Results 31 to 40 of about 35,275 (163)

Sequence homology between avian and human adenoviruses [PDF]

Journal of Virology, 1982
Studies of hybridization between fowl adenovirus type 1 (chicken embryo lethal orphan virus) DNA and human adenovirus type 2 DNA revealed two short but distinct regions which cross-hybridized under stringent conditions. One of the homologous regions was located between map positions 18.1 and 19.3 and did not correspond to any gene recognized so far ...
P, Aleström, A, Stenlund, P, Li, A, Bellett, U, Pettersson   +4 more
openaire   +2 more sources

Downmodulation of El A Protein Expression as a Novel Strategy to Design Cancer-Selective Adenoviruses

Neoplasia: An International Journal for Oncology Research, 2005
Oncolytic adenoviruses are being tested as potential therapies for human malignant tumors, including gliomas. Here we report for the first time that a mutation in the E1A gene results in low levels of ElA protein, conditioning the replication of mutant ...
Hong Jiang, Ramon Alemany, Candelaria Gomez-Manzano, Diana R. Medrano, Michael G. Lemoine, Melissa V. Olson, Marta M. Alonso, Ok-Hee Lee, Charles C. Conrad, W.K. Alfred Yung, Juan Fueyo   +10 more
doaj   +1 more source

Development of replication-deficient adenovirus malaria vaccines

Expert Review of Vaccines, 2017
Introduction: Malaria remains a major threat to endemic populations and travelers, including military personnel to these areas. A malaria vaccine is feasible, as radiation attenuated sporozoites induce nearly 100% efficacy.
Michael R. Hollingdale, Martha Sedegah, Keith Limbach   +2 more
doaj   +1 more source

The Oncogenicity of Human Adenoviruses in Hamsters

Experimental Biology and Medicine, 1968
In 1962 we reported that human adenovirus type 12 induces undifferentiated sarcomas at the site of injection into newborn hamsters in high incidence and after a very short latent period (1,2). Extensive attempts to recover virus from such tumors have been negative in this and several other laboratories (3,4), although Connor et al.
J J, Trentin, G L, Van Hoosier, L, Samper   +2 more
openaire   +2 more sources

Predicting the Next Eye Pathogen: Analysis of a Novel Adenovirus

mBio, 2013
For DNA viruses, genetic recombination, addition, and deletion represent important evolutionary mechanisms. Since these genetic alterations can lead to new, possibly severe pathogens, we applied a systems biology approach to study the pathogenicity of a ...
Christopher M. Robinson, Xiaohong Zhou, Jaya Rajaiya, Mohammad A. Yousuf, Gurdeep Singh, Joshua J. DeSerres, Michael P. Walsh, Sallene Wong, Donald Seto, David W. Dyer, James Chodosh, Morris S. Jones   +11 more
doaj   +1 more source

Double suicide genes selectively kill human umbilical vein endothelial cells

Virology Journal, 2011
Background To construct a recombinant adenovirus containing CDglyTK double suicide genes and evaluate the killing effect of the double suicide genes driven by kinase domain insert containing receptor (KDR) promoter on human umbilical vein endothelial ...
Liu Lunxu, Wang Yanping, Mei Longyong, Jia Weiguo, Che Guowei   +4 more
doaj   +1 more source

In vitro and in vivo tropism and biodistribution of recombinant simian adenovirus type 25

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. Recombinant adenoviruses are widely used in the development of vaccines for a variety of infectious diseases. Despite numerous clinical studies, only a few types of human (types 5 and 26) and simian (isolate Y25) adenoviruses are currently ...
Irina V. Vavilova, Tatiana A. Ozharovskaia, Olga V. Zubkova, Olga Popova, Daria V. Voronina, Polina P. Goldovskaya, Denis I. Zrelkin, Alina Sh. Dzharullaeva, Inna V. Dolzhikova, Dmitry V. Shcheblyakov, Denis Yu. Logunov, Alexander L. Gintsburg   +11 more
doaj   +1 more source

Comparative Effect of Oncolytic Adenoviruses with E1 A or E113-55 kDa Deletions in Malignant Gliomas

Neoplasia: An International Journal for Oncology Research, 2005
Replication-competent oncolytic adenoviruses hold considerable promise for treating malignant gliomas. The toxicity of the clinically tested Ell B-55 kDa mutant virus is negligible; however, its full clinical potential is still being evaluated.
Hong Jiang, Candelaria Gomez-Manzano, Ramon Alemany, Diana Medrano, Marta Alonso, B. Nebiyou Bekele, E Lin, Charles C. Conrad, W.K. Alfred Yung, Juan Fueyo   +9 more
doaj   +1 more source

Latent Species C Adenoviruses in Human Tonsil Tissues [PDF]

Journal of Virology, 2009
ABSTRACT Although species C human adenoviruses establish persistent infections, the molecular details of this lifestyle remain poorly understood. We previously reported that adenovirus DNA is found in human mucosal T lymphocytes in a noninfectious form (C. T. Garnett, D. Erdman, W. Xu, and L. R. Gooding, J. Virol.
C T, Garnett, G, Talekar, J A, Mahr, W, Huang, Y, Zhang, D A, Ornelles, L R, Gooding   +6 more
openaire   +2 more sources

Oncolytic adenoviruses as a therapeutic approach for osteosarcoma: A new hope

Journal of Bone Oncology, 2017
Osteosarcoma is the most common bone cancer among those with non-hematological origin and affects mainly pediatric patients. In the last 50 years, refinements in surgical procedures, as well as the introduction of aggressive neoadjuvant and adjuvant ...
Marc Garcia-Moure, Naiara Martinez-Vélez, Ana Patiño-García, Marta M. Alonso   +3 more
doaj   +1 more source