Results 91 to 100 of about 156,709 (208)

Purinergic Signaling in Mast Cell Degranulation and Asthma

Frontiers in Pharmacology, 2017
Mast cells are responsible for the majority of allergic conditions. It was originally thought that almost all allergic events were mediated directly only via the high-affinity immunoglobulin E receptors.
Zhan-Guo Gao, Kenneth A. Jacobson
doaj   +1 more source

A computer generated model of adenosine receptors rationalising binding and selectivity of receptor ligands

, 1991
Computer graphic analyses on a broad spectrum of adenosine receptor ligands has shown that both the A1 and A2 adenosine receptors have three binding sites. The spatial relationship of these three binding sites has been defined.
Jayasuriya, Hiranthi, Quinn, Ronald J., Escher, Andre, Harden, Fiona, Dooley, Michael J.   +4 more
core   +1 more source

Heterómeros de receptores de dopamina. Nuevos mecanismos para la regulación de la transmisión dopaminérgica [PDF]

, 2012
[spa] El Objetivo General de esta Tesis ha sido investigar la formación y función de heterómeros entre receptores de dopamina y otros receptores que puedan estar implicados en la regulación de la transmisión dopaminérgica, como receptores de galanina ...
Moreno Guillén, Estefanía
core  

Structural insights into the agonist selectivity of the adenosine A3 receptor

Nature Communications
Adenosine receptors play pivotal roles in physiological processes. Adenosine A3 receptor (A3R), the most recently identified adenosine receptor, is expressed in various tissues, exhibiting important roles in neuron, heart, and immune cells, and is often ...
Hidetaka S. Oshima, Akiko Ogawa, Fumiya K. Sano, Hiroaki Akasaka, Tomoyoshi Kawakami, Aika Iwama, Hiroyuki H. Okamoto, Chisae Nagiri, Fan-Yan Wei, Wataru Shihoya, Osamu Nureki   +10 more
doaj   +1 more source

Purines and Adenosine Receptors in Osteoarthritis. [PDF]

Biomolecules, 2023
Cronstein BN, Angle SR.
europepmc   +1 more source

Pharmacological and Molecular Characterisation of P2Y Receptors in Endothelial and Epithelial Cells [PDF]

, 2007
Submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyIn light of the significant modulation of receptor activity previously shown by a peptide (designated L247), designed to mimic ...
D’Souza, Vijay Kenneth
core  

Adenosine and Adenosine Enhancers in Treatment of Cardiovascular Diseases

, 2015
Adenosine, the endogenous purine, through its action on four adenosine receptors, is involved in various processes in the heart, such as regulation of the oxygen demand, decrease in sympathetic tone, cell pre-conditioning, inflammation and angiogenesis ...
Noori, Mohammad Saeid
core  

Clinical significance of adenosine receptor agonists

, 2020
Adenosine is a ubiquitous extracellular signaling molecule with essential functions in human physiology. Adenosine receptors have a widespread expression and extensive effects across different organs.
Adigun, Muhammed Oladimeji
core  

The Role of Adenosine Signaling in Obesity-Driven Type 2 Diabetes: Revisiting Mechanisms and Implications for Metabolic Regulation

Diabetology
The global prevalence of obesity and type 2 diabetes has increased considerably in recent decades, primarily due to behavioral changes associated with societal progress, such as increased consumption of high-calorie foods and sedentary lifestyles ...
Giuseppe Faraco, Joana M. Gaspar
doaj   +1 more source

Pharmacology of Adenosine Receptors: Recent Advancements. [PDF]

Biomolecules, 2023
Vincenzi F, Pasquini S, Contri C, Cappello M, Nigro M, Travagli A, Merighi S, Gessi S, Borea PA, Varani K.   +9 more
europepmc   +1 more source