Results 81 to 90 of about 24,787 (206)

Guidance Statement On BRCA1/2 Tumor Testing in Ovarian Cancer Patients [PDF]

, 2017
International audienceThe approval, in 2015, of the first poly (adenosine diphosphate-ribose) polymerase inhibitor (PARPi; olaparib, Lynparza) for platinum-sensitive relapsed high-grade ovarian cancer with either germline or somatic BRCA1/2 deleterious ...
Banerjee, Susana, Bryce, Jane, Büttner, Reinhard, Capoluongo, Ettore, de Castro, David Gonzalez, Ellison, Gillian, Endris, Volker, Friedman, Eitan, Kamel-Reid, Suzanne, Ligtenberg, Marjolijn J L, Ligtenberg, Marjolijn J.L., López-Guerrero, José Antonio, Markiefka, Birgid, Penault-Llorca, Frédérique, Percival, Natalie, Ray-Coquard, Isabelle, Röthlisberger, Benno, Schirmacher, Peter, Singer, Christian, Soong, Richie, Van Asperen, Christi J, van Asperen, Christi J.   +21 more
core   +4 more sources

Failure to detect "cap" structures in mitochondrial DNA-coded poly(A)-containing RNA from HeLa cells [PDF]

, 1978
The structure of the 5'-termini has been investigated in mitochondrial DNA- coded poly(A)-containing RNA from HeLa cells. For this purpose, mitochondrial RNA isolated from cells labeled for 3 hours with [32P]orthophosphate in the presence of 20 µg/ml ...
Amalric, François, Attardi, Giuseppe, Crews, Stephen, Grohmann, Karel   +3 more
core   +1 more source

Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2 [PDF]

, 2017
Activation of the transient receptor potential melastatin 2 (TRPM2) channel occurs during the response to oxidative stress under physiological conditions as well as in pathological processes such as ischemia and diabetes.
Alim, Ashby, Csanády, Di, Du, Friesner, Gao, Hongwei Jin, Iordanov, Jiang, Jianhong Luo, Jianmin Zhang, Laskowski, Liangren Zhang, Lin-Hua Jiang, Lu, Manna, Massova, Miller, Moreau, Peilin Yu, Perraud, Perraud, Perraud, Qian, Sano, Shen, Song, Starkus, Tan, Tóth, Tóth, Tóth, Uchida, Wei Yang, Weiss, Xiwen Xue, Xupang Hu, Yamamoto, Yan Wu, Yang, Yang, Yang, Ye, Yu, Zhang, Zhenming Liu, Zhou   +47 more
core   +3 more sources

Development of a selection system for the detection of L-ribose isomerase expressing mutants of Escherichia coli [PDF]

, 2007
L-Arabinose isomerase (E.C. 5.3.1.14) catalyzes the reversible isomerization between L-arabinose and L-ribulose and is highly selective towards L-arabinose.
Beauprez, Joeri, De Maeseneire, Sofie, De Mey, Marjan, De Muynck, Cassandra, Soetaert, Wim, Van Bogaert, Inge, Van der Borght, Jef, Vandamme, Erick   +7 more
core   +1 more source

Differential Expression of NUDT9 at Different Phases of The Menstrual Cycle and in Different Components of Normal and Neoplastic Human Endometrium

Taiwanese Journal of Obstetrics & Gynecology, 2009
Objective: The human endometrium manifests different and distinct morphologies and physiologies during the different phases of the menstrual cycle.
Ling-Yun Chen, Tze-Ho Chen, Pao-Ying Wen, Chia-Hung Chou, Tsung-Ho Ying, Shun-Ping Chang, Gwo-Chin Ma, Ming Chen   +7 more
doaj   +1 more source

Enzymic Adenosine Diphosphate Ribosylation of Histone and Poly Adenosine Diphosphate Ribose Synthesis in Rat Liver Nuclei

Journal of Biological Chemistry, 1968
An enzyme associated with mammalian chromatin catalyzed the transfer of the adenosine diphosphate ribose moiety of nicotinamide adenine dinucleotide to histone with the simultaneous release of nicotinamide. A successive transfer of the ADP-ribose moiety resulted in the formation and elongation of a homopolymer with repeating ADP-ribose units ...
Y, Nishizuka, K, Ueda, T, Honjo, O, Hayaishi   +3 more
openaire   +2 more sources

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities [PDF]

, 2013
Poly-ADP-ribosylation is a post-translational modification that regulates processes involved in genome stability. Breakdown of the poly(ADP-ribose) (PAR) polymer is catalysed by poly(ADP-ribose) glycohydrolase (PARG), whose endo-glycohydrolase activity ...
Ahel, Ivan, Ahel, Marijan, Banos, Benito, Barkauskaite, Eva, Brassington, Amy, Dunstan, Mark S., Lafite, Pierre, Leys, David, Mitchison, Timothy J., Tan, Edwin S., Warwicker, Jim   +10 more
core   +2 more sources

First-line treatment of advanced ovarian cancer: an expert update

Libri Oncologici, 2020
Ovarian cancer is the fifth most common cause of death among malignant diseases in women in Europe. The standard treatment is cytoreductive surgery, followed by platinum-taxane based chemotherapy.
Branka Petrić-Miše
doaj   +1 more source

Poly(adenosine diphosphate-ribose) polymerase 1 expression in malignant melanomas from photoexposed areas of the head and neck region. [PDF]

, 2005
Summary The family of the poly(adenosine diphosphate-ribose) polymerase (PARP) proteins is directly involved in genomic stability, DNA repair, and apoptosis by DNA damage.
Argenziano G, Bianco AR, Carlomagno C, De Rosa G., Fabbrocini G, Lo Muzio L, Mascolo M, Molea G, Pepe S, Salvatore G, Scalvenzi M, Somma P, Staibano S   +12 more
core   +1 more source

Effect of 3-aminobenzamide on chromosome damage in human blood lymphocytes adapted to bleomycin [PDF]

, 2017
Human blood lymphocytes, pre-treated with very low (adaptation) concentrations of bleomycin for 48 h and then exposed to a high (challenge) dose of the same agent or X-rays, became significantly less sensitive to the induction of chromosome damage than ...
Burkart, W., Vijayalaxmi,,
core