Expression and functions of adenylyl cyclases in the CNS [PDF]
Fluids and Barriers of the CNS, 2022 Adenylyl cyclases (ADCYs), by generating second messenger cAMP, play important roles in various cellular processes. Their expression, regulation and functions in the CNS, however, remain largely unknown.
Karan Devasani, Yao Yao
doaj +4 more sources
New Perspectives on Plant Adenylyl Cyclases [PDF]
Frontiers in Molecular Biosciences, 2019 It is increasingly clear that plant genomes encode numerous complex multidomain proteins that harbor functional adenylyl cyclase (AC) centers. These AC containing proteins have well-documented roles in development and responses to the environment ...
Oziniel Ruzvidzo +2 more
doaj +5 more sources
Ca2+-stimulated adenylyl cyclases as therapeutic targets for psychiatric and neurodevelopmental disorders [PDF]
Frontiers in Pharmacology, 2022 As the main secondary messengers, cyclic AMP (cAMP) and Ca2+ trigger intracellular signal transduction cascade and, in turn, regulate many aspects of cellular function in developing and mature neurons. The group I adenylyl cyclase (ADCY, also known as AC)
Jiao Chen +3 more
doaj +2 more sources
Photoactivated adenylyl cyclases attenuate sepsis-induced cardiomyopathy by suppressing macrophage-mediated inflammation [PDF]
Frontiers in Immunology, 2022 Sepsis-induced myocardiopathy, characterized by innate immune cells infiltration and proinflammatory cytokines release, may lead to perfusion failure or even life-threatening cardiogenic shock.
Guofang Xia +7 more
doaj +2 more sources
Optogenetic manipulation of neuronal and cardiomyocyte functions in zebrafish using microbial rhodopsins and adenylyl cyclases [PDF]
eLife, 2023 Even though microbial photosensitive proteins have been used for optogenetics, their use should be optimized to precisely control cell and tissue functions in vivo.
Hanako Hagio +10 more
doaj +2 more sources
Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases [PDF]
eLife, 2022 Mycobacterium tuberculosis adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor of the mammalian membrane ACs and a model system for studies of their structure and function.
Ved Mehta +9 more
doaj +2 more sources
The membrane domains of mammalian adenylyl cyclases are lipid receptors [PDF]
eLifeThe biosynthesis of cyclic 3′,5′-adenosine monophosphate (cAMP) by mammalian membrane-bound adenylyl cyclases (mACs) is predominantly regulated by G-protein-coupled receptors (GPCRs).
Marius Landau +5 more
doaj +2 more sources
Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling in Dictyostelium [PDF]
CellsDictyostelium is a unique model used to study the complex and interactive cyclic nucleotide signaling pathways that regulate multicellular development.
Pundrik Jaiswal, Alan R. Kimmel
doaj +2 more sources
Emerging Evidence for cAMP-calcium Cross Talk in Heart Atrial Nanodomains Where IP-Evoked Calcium Release Stimulates Adenylyl Cyclases [PDF]
Contact, 2021 Calcium handling is vital to normal physiological function in the heart. Human atrial arrhythmias, eg. atrial fibrillation, are a major morbidity and mortality burden, yet major gaps remain in our understanding of how calcium signaling pathways function ...
Rebecca-Ann B. Burton, Derek A. Terrar
doaj +2 more sources
Adenylyl cyclases in the digestive system. [PDF]
Cell Signal, 2014 Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca(2+) and other intracellular signals.
Sabbatini ME, Gorelick F, Glaser S.
europepmc +5 more sources