Results 21 to 30 of about 489,446 (226)
Current Neuropharmacology, 2009 Over the last several decades the idea that adenosine (Ado) plays a role in sleep control was postulated due in large part to pharmacological studies that showed the ability of Ado agonists to induce sleep and Ado antagonists to decrease sleep. A second wave of research involving in vitro cellular analytic approaches and subsequently, the use of ...
Theresa E. Bjorness, Robert W. Greene
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Extracellular adenosine triphosphate and adenosine in cancer [PDF]
Oncogene, 2010 Adenosine triphosphate (ATP) is actively released in the extracellular environment in response to tissue damage and cellular stress. Through the activation of P2X and P2Y receptors, extracellular ATP enhances tissue repair, promotes the recruitment of immune phagocytes and dendritic cells, and acts as a co-activator of NLR family, pyrin domain ...
Stagg, J., Smyth, M. J.
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A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Nature Chemical Biology, 2013 N6-methyladenosine (m6A) is the most prevalent and reversible internal modification in mammalian messenger and non-coding RNAs. We report here that human METTL14 catalyzes m6A RNA methylation.
Jianzhao Liu +12 more
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The dynamics of single spike-evoked adenosine release in the cerebellum [PDF]
, 2010 The purine adenosine is a potent neuromodulator in the brain, with roles in a number of diverse physiological and pathological processes. Modulators such as adenosine are difficult to study as once released they have a diffuse action (which can affect ...
Beierlein +41 more
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PHOSPHORYLATION OF MONOACETONE ADENOSINE AND OF DIACETYL ADENOSINE
Journal of Biological Chemistry, 1937 P.A. Levene, R. Stuart Tipson
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Upregulation of inducible NO synthase by exogenous adenosine in vascular smooth muscle cells activated by inflammatory stimuli in experimental diabetes [PDF]
, 2016 BACKGROUND: Adenosine has been shown to induce nitric oxide (NO) production via inducible NO synthase (iNOS) activation in vascular smooth muscle cells (VSMCs). Although this is interpreted as a beneficial vasodilating pathway in vaso-occlusive disorders,
Cignarella, Andrea +4 more
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Pharmacology of Adenosine Receptors: The State of the Art.
Physiological Reviews, 2018 Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid generation of adenosine from cellular metabolism, and the widespread distribution
P. Borea +4 more
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Journal of Experimental Medicine, 2007 The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define mechanisms of suppression.
S. Deaglio +12 more
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Stimulation of endothelial adenosine Al receptors enhances adhesion of neutrophils in the intact guinea pig coronary system [PDF]
, 1994 Objective: The primary aim was to determine the action of pathophysiologically relevant adenosine concentrations (0.1-1 μM) on adhesion of neutrophils to coronary endothelium.
Becker, Bernhard F. +3 more
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Adenosine and adenosine antagonism in asthma [PDF]
Thorax, 1998 I read with interest the excellent update on adenosine by Polosa and Holgate.1 An important use of this challenge agent is demonstrated and adenosine antagonism as a potential treatment for asthma is revisited. However, the role of adenosine as a mediator of asthma is somewhat inconsistent with several functional observations.
C. PERSSON;, S. T HOLGATE
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