Results 21 to 30 of about 25,770 (257)

Model for Predicting Serious Hematological Adverse Events in Individuals With Ovarian Cancer Receiving Poly (Adenosine Diphosphate Ribose) Polymerase Inhibitor Treatment: Prospective Cohort Study.

JMIR Med Inform
Lian X, Lei Y.
europepmc   +2 more sources

Studies on the Polymer of Adenosine Diphosphate Ribose

Journal of Biological Chemistry, 1967
Yasutomi Nishizuka, Kunihiro Ueda, Kinya Nakazawa, Osamu Hayaishi   +3 more
  +5 more sources

Structure/function analysis of PARP-1 in oxidative and nitrosative stress-induced monomeric ADPR formation. [PDF]

PLoS ONE, 2009
Poly adenosine diphosphate-ribose polymerase-1 (PARP-1) is a multifunctional enzyme that is involved in two major cellular responses to oxidative and nitrosative (O/N) stress: detection and response to DNA damage via formation of protein-bound poly ...
Ben Buelow, Burak Uzunparmak, Marcia Paddock, Andrew M Scharenberg   +3 more
doaj   +1 more source

The Critical Role of PARPs in Regulating Innate Immune Responses

Frontiers in Immunology, 2021
Poly (adenosine diphosphate-ribose) polymerases (PARPs) are a family of proteins responsible for transferring ADP-ribose groups to target proteins to initiate the ADP-ribosylation, a highly conserved and fundamental post-translational modification in all
Huifang Zhu, Yan-Dong Tang, Guoqing Zhan, Chenhe Su, Chunfu Zheng   +4 more
doaj   +1 more source

Olaparib-Induced Purpuric Drug Eruption in a Patient with Castration-Resistant Prostate Cancer

Case Reports in Oncology, 2023
Olaparib is recently approved as an anti-tumor agent for several cancers, including castration-resistant prostate cancer, which inhibits poly (adenosine diphosphate-ribose) polymerase, a DNA repair factor.
Mana Sekine, Hitoshi Terui, Taku Fujimura, Yoshihide Asano   +3 more
doaj   +1 more source

First-Line PARP Inhibitors—Emerging Side Effects Require Caution: A Case of PARPi-Induced Pneumonitis [PDF]

Journal of Immunotherapy and Precision Oncology, 2021
Niraparib, an inhibitor of poly(adenosine diphosphate [ADP]-ribose) 1 and 2, has been shown to improve progression free survival in patients when used as maintenance treatment after first-line platinum-based chemotherapy in advanced stage (III to IV ...
Alistair McLaren, Douglas Cartwright, Ewen Ross, Patricia Roxburgh   +3 more
doaj   +1 more source

PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages

Pathogens, 2023
Aberrant adenosine diphosphate-ribose (ADP)-ribosylation of proteins and nucleic acids is associated with multiple disease processes such as infections and chronic inflammatory diseases. The poly(ADP-ribose) polymerase (PARP)/ADP-ribosyltransferase (ART)
Diego V. Santinelli-Pestana, Elena Aikawa, Sasha A. Singh, Masanori Aikawa   +3 more
doaj   +1 more source

The Antiviral Activities of Poly-ADP-Ribose Polymerases

Viruses, 2021
The poly-adenosine diphosphate (ADP)-ribose polymerases (PARPs) are responsible for ADP-ribosylation, a reversible post-translational modification involved in many cellular processes including DNA damage repair, chromatin remodeling, regulation of ...
Mathilde Malgras, Magali Garcia, Clément Jousselin, Charles Bodet, Nicolas Lévêque   +4 more
doaj   +1 more source

ADP-Ribosylation in Antiviral Innate Immune Response

Pathogens, 2023
Adenosine diphosphate (ADP)-ribosylation is a reversible post-translational modification catalyzed by ADP-ribosyltransferases (ARTs). ARTs transfer one or more ADP-ribose from nicotinamide adenine dinucleotide (NAD+) to the target substrate and release ...
Qian Du, Ying Miao, Wei He, Hui Zheng
doaj   +1 more source

Development of Single-Molecule Electrical Identification Method for Cyclic Adenosine Monophosphate Signaling Pathway

Nanomaterials, 2021
Cyclic adenosine monophosphate (cAMP) is an important research target because it activates protein kinases, and its signaling pathway regulates the passage of ions and molecules inside a cell.
Yuki Komoto, Takahito Ohshiro, Masateru Taniguchi   +2 more
doaj   +1 more source