The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin. [PDF]
PLoS ONE, 2012 The tumour suppressor Adenomatous Polyposis Coli (APC) is required for proper mitosis; however, the exact role of APC in mitosis is not understood. Using demembranated sperm chromatin exposed to meiotic Xenopus egg extract and HeLa cells expressing ...
Dina Dikovskaya +8 more
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Characterization of Adenomatous Polyposis Coli Protein Dynamics and Localization at the Centrosome. [PDF]
Cancers (Basel), 2016 The adenomatous polyposis coli (APC) tumor suppressor is a multifunctional regulator of Wnt signaling and acts as a mobile scaffold at different cellular sites.
Lui C, Mok MT, Henderson BR.
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The adenomatous polyposis coli protein 3o years on [PDF]
bioRxiv, 2022 Mutations in the gene encoding the Adenomatous polyposis coli protein (APC) were discovered as driver mutations in colorectal cancers almost 30 years ago.
James Abbott, Inke Näthke
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Bi-allelic Loss of Human APC2, Encoding Adenomatous Polyposis Coli Protein 2, Leads to Lissencephaly, Subcortical Heterotopia, and Global Developmental Delay. [PDF]
Am J Hum Genet, 2019 Lissencephaly is a severe brain malformation in which failure of neuronal migration results in agyria or pachygyria and in which the brain surface appears unusually smooth.
Lee S +23 more
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Membrane Localization of Adenomatous Polyposis Coli Protein at Cellular Protrusions [PDF]
Journal of Biological Chemistry, 2006 Adenomatous polyposis coli protein (APC) translocates to, and stabilizes, the plus-ends of microtubules. In microtubule-dependent cellular protrusions, APC frequently accumulates in peripheral clusters at the basal membrane.
Manisha Sharma +5 more
semanticscholar +4 more sources
PLoS ONE, 2020 This study was performed to determine the clinical significance of adenomatous polyposis coli (APC)-binding protein end-binding 1 (EB1) in hepatocellular carcinoma (HCC) and to characterize its biochemical role in comparison with previous reports.
Takeshi Aiyama +8 more
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Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1 [PDF]
Journal of Cell Biology, 2010 The microtubule regulator APC is now shown to also regulate actin filament dynamics through its C-terminal “Basic” domain.
Kyoko Okada +7 more
semanticscholar +4 more sources
Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein. [PDF]
PLoS ONE, 2011 The human Discs Large 1 (DLG1) protein uses two of its three PDZ domains to interact with the C-terminal peptide of the Adenomatous Polyposis Coli (APC) tumor suppressor protein.
Zhenyi Zhang +7 more
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Adenomatous Polyposis Coli Protein Deletion in Efferent Olivocochlear Neurons Perturbs Afferent Synaptic Maturation and Reduces the Dynamic Range of Hearing. [PDF]
J Neurosci, 2015 Hickman TT, Liberman MC, Jacob MH.
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NH2-terminal Deletion of β-Catenin Results in Stable Colocalization of Mutant β-Catenin with Adenomatous Polyposis Coli Protein and Altered MDCK Cell Adhesion [PDF]
Journal of Cell Biology, 1997 β-Catenin is essential for the function of cadherins, a family of Ca2+-dependent cell–cell adhesion molecules, by linking them to α-catenin and the actin cytoskeleton.
Angela I. M. Barth +4 more
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