Results 161 to 170 of about 761,976 (296)

Molecular Simulations and Drug Discovery of Adenosine Receptors. [PDF]

Molecules, 2022
Wang J, Bhattarai A, Do HN, Akhter S, Miao Y.   +4 more
europepmc   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Thermodinamic Analysis in Drug-receptor Binding: The A3 Adenosine receptor

, 2010
Receptor binding thermodynamics is a powerful tool to gain deep insight, at the molecular level, of the events which occur during drug-receptor interactions.
GESSI, Stefania, BOREA, Pier Andrea, VARANI, Katia, MERIGHI, Stefania   +3 more
core  

Synthesis of novel 1,2,4-oxadiazole-isoxazoline hybrids and their in silico potential with adenosine receptors. [PDF]

Beilstein J Org Chem
Mohammed PS, Dalo MKS, Yazıcı OC, Yildirim M, Sağırlı A.   +4 more
europepmc   +1 more source

The CXCL5/CXCR2 Axis Attenuates Ferroptosis in Intrahepatic Cholangiocarcinoma Through the Positive Feedback Loop Between PTGS2 Transcriptional Activation and Neutrophil Recruitment

Advanced Science, EarlyView.
The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye, Kefeng Lin, Shuyao Yang, Yan Zhang, Wenli Gao, Jiaqi Chen, Ying Dong, Rui Bai, Yang Tian, Minghao Wang, Zhijun Yuan, Yuxiao Ma, Yuqin He, Ruyin Chen, Wenguang Fu, Qi Jiang, Qiong Li, Jian Ruan   +17 more
wiley   +1 more source

Adenosine Receptors in Neuroinflammation and Neurodegeneration. [PDF]

Cells
Salmaso V, Menin S, Moro S, Spalluto G, Federico S.   +4 more
europepmc   +1 more source

Update on the recent development of allosteric modulators for adenosine receptors and their therapeutic applications. [PDF]

Front Pharmacol, 2022
Pasquini S, Contri C, Cappello M, Borea PA, Varani K, Vincenzi F.   +5 more
europepmc   +1 more source

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

Role of Adenosine Receptors in Sleep Deprivation-Induced Depression-Like Behaviors. [PDF]

Biomol Ther (Seoul)
Lee NJ, Jung YS.
europepmc   +1 more source

Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage. [PDF]

Int J Mol Sci, 2022
Valada P, Alçada-Morais S, Cunha RA, Lopes JP.   +3 more
europepmc   +1 more source