Clinical significance of adenosine receptor agonists
, 2020 Adenosine is a ubiquitous extracellular signaling molecule with essential functions in human physiology. Adenosine receptors have a widespread expression and extensive effects across different organs.
Adigun, Muhammed Oladimeji
core
Relationship between the Gene Expression of Adenosine Kinase Isoforms and the Expression of CD39 and CD73 Ectonucleotidases in Colorectal Cancer. [PDF]
Acta Naturae, 2023 Zhulai GA, Shibaev MI.
europepmc +1 more source
Advanced Science, EarlyView.This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan +6 more
wiley +1 more source
Cardioprotection following adenosine kinase inhibition in rat hearts
, 2005 Adenosine kinase phosphorylates adenosine to AMP, the primary pathway for adenosine metabolism under basal conditions. Inhibition of adenosine kinase results in a site-specific increase in interstitial adenosine.
J. Gross, Garrett +3 more
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Advanced Science, EarlyView.DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu +6 more
wiley +1 more source
ADENOSINE RECEPTORS IN RESPIRATORY DISORDERS AS CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND MALIGNANT PLEURAL MESOTHELIOMA [PDF]
, 2012 Adenosine is a purine nucleoside that is commonly expressed in the body and involved in a wide range of physiological processes. The effects of adenosine are mediated through specific G-protein coupled cell surface receptors, named A1, A2A, A2B and A3 ...
Targa, Martina
core
Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy
Advanced Science, EarlyView.This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao +5 more
wiley +1 more source
Adenosine kinase promotes post-infarction cardiac repair by epigenetically maintaining reparative macrophage phenotype. [PDF]
J Mol Cell Cardiol, 2023 Zhang M +9 more
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OsCPK12‐OsATPD1 Module Regulates Photosynthetic Acclimation to Light Stress in Rice
Advanced Science, EarlyView.OsCPK12 interacts and phosphorylates OsAtpD1 at Ser8 in its transit peptide. This phosphorylation promote its chloroplast translocation, thereby maintaining ATP synthase activity and proton gradient (ΔpH) homeostasis and regulating photosynthetic acclimation, photoprotection, and repair under light stress.
Beifang Wang +17 more
wiley +1 more source
Adenosine kinase gene expression in human colorectal cancer.
, 2008 Real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to evaluate gene expression of adenosine kinase, a key enzyme in adenosine metabolism, in human intestinal biopsy specimens of 10 colorectal cancer patients.
CHESSA, ANTONELLA +9 more
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