A full repertoire of Hemiptera genomes reveals a multi-step evolutionary trajectory of auto-RNA editing site in insect Adar gene [PDF]
RNA Biology, 2023 Adenosine-to-inosine (A-to-I) RNA editing, mediated by metazoan ADAR enzymes, is a prevalent post-transcriptional modification that diversifies the proteome and promotes adaptive evolution of organisms. The Drosophila Adar gene has an auto-recoding site (
Ling Ma +8 more
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Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene [PDF]
EpigeneticsAlthough A-to-I RNA editing leads to similar effects to A-to-G DNA mutation, nonsynonymous RNA editing (recoding) is believed to confer its adaptiveness by ‘epigenetically’ regulating proteomic diversity in a temporospatial manner, avoiding the ...
Caiqing Zheng +6 more
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ADAR Regulates RNA Editing, Transcript Stability, and Gene Expression
Cell Reports, 2013 Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine, which is then recognized as guanosine. To study the role of ADAR proteins in RNA editing and gene regulation, we sequenced and compared the DNA and RNA of human B cells.
Isabel X. Wang +5 more
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Unveiling RNA Editing by ADAR and APOBEC Protein Gene Families [PDF]
Frontiers in Bioscience-LandmarkRNA editing is a crucial post-transcriptional modification that alters the transcriptome and proteome and affects many cellular processes, including splicing, microRNA specificity, stability of RNA molecules, and protein structure.
Alexander Modestov +2 more
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Autorecoding A-to-I RNA editing sites in the Adar gene underwent compensatory gains and losses in major insect clades. [PDF]
RNA, 2023 As one of the most prevalent RNA modifications in animals, adenosine-to-inosine (A-to-I) RNA editing facilitates the environmental adaptation of organisms by diversifying the proteome in a temporal–spatial manner. In flies and bees, the editing enzyme Adar has independently gained two different autorecoding sites that form an autofeedback loop ...
Duan Y +5 more
europepmc +5 more sources
The origin of the ADAR gene family and animal RNA editing. [PDF]
BMC Evol Biol, 2015 ADAR (adenosine deaminase acting on RNA) proteins convert adenosine into inosine in double-stranded RNAs and have been shown to increase gene product diversity in a number of bilaterians, particularly mammals and flies. This enzyme family appears to have evolved from an ADAT (adenosine deaminase acting on tRNA) ancestor, via the addition of a double ...
Grice LF, Degnan BM.
europepmc +7 more sources
Expression Profile and Clinical Relevance of ADAR Family Genes in Head and Neck Squamous Cell Carcinoma. [PDF]
Genes (Basel)Background: ADAR1 (ADAR), ADAR2 (ADARB1), and ADAR3 (ADARB2) are deaminase adenosine RNA-specific enzymes that play a significant role in RNA metabolism. ADAR1 (ADAR) and ADAR2 (ADARB1) catalyze A-to-I editing and ADAR3 (ADARB2) plays a regulatory role. The role of these three genes still remains unknown in head and neck cancers (HNSCC).
Kolenda T +11 more
europepmc +4 more sources
ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity [PDF]
Nature Communications, 2016 Sleep is postulated to offset buildup in net synaptic strength that occurs during waking experience. Here, the authors identify a role for the RNA editing gene Adar in regulating glutamatergic synaptic plasticity and show that disruption in ...
J. E. Robinson +3 more
doaj +2 more sources
Mendelian randomization reveals DNA methylation–related pyroptosis genes associated with psoriasis risk [PDF]
Clinical EpigeneticsBackground Research has indicated a connection between pyroptosis and psoriasis, yet the specific genes involved remain largely unidentified. This study employed Mendelian randomization (MR) to evaluate the potential causal impact of both pyroptosis ...
Wenwu Dong, Cuiping Shi
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