Results 81 to 90 of about 15,493 (211)

Solution structure of the N-terminal dsRBD of Drosophila ADAR and interaction studies with RNA [PDF]

, 2012
Adenosine deaminases that act on RNA (ADAR) catalyze adenosine to inosine (A-to-I) editing in double-stranded RNA (dsRNA) substrates. Inosine is read as guanosine by the translation machinery; therefore A-to-I editing events in coding sequences may ...
Barraud, Barraud, Barraud, Bass, Bhalla, Blaszczyk, Bratt, Bret S.E. Heale, Brunger, Brunger, Burns, Bycroft, Chang, Cho, DeLano, Dominguez, Duss, Eggington, Fierro-Monti, Frédéric H.-T. Allain, Gallo, Gan, Goddard, Graveley, Guntert, Guntert, Herrmann, Herrmann, Higuchi, Hood, Hoopengardner, Keegan, Keegan, Kharrat, Krovat, Laskowski, Lehmann, Leulliot, Lomeli, Maas, Macbeth, Mary A. O’Connell, Nishikura, Palladino, Palladino, Paro, Pierre Barraud, Ramos, Ryter, Saunders, Sommer, Stapleton, Stefl, Stefl, Stefl, Stephens, Valente, Wang, Wu, Yang   +59 more
core   +4 more sources

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, Volume 2, Issue 1, Page 106-129, March 2026.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

ADAR1 Zα domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing

Cell Reports, 2023
Summary: Variants of the RNA-editing enzyme ADAR1 cause Aicardi-Goutières syndrome (AGS), in which severe inflammation occurs in the brain due to innate immune activation.
Xinfeng Guo, Silvia Liu, Yi Sheng, Mazen Zenati, Timothy Billiar, Alan Herbert, Qingde Wang   +6 more
doaj   +1 more source

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

The conserved protein kinase-A target motif in synapsin of Drosophila is effectively modified by pre-mRNA editing

BMC Neuroscience, 2006
Background Synapsins are abundant synaptic vesicle associated phosphoproteins that are involved in the fine regulation of neurotransmitter release.
Buchner Erich, Zars Troy, Werner Ursula, Hoppe Jürgen, Nieratschker Vanessa, Diegelmann Sören   +5 more
doaj   +1 more source

Oligophrenin-1 (OPHN1), a gene involved in X-linked intellectual disability, undergoes RNA editing and alternative splicing during human brain development. [PDF]

PLoS ONE, 2014
Oligophrenin-1 (OPHN1) encodes for a Rho-GTPase-activating protein, important for dendritic morphogenesis and synaptic function. Mutations in this gene have been identified in patients with X-linked intellectual disability associated with cerebellar ...
Sabina Barresi, Sara Tomaselli, Alekos Athanasiadis, Federica Galeano, Franco Locatelli, Enrico Bertini, Ginevra Zanni, Angela Gallo   +7 more
doaj   +1 more source

Modulation of MicroRNA Processing by Dicer via Its Associated dsRNA Binding Proteins

Non-Coding RNA, 2021
MicroRNAs (miRNAs) are small non-coding RNAs that are about 22 nucleotides in length. They regulate gene expression post-transcriptionally by guiding the effector protein Argonaute to its target mRNA in a sequence-dependent manner, causing the ...
Toyotaka Yoshida, Yoshimasa Asano, Kumiko Ui-Tei   +2 more
doaj   +1 more source

Link Prediction using Top-$k$ Shortest Distances

, 2017
In this paper, we apply an efficient top-$k$ shortest distance routing algorithm to the link prediction problem and test its efficacy. We compare the results with other base line and state-of-the-art methods as well as with the shortest path. Our results
Lebedev, Andrei, Lee, JooYoung, Mazzara, Manuel, Rivera, Victor   +3 more
core   +1 more source

Senescence in Normal Human Dermal Fibroblasts Induces Heterogeneous Fibril Orientation of Type I Collagen Through Downregulation of BMP‐1

Genes to Cells, Volume 31, Issue 2, March 2026.
Senescent fibroblasts construct collagen fibrils, whose orientation is disturbed. We found that senescent fibroblasts downregulate C‐pp cleavage enzymes BMP‐1 and PCPE‐1, which results in downregulation of C‐pp cleavage. This was demonstrated by conducting BMP‐1 knockdown experiments in young fibroblasts, which led to a disturbance in the orientation ...
Koji Moriya, Yuki Shibaike, Katsura Sano, Toshiaki Tanaka   +3 more
wiley   +1 more source

Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications. [PDF]

, 2015
Fibroblast growth factors (FGFs) and their receptors (FGFRs) are transmembrane growth factor receptors with wide tissue distribution. FGF/FGFR signaling is involved in neoplastic behavior and also development, differentiation, growth, and survival.
Helsten, Teresa, Kurzrock, Razelle, Schwaederle, Maria   +2 more
core   +2 more sources