Results 11 to 20 of about 24,787 (206)

Expression of poly(Adenosine Diphosphate-Ribose) polymerase protein in breast cancer [PDF]

Journal of Mid-Life Health, 2022
Background: The use of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors for breast cancer (BC) therapy is the subject of debate, and there is an urgent need to understand much the expression and prognostic role of the PARP1 protein.
Akanksha, Shashi Prakash Mishra, Amrita Ghosh Kar, J S Karthik, Aviral Srivastava, Rahul Khanna, Ram Niwas Meena   +6 more
doaj   +2 more sources

4-Thioribose Analogues of Adenosine Diphosphate Ribose (ADPr) Peptides. [PDF]

Org Lett, 2023
Adenosine diphosphate (ADP) ribosylation is an important post-translational modification (PTM) that plays a role in a wide variety of cellular processes. To study the enzymes responsible for the establishment, recognition, and removal of this PTM, stable analogues are invaluable tools.
Madern JM, Voorneveld J, Rack JGM, Kistemaker HAV, Ahel I, van der Marel GA, Codée JDC, Filippov DV.   +7 more
europepmc   +5 more sources

Roles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca(2+) signaling pathway. [PDF]

World J Biol Chem, 2014
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Wei W, Graeff R, Yue J.
europepmc   +3 more sources

Poly Adenosine Diphosphate-Ribose Polymerase (PARP) Inhibitors in Pancreatic Cancer. [PDF]

Cureus, 2022
Pancreatic cancer is the third most common cause of cancer death in the United States and eleventh worldwide. The majority of patients present with advanced disease with five-year overall survival of less than 10%. Traditional chemotherapy has been the mainstay treatment for years, with limited improvement in survival.
Sunkara T, Bandaru SS, Boyilla R, Kunadharaju R, Kukkadapu P, Chennamadhavuni A.   +5 more
europepmc   +4 more sources

Blocking Cyclic Adenosine Diphosphate Ribose-mediated Calcium Overload Attenuates Sepsis-induced Acute Lung Injury in Rats [PDF]

Chinese Medical Journal, 2016
Background: Acute lung injury (ALI) is a common complication of sepsis that is associated with high mortality. Intracellular Ca2+ overload plays an important role in the pathophysiology of sepsis-induced ALI, and cyclic adenosine diphosphate ribose ...
Qian-Yi Peng, Yu Zou, Li-Na Zhang, Mei-Lin Ai, Wei Liu, Yu-Hang Ai   +5 more
doaj   +2 more sources

Prognostic and clinicopathological value of poly (adenosine diphosphate-ribose) polymerase expression in breast cancer: A meta-analysis. [PDF]

PLoS ONE, 2017
BACKGROUND:Previous studies have shown that the poly (adenosine diphosphate-ribose) polymerase (PARP) level is a promising indicator of breast cancer. However, its prognostic value remains controversial. The present meta-analysis evaluated the prognostic
Weiqiang Qiao, Linlin Pan, Changgui Kou, Ke Li, Ming Yang   +4 more
doaj   +2 more sources

Poly(Adenosine diphosphate-ribose) polymerase inhibitors in cancer treatment. [PDF]

Hematol Oncol Clin North Am, 2012
Recently, the development of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors as a synthetic lethality approach has brought a major breakthrough in the treatment of breast cancer susceptibility gene (BRCA)-mutant cancers. Because sporadic cancers have also been found to commonly have other defects in DNA repair, PARP inhibitors are under
Park SR, Chen A.
europepmc   +4 more sources

A pan-tumor review of the role of poly(adenosine diphosphate ribose) polymerase inhibitors. [PDF]

CA Cancer J Clin
Hage Chehade C, Gebrael G, Sayegh N, Ozay ZI, Narang A, Crispino T, Golan T, Litton JK, Swami U, Moore KN, Agarwal N.   +10 more
europepmc   +2 more sources

O6-[(2″,3″-O-Isopropylidene-5″-O-^tbutyldimethylsilyl)pentyl]-5′-O-^tbutyldiphenylsilyl-2′,3′-O-isopropylideneinosine

Molbank, 2022
Cyclic adenosine diphosphate ribose (cADPR) is a cyclic nucleotide involved in the Ca2+ homeostasis. In its structure, the northern ribose, bonded to adenosine through an N1 glycosidic bond, is connected to the southern ribose through a pyrophosphate ...
Maria Marzano, Monica Terracciano, Vincenzo Piccialli, Ahmed Mahal, Roberto Nilo, Stefano D’Errico   +5 more
doaj   +1 more source

Multidisciplinary Care of a Large Brain Metastasis in a Patient with Hormone-Receptor-Positive Breast Cancer with Ataxia-Telangiectasia Mutation [PDF]

Journal of Immunotherapy and Precision Oncology, 2023
Poly (adenosine diphosphate-ribose) polymerase inhibitors (PARP)i are emerging as standard oncology treatments in various tumor types. The indications will expand as PARPi are being investigated in various breast cancer subtypes.
Anca Chelariu-Raicu, Sarina A. Piha-Paul, Mariana Chavez-MacGregor, Jason Johnson, Raymond Sawaya, Mary Frances McAleer, Alissa Nguyen, Audrey Hartnett, Apostolia M. Tsimberidou, Funda Meric-Bernstam, Ecaterina E. Dumbrava   +10 more
doaj   +1 more source