Results 201 to 210 of about 23,918 (237)

Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress.

The International Journal of Biochemistry & Cell Biology, 2011
The adenomatous polyposis coli (APC) tumor suppressor traffics between nucleus and cytoplasm to perform distinct functions. Here we identify a specific role for APC in the DNA replication stress response. The silencing of APC caused an accumulation of asynchronous cells in early S phase and delayed S phase progression in cells released from hydroxyurea-
M. Brocardo, J. Borowiec, B. Henderson
semanticscholar   +3 more sources

Adenomatous polyposis coli proteins and cell adhesion

Current Opinion in Cell Biology, 2004
Adenomatous polyposis coli (APC) is an important tumour suppressor in the mammalian intestinal epithelium. It binds to beta-catenin and its role as a tumour suppressor depends predominantly on its ability to downregulate soluble beta-catenin, a key effector of the Wnt signalling pathway.
Mariann, Bienz, Fumihiko, Hamada
openaire   +2 more sources

Adenomatous polyposis coli, protein kinases, protein tyrosine phosphatase: The effect of sulindac

Journal of Surgical Oncology, 1995
AbstractA putative explanation of the effect of sulindac on adenomatous colon and duodenal polyps from clinical observations and related in vitro experiments is presented. In cells with mutant APC genes, persistent high prostaglandin content of polyps leads to desensitization, downregulation of adenylate cyclase, uncoupling of cAMP synthesis from ...
W R, Waddell, R L, Miesfeld
openaire   +2 more sources

The adenomatous polyposis coli tumor suppressor protein and microtubule dynamics

Current Colorectal Cancer Reports, 2007
Colorectal cancer is closely associated with mutation of the gene encoding the adenomatous polyposis coli (APC) tumor suppressor protein. A role has been defined for APC in the Wnt signaling pathway, in which it is responsible for mediating the degradation of the protein β-catenin.
Anke Brüning-Richardson, Ewan E. Morrison   +1 more
openaire   +1 more source

Truncated adenomatous polyposis coli (APC) tumour suppressor protein can undergo tyrosine phosphorylation

European Journal of Cancer, 2000
Numerous mutations in the adenomatous polyposis coli (APC) gene have been described in colorectal cancer. The vast majority introduce nonsense codons leading to the production of truncated N-terminal APC fragments. Mutations occurring before APC codon 158, have been associated with an attenuated form of familial adenomatous polyposis whereas those ...
A L, Norris, P M, Clissold, J M, Askham, E E, Morrison, P, Moncur, S H, McCall, P L, Coletta, D M, Meredith, A F, Markham   +8 more
openaire   +2 more sources

Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein

Gene, 2005
The Adenomatous Polyposis Coli (APC) tumor suppressor is a multifunctional protein that is mutated in a majority of colon cancers. The role of APC as an antagonist of the Wnt signaling pathway is well known and it is widely accepted that inappropriate activation of this pathway through loss of APC function contributes to the progression of colon ...
Caroline A, Hanson, Jeffrey R, Miller
openaire   +2 more sources

Adenomatous Polyposis Coli (APC) Protein Expression in Primary and Metastatic Serous Ovarian Carcinoma

International Journal of Surgical Pathology, 2002
The aim of this study was to investigate protein expression of adenomatous polypois coli (APC) in primary and metastatic serous ovarian carcinoma. The expression of 3-catenin and E-cadherin was additionally analyzed. One hundred and thirteen priary (n=56) and metastatic (n=57) lesions were immunohistochemically stained for APC, E-cadherin, and f ...
Eleonora, Karbova, Ben, Davidson, Krassimir, Metodiev, Claes G, Tropé, Jahn M, Nesland   +4 more
openaire   +2 more sources

Phosphorylation of the adenomatous polyposis coli protein and its possible regulatory effects in cells.

Biochemical and Biophysical Research Communications, 1995
The adenomatous polyposis coli (APC) gene is etiologically associated with familial adenomatous polyposis and gastrointestinal malignancies, but its cellular function and role in tumorigenesis are unclear. Recent reports indicate that wild-type, but not mutant, APC gene product (APC) is associated with and promotes the assembly of cytoskeletal ...
G. Bhattacharya, B. Boman
semanticscholar   +3 more sources

Aspirin augments the expression of Adenomatous Polyposis Coli protein by suppression of IKKβ

Biochemical and Biophysical Research Communications, 2014
Aspirin has been widely used as analgesic, antipyretic and anti-inflammatory medicine for long. In addition to these traditional effects, clinical studies suggest that aspirin can protect against cancer, but its mechanism has not been explored. To unveil it, we identified the proteins up- or down-regulated after incubation with aspirin by using ...
Noboru, Ashida, Masako, Kishihata, Dat Nguyen, Tien, Kaeko, Kamei, Takeshi, Kimura, Masayuki, Yokode   +5 more
openaire   +2 more sources

Regulated nuclear import of the adenomatous polyposis coli protein.

2012
Mutation of the Adenomatous Polyposis Coli (APC) gene is an early step in the development of colorectal carcinomas. To provide clues for APC's role in tumor suppression, the subcellular distribution of APC was studied, and APC was found to localize to both the cytoplasm and the nucleus of normal human epithelial cells. The objectives of this study were
openaire   +1 more source