Results 51 to 60 of about 23,918 (237)

Addition of exogenous diacylglycerol enhances Wnt/β-catenin signaling through stimulation of macropinocytosis

iScience, 2023
Summary: Activation of Wnt signaling triggers macropinocytosis and drives many tumors. We now report that the exogenous addition of the second messenger lipid sn-1,2 DAG to the culture medium rapidly induces macropinocytosis.
Yagmur Azbazdar, Nydia Tejeda-Munoz, Julia C. Monka, Alex Dayrit, Grace Binder, Gunes Ozhan, Edward M. De Robertis   +6 more
doaj   +1 more source

A New Germline Stop Codon Mutation in Exon 15 of the Gene Predisposing to Familial Adenomatous Polyposis

The International Journal of Biological Markers, 2013
Familial adenomatous polyposis (FAP) is an autosomal dominant disorder related to germline mutations of the adenomatous polyposis coli ( APC ) gene. It is characterized by the detection of numerous adenomatous polyps that, if untreated, develop into ...
Laura Schirosi, Marcello Pellegrino, Paolo Tarantino, Salvatore Mauro, Andrea Tinelli, Marilena Greco PhD   +5 more
doaj   +1 more source

Neuronal localization of the adenomatous polyposis coli tumor suppressor protein

Neuroscience, 1999
Recent biochemical studies have demonstrated that the adenomatous polyposis coli gene, initially identified via its link to colon cancer, is expressed at high levels in the brain. Furthermore, the ability of this tumor suppressor protein to bind to Discs-Large and beta-catenin, proteins implicated in organizing synaptic structure, point to a role for ...
J S, Brakeman, S H, Gu, X B, Wang, G, Dolin, J M, Baraban   +4 more
openaire   +2 more sources

Rapamycin inhibition of polyposis and progression to dysplasia in a mouse model.

PLoS ONE, 2014
Familial adenomatous polyposis (FAP) is often due to adenomatous polyposis coli (APC) gene germline mutations. Somatic APC defects are found in about 80% of colorectal cancers (CRCs) and adenomas.
Karin M Hardiman, Jianhua Liu, Ying Feng, Joel K Greenson, Eric R Fearon   +4 more
doaj   +1 more source

Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations

Cell Reports, 2021
Summary: Colorectal cancer (CRC) is one of the most common cancers worldwide, in which adenomatous polyposis coli (APC) mutations are frequently and uniquely observed.
Zhenzhen Chen, Jiayi Wu, Benyu Liu, Guangtan Zhang, Zhiwei Wang, Lulu Zhang, Kaili Wang, Zusen Fan, Pingping Zhu   +8 more
doaj   +1 more source

Targeting Stem Cell Behavior in Desmoid Tumors (Aggressive Fibromatosis) by Inhibiting Hedgehog Signaling

Neoplasia: An International Journal for Oncology Research, 2013
Desmoid tumor (also called aggressive fibromatosis) is a lesion of mesenchymal origin that can occur as a sporadic tumor or a manifestation of the preneoplastic syndrome, familial adenomatous polyposis caused by a mutation in adenomatous polyposis coli ...
Ronak Ghanbari-Azarnier, Shingo Sato, Qingxia Wei, Mushriq Al-Jazrawe, Benjamin A. Alman   +4 more
doaj   +1 more source

RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells

Molecular Oncology, 2022
Ribosomal biogenesis and protein synthesis are deregulated in most cancers, suggesting that interfering with translation machinery may hold significant therapeutic potential. Here, we show that loss of the tumor suppressor adenomatous polyposis coli (APC)
Christoph Otto, Carolin Kastner, Stefanie Schmidt, Konstantin Uttinger, Apoorva Baluapuri, Sarah Denk, Mathias T. Rosenfeldt, Andreas Rosenwald, Florian Roehrig, Carsten P. Ade, Christina Schuelein‐Voelk, Markus E. Diefenbacher, Christoph‐Thomas Germer, Elmar Wolf, Martin Eilers, Armin Wiegering   +15 more
doaj   +1 more source

APC-driven actin nucleation powers collective cell dynamics in colorectal cancer cells

iScience, 2023
Summary: Cell remodeling relies on dynamic rearrangements of cell contacts powered by the actin cytoskeleton. The tumor suppressor adenomatous polyposis coli (APC) nucleate actin filaments (F-actin) and localizes at cell junctions.
Lautaro Baro, Asifa Islam, Hannah M. Brown, Zoë A. Bell, M. Angeles Juanes   +4 more
doaj   +1 more source

Small molecule-induced destabilization of β-catenin and RAS is the ideal strategies for suppressing colorectal cancer [PDF]

Organoid, 2023
Background Mutations of adenomatous polyposis coli (APC) and KRAS play essential roles in the development of colorectal cancer (CRC) by forming an abnormal colon morphology.
Yonghyo Kim, Myoung-Hee Kang, Geon-Woo Kim, Yong-Hee Cho   +3 more
doaj   +1 more source

Characterization of a 60S complex of the adenomatous polyposis coli tumor suppressor protein

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2006
The tumor suppressor protein adenomatous polyposis coli (APC) is a multifunctional protein with a well characterized role in the Wnt signal transduction pathway and roles in cytoskeletal regulation and cell polarity. The soluble pool of APC protein in colon epithelial tumor cells exists in two distinct complexes fractionating at approximately 20S and ...
Sreekala Mahadevaiyer, Chong Xu, Barry M. Gumbiner   +2 more
openalex   +3 more sources