Results 21 to 30 of about 892,163 (354)
Expanding a fluorescent RNA alphabet: synthesis, photophysics and utility of isothiazole-derived purine nucleoside surrogates. [PDF]
, 2017 A series of emissive ribonucleoside purine mimics, all comprised of an isothiazolo[4,3-d]pyrimidine core, was prepared using a divergent pathway involving a key Thorpe-Ziegler cyclization.
Fin, Andrea +2 more
core +1 more source
A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]
, 2011 The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
core +1 more source
Pharmacology of Adenosine Receptors: The State of the Art.
Physiological Reviews, 2018 Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid generation of adenosine from cellular metabolism, and the widespread distribution
P. Borea +4 more
semanticscholar +1 more source
Stability of Diluted Adenosine Solutions in Polyolefin Infusion Bags [PDF]
, 2013 Background Intravenous or intracoronary adenosine is used in the cardiac catherization lab to achieve maximal coronary blood flow and determine fractional flow reserve.
Almagambetova, Elise +3 more
core +2 more sources
Journal of Experimental Medicine, 2007 The study of T regulatory cells (T reg cells) has been limited by the lack of specific surface markers and an inability to define mechanisms of suppression.
S. Deaglio +12 more
semanticscholar +1 more source
Biosensor measurement of purine release from cerebellar cultures and slices [PDF]
, 2010 We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Dale, Nicholas +2 more
core +3 more sources
Targeting adenosine for cancer immunotherapy
Journal of Immunotherapy for Cancer, 2018 Immune checkpoint antagonists (CTLA-4 and PD-1/PD-L1) and CAR T-cell therapies generate unparalleled durable responses in several cancers and have firmly established immunotherapy as a new pillar of cancer therapy.
R. Leone, L. Emens
semanticscholar +1 more source
Frontiers in Cardiovascular Medicine, 2022 In Marfan syndrome (MFS), dilation, dissection, and rupture of the aorta occur. Inflammation can be involved in the pathogenicity of aortic defects and can thus be a therapeutic target for MFS.
Maria Carolina Guido +10 more
doaj +1 more source
Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function
Frontiers in Immunology, 2019 T cells play a critical role in cancer control, but a range of potent immunosuppressive mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their activity.
S. Viganó +6 more
semanticscholar +1 more source
The dynamics of single spike-evoked adenosine release in the cerebellum [PDF]
, 2010 The purine adenosine is a potent neuromodulator in the brain, with roles in a number of diverse physiological and pathological processes. Modulators such as adenosine are difficult to study as once released they have a diffuse action (which can affect ...
Beierlein +41 more
core +2 more sources