Results 171 to 180 of about 761,976 (296)

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Adenosine receptors on the immuno-oncology expressway: TIME, perspectives, and translation. [PDF]

Front Immunol
Majumder B, Datta S.
europepmc   +1 more source

A 2A ADENOSINE RECEPTORS REGULATE MULTIPLE ORGAN FAILURE AFTER HEMORRHAGIC SHOCK IN MICE. [PDF]

Shock, 2022
Kelestemur T, Németh ZH, Pacher P, Antonioli L, Haskó G.   +4 more
europepmc   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, EarlyView.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source

Special Issue "Molecular Research on Adenosine Receptors: From Cell Biology to Human Diseases". [PDF]

Int J Mol Sci
Mannino F.
europepmc   +1 more source

Enviromics and Abiotic Enviromics: Enhancing Stress Biology and Plant Resilience Breeding

Advanced Science, EarlyView.
Environmental stressors are captured through high‐throughput envirotyping and integrated into an enviromic framework with genomic, transcriptomic, phenomic, and environmental data. AI/ML models enable prediction and guide marker‐assisted selection, genomic selection, genome editing, and gene pyramiding toward improved abiotic stress tolerance, yield ...
Guangchao Sun, Jose Luis Araus, James C. Schnable, Jie Xu, Henry T. Nguyen, Yunbi Xu, Yanli Lu   +6 more
wiley   +1 more source

Adenosine and adenosine receptors: a "double-edged sword" in cardiovascular system. [PDF]

Front Pharmacol
Qian Y, Zheng Y, Leng L, Liu Q, Tian X, Chen S, Zhang S, Xie J.   +7 more
europepmc   +1 more source

Adenosine receptors differentially mediate enteric glial cell death induced by Clostridioides difficile Toxins A and B. [PDF]

Front Immunol, 2022
Costa DVS, Shin JH, Goldbeck SM, Bolick DT, Mesquita FS, Loureiro AV, Rodrigues-Jesus MJ, Brito GAC, Warren CA.   +8 more
europepmc   +1 more source

Organic Nanozyme‐Embedded Biotherapeutic Thermosensitive Hydrogel for Extracellular GSH Depletion and Postoperative Tumor Suppression

Advanced Science, EarlyView.
A temperature‐sensitive hydrogel loaded with cyanine nanozymes and Escherichia coli is locally injected into postoperative tumor resection beds. Upon light irradiation, synergistic PTT and PDT work with cascaded reactive oxygen species to deplete extracellular GSH, eliminate residual tumor cells, and induce robust antitumor immune responses for ...
Cong Jiang, Zifan Yang, Rong Guo, Meng Suo, Guowei Wang, Dong Chen, Lilin Su, Fuhuan Wang, Shipeng Ning, Kelong Fan, Xuan Wang   +10 more
wiley   +1 more source

Adenosine receptors and acute kidney injury: perspectives for future therapy. [PDF]

Purinergic Signal
Wissmann IB, Coelho RCD, Baseggio L, Cardoso AM.   +3 more
europepmc   +1 more source