Results 41 to 50 of about 23,918 (237)

Adenomatous Polyposis Coli Associates with the Microtubule-Destabilizing Protein XMCAK [PDF]

Current Biology, 2004
During cell division, the proper formation of a bipolar spindle and its function to segregate chromosomes requires precise coordination of microtubule-stabilizing and destabilizing activities. Globally destabilized, dynamic microtubules radiating from duplicated centrosomes are locally regulated by chromosomes.
Banks, Jennifer D., Heald, Rebecca
openaire   +2 more sources

An APC Mutation in a Large Chinese Kindred With Familial Adenomatous Polyposis Was Identified Using Both Next Generation Sequencing and Simple STR Marker Haplotypes

Frontiers in Genetics, 2020
BackgroundFamilial adenomatous polyposis (FAP) is an autosomal dominant disorder characterized primarily by the development of numerous adenomatous polyps in the colon and a high risk for colorectal cancer.
Qitao Zhan, Liya Wang, Xiangrong Xu, Yan Sun, Lejun Li, Xuchen Qi, Feng Chen, Xiaoming Wei, Michael L. Raff, Ping Yu, Fan Jin   +10 more
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T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations

Frontiers in Immunology, 2023
Familial adenomatous polyposis (FAP) is an inherited disease characterized by the development of large number of colorectal adenomas with high risk of evolving into colorectal tumors. Mutations of the Adenomatous polyposis coli (APC) gene is often at the
Céline Cuche, Marta Mastrogiovanni, Marta Mastrogiovanni, Marie Juzans, Marie Juzans, Hélène Laude, Marie-Noëlle Ungeheuer, Daniel Krentzel, Maria Isabella Gariboldi, Daniel Scott-Algara, Marianne Madec, Sophie Goyard, Sophie Goyard, Camille Floch, Camille Floch, Gaëlle Chauveau-Le Friec, Pierre Lafaye, Charlotte Renaudat, Muriel Le Bidan, Christine Micallef, Sandrine Schmutz, Sébastien Mella, Sébastien Mella, Sophie Novault, Milena Hasan, Darragh Duffy, Vincenzo Di Bartolo, Andrés Alcover   +27 more
doaj   +1 more source

Adenomatous Polyposis Coli (APC) in cell migration

European Journal of Cell Biology, 2022
Adenomatous Polyposis Coli (APC) protein is mostly known as a tumor suppressor that regulates Wnt signaling, but is also an important cytoskeletal protein.
Xingyuan Fang, Tatyana M. Svitkina
doaj   +1 more source

Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth

eLife, 2023
ZRANB1 (human Trabid) missense mutations have been identified in children diagnosed with a range of congenital disorders including reduced brain size, but how Trabid regulates neurodevelopment is not understood.
Daniel Frank, Maria Bergamasco, Michael J Mlodzianoski, Andrew Kueh, Ellen Tsui, Cathrine Hall, Georgios Kastrappis, Anne Kathrin Voss, Catriona McLean, Maree Faux, Kelly L Rogers, Bang Tran, Elizabeth Vincan, David Komander, Grant Dewson, Hoanh Tran   +15 more
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Lack of Adenomatous Polyposis Coli Protein Correlates with a Decrease in Cell Migration and Overall Changes in Microtubule Stability

Molecular Biology of the Cell, 2006
Karin Kroboth, Ian P. Newton, Katsuhiro Kita, Dina Dikovskaya, Jürg Zumbrunn, Clare M. Waterman, Inke Näthke   +6 more
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Adenomatous Polyposis Coli as a Scaffold for Microtubule End-Binding Proteins

Journal of Molecular Biology, 2019
End-binding proteins (EBs), referred to as the core components of the microtubule plus-end tracking protein network, interact with the C-terminus of the adenomatous polyposis coli (APC) tumor suppressor. This interaction is disrupted in colon cancers expressing truncated APC.
Laurence Serre, Virginie Stoppin‐Mellet, Isabelle Arnal   +2 more
openalex   +6 more sources

Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein [PDF]

Proceedings of the National Academy of Sciences, 2002
Mutations in the adenomatous polyposis coli ( APC ) gene are responsible for familial adenomatous polyposis coli and also sporadic colorectal cancer development. By using antibodies raised against the N-terminal region of APC protein, we have detected the variable masses of endogenous APC proteins in individual cell
M. Homma, Dongxia Li, E. Krebs, Y. Yuasa, Y. Homma   +4 more
semanticscholar   +3 more sources

A pan-cancer analysis on the carcinogenic effect of human adenomatous polyposis coli.

PLoS ONE, 2022
Adenomatous polyposis coli (APC) is the most commonly mutated gene in colon cancer and can cause familial adenomatous polyposis (FAP). Hypermethylation of the APC promoter can also promote the development of breast cancer, indicating that APC is not ...
Yinci Zhang, Xinkuang Liu, Amin Li, Xiaolong Tang   +3 more
doaj   +2 more sources

Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy

Frontiers in Molecular Biosciences, 2021
In Colorectal cancer (CRC), adenomatous polyposis coli (APC) directly interacts with the Rho guanine nucleotide exchange factor 4 (Asef) and releases its GEF activity.
Xiuyan Yang, Jie Zhong, Qiufen Zhang, Li Feng, Zhen Zheng, Jian Zhang, Jian Zhang, Shaoyong Lu   +7 more
doaj   +1 more source