Results 71 to 80 of about 68,176 (222)

The Role of Magnesium in Liver Cirrhosis

Portal Hypertension &Cirrhosis, EarlyView.
Magnesium is a vital mineral involved in over 300 enzymatic reactions, crucial for physiological functions. Its deficiency, common in liver cirrhosis patients, correlates with poor outcomes by affecting inflammation, oxidative stress, fibrosis, and immunity. This review explores magnesium's role in cirrhosis and its interaction with disease mechanisms.
Weiye Zeng, Xudan Wang, He Qi, Hongtao Tang, Xun Qi   +4 more
wiley   +1 more source

Insights Into the Conformational Dynamics of the Cytoplasmic Domain of Metal‐Sensing Sensor Histidine Kinase ZraS

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT ZraS is a metal sensor integral to ZraPSR, a two‐component signaling system found in enterobacters. It belongs to a family of bifunctional sensor histidine kinases (SHKs) and is speculated to sense zinc‐induced stress on the bacterial envelope.
Nilima Mahapatra, Pranjal Mahanta, Shubhant Pandey, Rudresh Acharya   +3 more
wiley   +1 more source

Frequency Facilitation at Mossy Fiber–CA3 Synapses of Freely Behaving Rats Contributes to the Induction of Persistent LTD via an Adenosine-A1 Receptor-Regulated Mechanism [PDF]

Frequency facilitation (FF), comprising a rapid and multiple-fold increase in the magnitude of evoked field potentials, is elicited by low-frequency stimulation (LFS) at mossy fiber–CA3 synapses.
Abbracchio, Bardakjian, Bear, Bear, Bischofberger, Calixto, Chen, Costenla, D. Manahan-Vaughan, Derrick, Derrick, Dobrunz, Dudek, Dunwiddie, Gilbert, Goussakov, H. Hagena, Harris, Henze, Henze, Huang, Izaki, Johnston, Jung, Kamiya, Kamiya, Kemp, Kesner, Klausnitzer, Lambert, Lante, Lee, Lemon, Malenka, Manahan-Vaughan, Manahan-Vaughan, Manahan-Vaughan, Martin, Mulkey, Mulkey, Nakao, Nicoll, Pugliese, Salin, Scharfman, Staubli, Straube, Thomson, Toth, Vianna, Wang, Yeckel, Zalutsky, Zucker   +53 more
core   +2 more sources

Near‐Infrared Fluorescent Single‐Walled Carbon Nanotubes for Biosensing

Small, EarlyView.
Near‐infrared fluorescent single‐walled carbon nanotubes (SWCNTs) stand out as versatile biosensors due to their spectral overlap with the biological transparency window, surface‐sensitive fluorescence emission, and chemical modularity. This review offers a concise guide to understanding the photophysics of SWCNTs, various functionalization strategies,
Srestha Basu, Gili Bisker
wiley   +1 more source

Adenosine A2A receptors: localization and function [PDF]

, 2015
Adenosine is an endogenous purine nucleoside present in all mammalian tissues, that originates from the breakdown of ATP. By binding to its four receptor subtypes (A1, A2A, A2B, and A3), adenosine regulates several important physiological functions at ...
A Brand, A Gharib, A Kalhan, A Montinaro, A Mori, A Nishi, A Pinna, A Santos-Rodrigues Dos, A Sato, A Tomaru, AA Link, AE King, AK Dixon, AM Mott, AM Sebastiao, AM Sebastiao, AS Awad, B Sperlagh, B Sperlagh, B Sperlagh, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BD Hettinger, C Hammarberg, C Ledent, C Quiroz, C Salgado Garcia, CD Bonan, CM Anderson, CN Wilson, CP Sevigny, D Boison, D Boison, D Boison, D Joel, DC Cassada, DJ Brooks, DJ LaPar, DK Glover, DL Rosin, DL Rosin, DN Bowser, E Dare, E Mazzon, F Ciruela, F Ciruela, F Squadrito, FE Parkinson, G Burnstock, G Burnstock, G Burnstock, G Ghimire, G Haskó, G Schulte, G Schulte, GA Higgins, GE Garcia, GG Yegutkin, GM Halliday, GW Sullivan, H Kobayashi, H Zimmermann, HJ Groenewegen, I Feoktistov, J Espinosa, J Fastbom, J Kang, J Snel, J Tchekalarova, JA Ribeiro, JF Chen, JF Chen, JG Dobson Jr, JM Dickenson, JP Headrick, JR Fozard, JS Fink, K Biber, K Fuxe, K Yamada, KD Pierce, L Antonioli, L Antonioli, L Antonioli, L Belardinelli, L Wells, LC Rump, LP Shearman, M Canals, M Fornai, M Katebi, M Kawamura Jr, M Kurokawa, M Kurokawa, M Lazarus, M Matos, M Matos, M Milanese, M Morelli, M Morelli, M Odashima, M O’Neill, M Pouliot, M Reddington, M Schindler, M Storr, MA Ruiz, MA Schwarzschild, MA Souza, MA Trevethick, MC Wittendorp, MD Desrosiers, MD Okusa, MF Jarvis, MJ Bours, MJ Hussey, MJ Wall, MP Abbracchio, MP Abbracchio, MS Hershfield, N Ates, N Cabello, N Levens, N Rebola, N Rebola, N Simola, O Bonneau, O Cauli, O Pascual, P Carriba, P Carriba, P Popoli, P Popoli, P Svenningsson, P Svenningsson, P Svenningsson, P Svenningsson, P Voorn, PA LeWitt, PJ Gebicke-Haerter, R Rahimian, RA Cunha, RA Cunha, RA Cunha, RD Prediger, RH Al-Mashhadi, RJ Rodrigues, S Ferre, S Ferré, S Ferré, S Ferré, S Ferré, S James, S Latini, S Latini, S Revan, SA Baldwin, SA Hunsucker, SA Rivkees, SA Rivkees, SG Khasar, SJ Augood, SJ Brown, SM Duffy, SN Schiffmann, SN Schiffmann, SP Alexander, SW Schoen, T Eckle, T Kadowaki Horita, T Ochiishi, T Othman, TC Bingham, TF Wang, TH Adair, TV Dunwiddie, TV Dunwiddie, V Ralevic, W Hauber, Y Mizuno, Y Pankratov, Y Pankratov, Y Zhong, Z Díaz-Cabiale, Z Justinova, Z Kovacs, Z Selmeczy   +190 more
core   +1 more source

