Results 21 to 30 of about 559,924 (346)
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Nature Chemical Biology, 2013 N6-methyladenosine (m6A) is the most prevalent and reversible internal modification in mammalian messenger and non-coding RNAs. We report here that human METTL14 catalyzes m6A RNA methylation.
Jianzhao Liu +12 more
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Extracellular adenosine triphosphate and adenosine in cancer [PDF]
Oncogene, 2010 Adenosine triphosphate (ATP) is actively released in the extracellular environment in response to tissue damage and cellular stress. Through the activation of P2X and P2Y receptors, extracellular ATP enhances tissue repair, promotes the recruitment of immune phagocytes and dendritic cells, and acts as a co-activator of NLR family, pyrin domain ...
Stagg, J., Smyth, M. J.
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Purines and Carotid Body: New Roles in Pathological Conditions
Frontiers in Pharmacology, 2017 It is known that adenosine and adenosine-5′-triphosphate (ATP) are excitatory mediators involved in carotid body (CB) hypoxic signaling. The CBs are peripheral chemoreceptors classically defined by O2, CO2, and pH sensors.
Silvia V. Conde +2 more
doaj +1 more source
Pharmacology of Adenosine Receptors: The State of the Art.
Physiological Reviews, 2018 Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid generation of adenosine from cellular metabolism, and the widespread distribution
P. Borea +4 more
semanticscholar +1 more source
Safety profile of adenosine stress cardiac MRI in a tertiary hospital in India
Indian Journal of Radiology and Imaging, 2020 Background: Coronary artery disease (CAD) is a major cause of morbidity and mortality in India. Stress Cardiac Magnetic Resonance (CMR) using vasodilator agent is well established in assessing the functional significance of CAD.
Vimal Raj +4 more
doaj +1 more source
Journal of Experimental Medicine, 2007 The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define mechanisms of suppression.
S. Deaglio +12 more
semanticscholar +1 more source
Adenosine and adenosine antagonism in asthma [PDF]
Thorax, 1998 I read with interest the excellent update on adenosine by Polosa and Holgate.1 An important use of this challenge agent is demonstrated and adenosine antagonism as a potential treatment for asthma is revisited. However, the role of adenosine as a mediator of asthma is somewhat inconsistent with several functional observations.
C. PERSSON;, S. T HOLGATE
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Adenosine and preeclampsia [PDF]
Molecular Aspects of Medicine, 2017 Adenosine is an endogenous nucleoside with pleiotropic effects in different physiological processes including circulation, renal blood flow, immune function, or glucose homeostasis. Changes in adenosine membrane transporters, adenosine receptors, and corresponding intracellular signalling network associate with development of pathologies of pregnancy ...
Fabián Pardo +12 more
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Crystal structure of 8-(4-methylphenyl)-2′-deoxyadenosine hemihydrate
Acta Crystallographica Section E: Crystallographic Communications, 2018 In the asymmetric unit, equalling the unit cell (triclinic, P1, Z = 1), two molecules of the title compound, 8-(4-methylphenyl)-d-2′-deoxyadenosine, C17H19N5O3, are present, with distinct conformations of the two sugar moieties, together with one solvent
Ajaykumar V. Ardhapure +4 more
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Frontiers in Cardiovascular Medicine, 2021 Background: Ischemia with non-obstructive coronary arteries (INOCA) is part of the ischemic heart disease spectrum, and is particularly observed in women.
Caitlin E. M. Vink +4 more
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