Adenomatous Polyposis Coli Protein 2 [PDF]
Definitions, 2020 National Cancer Institute
semanticscholar +3 more sources
Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities. [PDF]
Mol Psychiatry, 2014 Intellectual disabilities (IDs) and autism spectrum disorders link to human APC inactivating gene mutations. However, little is known about adenomatous polyposis coli's (APC's) role in the mammalian brain. This study is the first direct test of the impact of APC loss on central synapses, cognition and behavior. Using our newly generated APC conditional
Mohn JL +7 more
europepmc +5 more sources
The adenomatous polyposis coli protein 30 years on.
Seminars in Cell & Developmental Biology, 2023 Mutations in the gene encoding the Adenomatous polyposis coli protein (APC) were discovered as driver mutations in colorectal cancers almost 30 years ago.
J. Abbott, I. Näthke
semanticscholar +4 more sources
Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein [PDF]
Proceedings of the National Academy of Sciences, 1997 Mutation of the adenomatous polyposis coli ( APC ) gene is an early step in the initiation of colon cancer. Because the distribution pattern of a protein within the cell can provide important clues as to function, we have used a combination of immunofluorescence microscopy and biochemical fractionation to determine ...
Kristi L. Neufeld, R. White
semanticscholar +5 more sources
Mitochondrial Targeting of Adenomatous Polyposis Coli Protein Is Stimulated by Truncating Cancer Mutations [PDF]
Journal of Biological Chemistry, 2007 The adenomatous polyposis coli (APC) protein tumor suppressor is mutated in the majority of colon cancers. Most APC gene mutations cause deletion of the C terminus and disrupt APC regulation of β-catenin turnover, microtubule dynamics, and chromosome ...
Mariana Brocardo +5 more
semanticscholar +3 more sources
Cell Density and Phosphorylation Control the Subcellular Localization of Adenomatous Polyposis Coli Protein [PDF]
Molecular and Cellular Biology, 2001 Loss of functional adenomatous polyposis coli protein (APC) leads to uncontrolled proliferation of colonic epithelial cells, as evidenced by polyp formation, a prelude to carcinogenesis. As a tumor suppressor, APC targets the oncogene beta-catenin for proteasome-mediated cytoplasmic degradation.
Fang Zhang, R. White, Kristi L. Neufeld
semanticscholar +4 more sources
Deciphering the Causative Role of a Novel APC Gene Variant in Attenuated Familial Adenomatous Polyposis Using Germline DNA-RNA Paired Testing [PDF]
BiomedicinesBackground/Objectives: Familial adenomatous polyposis (FAP) is an autosomal dominant disorder caused by pathogenic variants in the adenomatous polyposis coli (APC) gene.
Giovanna Forte +11 more
doaj +2 more sources
Regulated Binding of Adenomatous Polyposis Coli Protein to Actin* [PDF]
Journal of Biological Chemistry, 2007 Adenomatous polyposis coli (APC) protein is a large tumor suppressor that is truncated in most colorectal cancers. The carboxyl-terminal third of APC protein mediates direct interactions with microtubules and the microtubule plus-end tracking protein EB1.
J. Moseley +5 more
semanticscholar +3 more sources
Circular RNA hsa_circ_0005114-miR-142-3p/miR-590-5p-adenomatous polyposis coli protein axis as a potential target for treatment of glioma. [PDF]
Oncol Lett, 2021 Wei B, Wang L, Zhao J.
europepmc +3 more sources
Pigmented Sorghum Phenolic Extracts Regulate the Expression of Cancer Development Pathway Genes in HT-29 and Hypoxia-Induced CCD 841 CoN Cells. [PDF]
Food Sci NutrA depiction of reconstituted red sorghum and black sorghum extract effects on HT‐29 and CCD 841 CoN cell cells at 500 and 2000 μg/mL for 12 and 24 h resulting in the decrease of cancer cell viability, modulation of mutation‐associated genes, and suppression of hypoxia and metabolic signaling.
Collins A +4 more
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