, Sze Jing Tang, Kar Tong Tan, Xi Huang, Jaymie Siqi Lin, Vanessa Hui En Ng, Julien Jean Pierre Maury, Daniel G. Tenen, Leilei Chen   +14 more
openalex   +5 more sources

High doses of siRNAs induce eri-1 and adar-1 gene expression and reduce the efficiency of RNA interference in the mouse [PDF]

Biochemical Journal, 2005
RNAi (RNA interference) is a gene-silencing mechanism that is conserved in evolution from worm to human and has been a powerful tool for gene functional research. It has been clear that the RNAi effect triggered by endogenous or exogenous siRNAs (small interfering RNAs) is transient and dose-dependent.
Jie Hong, Zhikang Qian, Shuiyuan Shen, Taishan Min, Chang Tan, Jianfeng Xu, Yingchun Zhao, Weida Huang   +7 more
openalex   +4 more sources

Induction of 150‐kDa adenosine deaminase that acts on RNA (ADAR)‐1 gene expression in normal T lymphocytes by anti‐CD3‐ε and anti‐CD28 [PDF]

Immunology, 2007
SummaryWe and other investigators have demonstrated up‐regulation of the expression of the RNA‐editing gene 150‐kDa adenosine deaminase that acts on RNA (ADAR1) in systemic lupus erythematosus (SLE) T cells and B cells, peripheral blood mononuclear cells (PBMC), natural killer (NK) cells.
Dama Laxminarayana, Islam Ullah Khan, Kenneth S. O’Rourke, Banabihari Giri   +3 more
openalex   +5 more sources

An RNA editing/binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer [PDF]

, 2016
AbstractAdenosine-to-inosine (A-to-I) editing, catalysed by Adenosine DeAminases acting on double-stranded RNA (dsRNA) (ADAR), occurs predominantly in the 3’ untranslated regions (3’UTRs). Here we uncover an unanticipated link between ADARs (ADAR1 and ADAR2) and the expression of target genes undergoing extensive 3’UTR editing.
Lihua Qi, Yangyang Song, Tim Hon Man Chan, Henry Yang, Chi Ho Lin, Daryl Jin Tai Tay, HuiQi Hong, Jaymie Siqi Lin, Vanessa Hui En Ng, Julien Jean Pierre Maury, Daniel G. Tenen, Leilei Chen   +11 more
openalex   +4 more sources