Results 31 to 40 of about 23,918 (237)

AXIN2-Associated Adenomatous Colorectal Polyposis

Journal of Coloproctology, 2021
Introduction Most cases of colorectal cancer (CRC) occur sporadically; however, ∼ 3% to 6% of all CRCs are related to inherited syndromes, such as Lynch syndrome and familial adenomatous polyposis (FAP).
Bruno Augusto Alves Martins, Reinaldo Falluh Filho, Romulo Medeiros de Almeida, Renata Lazari Sandoval   +3 more
doaj   +1 more source

Rational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors

Nature Communications, 2022
The adenomatous polyposis coli (APC)–Asef protein interaction is essential for colorectal cancer metastasis. Here, the authors present the rational design of a sensitivity-enhanced tracer for fluorescence polarization assays, enabling them to discover ...
Jie Zhong, Yuegui Guo, Shaoyong Lu, Kun Song, Ying Wang, Li Feng, Zhen Zheng, Qiufen Zhang, Jiacheng Wei, Peng Sang, Yan Shi, Jianfeng Cai, Guoqiang Chen, Chen-Ying Liu, Xiuyan Yang, Jian Zhang   +15 more
doaj   +1 more source

Identification of a novel CNV at the APC gene in a Chinese family with familial adenomatous polyposis

Frontiers in Molecular Biosciences, 2023
Introduction: Familial adenomatous polyposis (FAP) is the second most commonly inherited colorectal cancer (CRC) predisposition caused by germline mutations within the adenomatous polyposis coli (APC) gene.
Juyi Li, Chengzhi He, Jing Gong, Xiufang Wang, Chao Liu, Aiping Deng, Lin Zhu   +6 more
doaj   +1 more source

Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein. [PDF]

Proceedings of the National Academy of Sciences, 2000
Mutation of the adenomatous polyposis coli ( APC ) gene is an early step in the development of colorectal carcinomas. APC protein is located in both the cytoplasm and the nucleus. The objective of this study was to define the nuclear localization signals (NLSs) in APC protein.
Fang Zhang, Ray White, Kristi L. Neufeld
semanticscholar   +3 more sources

Immunopurification of adenomatous polyposis coli (APC) proteins [PDF]

BMC Research Notes, 2013
AbstractBackgroundTheadenomatous polyposis coli(APC) tumour suppressor gene encodes a 2843 residue (310 kDa) protein. APC is a multifunctional protein involved in the regulation of β-catenin/Wnt signalling, cytoskeletal dynamics and cell adhesion.APCmutations occur in most colorectal cancers and typically result in truncation of the C-terminal half of ...
Elliott, KL, Catimel, B, Church, NL, Coates, JL, Burgess, AW, Layton, MJ, Faux, MC   +6 more
openaire   +3 more sources

Mutational Analysis of a Familial Adenomatous Polyposis Pedigree with Bile Duct Polyp Phenotype

Canadian Journal of Gastroenterology and Hepatology, 2021
A large number of colorectal cancers have a genetic background in China. However, due to insufficient awareness, the diagnostic rate remains low and merely 5-6% of colorectal cancer patients are diagnosed with hereditary colorectal cancer.
Li-jun Xie, Dan-dan Ruan, Jian-hui Zhang, Yi Li, Li Chen, Mao-lin Yan, Ming-dian Yu, Jie-wei Luo, Hui-zhen Zhang   +8 more
doaj   +1 more source

Statin Treatment as a Targeted Therapy for APC-Mutated Colorectal Cancer

Frontiers in Oncology, 2022
BackgroundMutations in the tumor suppressor gene Adenomatous Polyposis Coli (APC) are found in 80% of sporadic colorectal cancer (CRC) tumors and are also responsible for the inherited form of CRC, Familial adenomatous polyposis (FAP).MethodsTo identify ...
Hannah Shailes, Wai Yiu Tse, Marta O. Freitas, Andrew Silver, Sarah A. Martin   +4 more
doaj   +1 more source

Neuronal Nicotinic Synapse Assembly Requires the Adenomatous Polyposis Coli Tumor Suppressor Protein [PDF]

The Journal of Neuroscience, 2004
Normal cognitive and autonomic functions require nicotinic synaptic signaling. Despite the physiological importance of these synapses, little is known about molecular mechanisms that direct their assembly during development. We show here that the tumor-suppressor protein adenomatous polyposis coli (APC) functions in localizing α3 ...
Murali K. Temburni, Madelaine M. Rosenberg, Narendra Pathak, Russell E. McConnell, Michele H. Jacob   +4 more
openalex   +4 more sources

The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis. [PDF]

Cancer Research, 2005
Abstract The adenomatous polyposis coli (APC) gene, whose mutations are responsible for familial adenomatous polyposis, is a major negative controller of the Wnt/β-catenin pathway. To investigate the dose-dependent effects of APC protein in suppressing intestinal tumorigenesis, we constructed mutant mice carrying hypomorphic Apc alleles ...
Qin Li, T. Ishikawa, M. Oshima, M. Taketo   +3 more
semanticscholar   +3 more sources

Adenomatous polyposis coli protein (APC)-independent regulation of β-catenin/Tcf-4 mediated transcription in intestinal cells [PDF]

Biochemical Journal, 1999
Josep Baulida, Eduard Batlle, Antonio Garcı́a de Herreros   +2 more
openalex   +2 more sources