Characterisation of the adenosine A1 receptor in Saccharomyces cerevisiae

The FASEB Journal, 2008
Different ligands for G protein‐coupled receptors can induce unique receptor conformations, leading to differing profiles of G protein coupling. Given that S. cerevisiae expression systems are useful tools for studying the coupling of GPCRs to individual G protein pathways, experiments were undertaken to investigate whether different pharmacological ...
Greg Stewart, Simon J. Dowell, Arthur Christopoulos, Patrick M. Sexton, Peter J. Scammells   +4 more
openaire   +2 more sources

Semaglutide to remodel mitochondrial dynamics and mitophagy balance for vascular dementia therapy

VIEW, EarlyView.
The effects of semaglutide on IR, mitochondrial dynamics, and mitophagy in the hippocampus of BCAS mice after CCH. It was shown that semaglutide maintained the balance of mitochondrial dynamics and mitophagy by improving IR and passing through GLP‐1R/PI3K/Akt pathway, reduced hippocampal neuroinflammation and neuron loss, and thus promoted the recovery
Xiaoyan Yang, Peng Feng, Hongxu Zhu, Mingkang Wang, Nan Li, Bo Bai, Yuxiang Sun, Zhongrui Yan, Wenshi Wei, Jie Chang, Christian Hölscher, Wenxian Du   +11 more
wiley   +1 more source

Adenosine A2A Receptor Binding Profile of Two Antagonists, ST1535 and KW6002: Consideration on the Presence of Atypical Adenosine A2A Binding Sites [PDF]

, 2010
Adenosine A2A receptors seem to exist in typical (more in striatum) and atypical (more in hippocampus and cortex) subtypes. In the present study, we investigated the affinity of two adenosine A2A receptor antagonists, ST1535 [2 butyl -9-methyl-8-(2H-1,2 ...
Borsini, Franco, Leonardi, Fabiana, Riccioni, Teresa   +2 more
core   +3 more sources

Anxiolytic properties of A1 adenosine receptor PAMs

Oncotarget, 2016
Anxiolytic properties of A1 adenosine receptor ...
VINCENZI, Fabrizio, BOREA, Pier Andrea, VARANI, Katia   +2 more
openaire   +4 more sources

Nuclear respiratory factor‐1 (NRF1) induction as a powerful strategy to deter mitochondrial dysfunction and senescence in mesenchymal stem cells

Aging Cell, Volume 24, Issue 4, April 2025.
Mitochondrial dysfunction is associated with senescence, the latter proving detrimental to mesenchymal stem cell (MSC)‐based strategies. We induced the expression of nuclear respiratory factor‐1 (NRF1), a driver of mitochondrial biogenesis, to metabolically potentiate MSCs and stave off senescence.
Hyunho Lee, Matteo Massaro, Nourhan Abdelfattah, Gherardo Baudo, Haoran Liu, Kyuson Yun, Elvin Blanco   +6 more
wiley   +1 more source