Results 21 to 30 of about 617,017 (357)
Journal of Experimental Medicine, 2007 The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define mechanisms of suppression.
S. Deaglio +12 more
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Pharmacology of Adenosine Receptors: The State of the Art.
Physiological Reviews, 2018 Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid generation of adenosine from cellular metabolism, and the widespread distribution
P. Borea +4 more
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Nanomaterials, 2021 Carbon nanotube field effect transistor (CNT FET) aptasensors have been investigated for the detection of adenosine using two different aptamer sequences, a 35-mer and a 27-mer.
Hong Phan T. Nguyen +2 more
doaj +1 more source
Squalene-Adenosine Nanoparticles: Ligands of Adenosine Receptors or Adenosine Prodrug? [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2019 Adenosine receptors (ARs) represent key drug targets in many human pathologies, including cardiovascular, neurologic, and inflammatory diseases. To overcome the very rapid metabolization of adenosine, metabolically stable AR agonists and antagonists were developed.
Rouquette, Marie +9 more
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Targeting adenosine for cancer immunotherapy
Journal of Immunotherapy for Cancer, 2018 Immune checkpoint antagonists (CTLA-4 and PD-1/PD-L1) and CAR T-cell therapies generate unparalleled durable responses in several cancers and have firmly established immunotherapy as a new pillar of cancer therapy.
R. Leone, L. Emens
semanticscholar +1 more source
Computerized Modeling of Adenosine Triphosphate, Adenosine Triarsenate and Adenosine Trivanadate [PDF]
Molecules, 2012 Computerized molecular models of adenosine triphosphate, adenosine tri-arsenate and adenosine trivanadate have been generated using the molecular mechanics technique. The analysis of structural parameters indicated that, at least theoretically, adenosine triarsenate is a realistic candidate for replacement of adenosine triphosphate in biochemical ...
Nascimento, Valter A. +2 more
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The Effect of Low-Doses of Caffeine and Taurine on Convulsive Seizure Parameters in Rats
Behavioral Sciences, 2020 Introduction: Caffeine, an adenosine-receptor blocker, is believed to have neuronal excitatory effects, while Taurine, a mammalian amino acid, was shown to have neuroinhibitory effects.
Mohamed Jailani +9 more
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Journal of Alzheimer's Disease, 2010 Caffeine causes most of its biological effects via antagonizing all types of adenosine receptors (ARs): A1, A2A, A3, and A2B and, as does adenosine, exerts effects on neurons and glial cells of all brain areas. In consequence, caffeine, when acting as an AR antagonist, is doing the opposite of activation of adenosine receptors due to removal of ...
Ribeiro, Joaquim A., Sebastião, Ana M
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Frontiers in Cardiovascular Medicine, 2022 In Marfan syndrome (MFS), dilation, dissection, and rupture of the aorta occur. Inflammation can be involved in the pathogenicity of aortic defects and can thus be a therapeutic target for MFS.
Maria Carolina Guido +10 more
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Journal of Experimental Medicine, 1997 Apoptosis and necrosis are considered conceptually and morphologically distinct forms of cell death. Here, we report that demise of human T cells caused by two classic apoptotic triggers (staurosporin and CD95 stimulation) changed from apoptosis to ...
M. Leist +4 more
semanticscholar +1 more source