PLoS Biology, 2023 The ability to alter gene expression programs in response to changes in environmental conditions is central to the ability of an organism to thrive. For most organisms, the nervous system serves as the master regulator in communicating information about ...
Ananya Mahapatra +4 more
openalex +2 more sources
Evaluation of in vitro liver models and non-human primates for predicting ADAR RNA editing efficiency in human liver [PDF]
Scientific ReportsLiver-originated diseases remain a significant global health burden, with limited treatment options available. RNA therapeutics, particularly adenosine deaminase acting on RNA (ADAR)-mediated editing using editing oligonucleotides (EONs) offer a novel ...
Monica Aguila +8 more
doaj +2 more sources
ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity [PDF]
Nature Communications, 2016 Sleep is postulated to offset buildup in net synaptic strength that occurs during waking experience. Here, the authors identify a role for the RNA editing gene Adar in regulating glutamatergic synaptic plasticity and show that disruption in ...
J. E. Robinson +3 more
doaj +2 more sources
RNA editing system: Balancing altruistic antiviral defense and fitness trade-offs in fungi. [PDF]
mLifemLife, Volume 4, Issue 6, Page 597-601, December 2025.
Du Y, Jiang D, Liu H.
europepmc +2 more sources
The conserved protein kinase-A target motif in synapsin of
BMC Neuroscience, 2006 Background Synapsins are abundant synaptic vesicle associated phosphoproteins that are involved in the fine regulation of neurotransmitter release.
Buchner Erich +5 more
doaj +4 more sources
RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells [PDF]
Molecular MetabolismObjective: A longstanding question in type 1 diabetes (T1D) research pertains to the selective loss of β-cells whilst neighboring islet α-cells remain unharmed.
Shani Peleg +12 more
doaj +2 more sources
Pediatric Rheumatology Online JournalBackground Aicardi-Goutières Syndrome is a monogenic type 1 interferonopathy with infantile onset, characterized by a variable degree of neurological damage.
Alba Gabaldon-Albero +12 more
doaj +2 more sources
ADAR1 haploinsufficiency and sustained picornaviral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy [PDF]
mBioSensing of viral double-stranded RNA (dsRNA) by MDA5 triggers abundant but transient interferon-stimulated gene (ISGs) expression. If dsRNA synthesis is made persistent by transgenically expressing a picornaviral RNA-dependent RNA polymerase (RdRp) in ...
Caitlin M. Miller +7 more
doaj +2 more sources
Emerging clinical applications of ADAR based RNA editing. [PDF]
Stem Cells Transl MedRNA editing via adenosine deaminases acting on RNA (ADARs) offers precise and reversible modifications at the RNA level, complementing traditional DNA-targeting therapies.
Rainaldi J, Mali P, Nourreddine S.
europepmc +2 more sources
Gene and RNA Editing: Revolutionary Approaches to Treating Diseases [PDF]
MedCommGene editing and RNA editing technologies are advancing modern medicine by enabling precise manipulation of genetic information at the DNA and RNA levels, respectively. The third‐generation gene editing tools, particularly Clustered regularly interspaced
Jia‐Mei Li +6 more
doaj +2 more sources