Results 131 to 140 of about 745,257 (254)

The effect of curcumin on PI3K/Akt and AMPK pathways in insulin resistance induced by fructose

Türk Biyokimya Dergisi
Excessive fructose consumption is recognized to elevate insulin resistance in animals and humans. In our study, we aimed to assess the possible consequences of curcumin (curc) treatment applied to rat models of fructose-induced insulin resistance on ...
Kiren Gülce, Severcan Çınar, Severcan Suzan Muratoğlu, Paşaoğlu Hatice   +3 more
doaj   +1 more source

Role of the phosphocreatine system on energetic homeostasis in skeletal and cardiac muscles

Einstein (São Paulo)
Adenosine triphosphate is the present energy currency in the body, and is used in various cellular and indispensable processes for the maintenance of cell homeostasis.
Lucas Guimarães-Ferreira
doaj   +1 more source

Deep brain stimulation suppresses epileptic seizures in rats via inhibition of adenosine kinase and activation of adenosine A1 receptors. [PDF]

CNS Neurosci Ther, 2023
Xie P, Liu S, Huang Q, Xiong Z, Deng J, Tang C, Xu K, Zhang B, He B, Wang X, Liu Z, Wang J, Zhou J, Guan Y, Luan G, Li T, Zhai F.   +16 more
europepmc   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Developmental Role of Adenosine Kinase in the Cerebellum. [PDF]

eNeuro, 2021
Gebril H, Wahba A, Zhou X, Lai T, Alharfoush E, DiCicco-Bloom E, Boison D.   +6 more
europepmc   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Adenosine kinase: A key regulator of purinergic physiology. [PDF]

Biochem Pharmacol, 2021
Boison D, Jarvis MF.
europepmc   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Vagus nerve stimulation exerts disease-modifying effects in epileptic rats by enhancing hippocampal adenosine signalling

Brain Stimulation
Objectives: Vagus nerve stimulation (VNS) is an established neuromodulatory therapy for refractory epilepsy, but its disease-modifying mechanisms remain unclear.
Zhonghua Xiong, Jing Zhang, Ran Gao, Siqi Liu, Xiaoning Zhao, Chongyang Tang, Jiahui Deng, Jing Wang, Qinqin Deng, Minghui Wang, Yujiao Yang, Xiongfei Wang, Yuguang Guan, Jian Zhou, Guoming Luan, Detlev Boison, Xuerong Leng, Tianfu Li   +17 more
doaj   +1 more source