Results 91 to 100 of about 83,442 (296)
Central role of soluble adenylyl cyclase and cAMP in sperm physiology [PDF]
, 2014 Cyclic adenosine 3′,5′-monophosphate (cAMP), the first second messenger to be described, plays a central role in cell signaling in a wide variety of cell types.
Buffone, Mariano Gabriel +3 more
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Journal of Biological Chemistry, 2009 Nine membrane-bound mammalian adenylyl cyclases (ACs) have been identified. Type 1 and 8 ACs (AC1 and AC8), which are both expressed in the brain and are stimulated by Ca2+/calmodulin (CaM), have discrete neuronal functions. Although the Ca2+ sensitivity
N. Masada +3 more
semanticscholar +1 more source
Luteinizing hormone receptor knockout mouse: What has it taught us?
Andrology, EarlyView.Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley +1 more source
Compartmentalization of distinct cAMP signaling pathways in mammalian sperm. [PDF]
, 2013 Fertilization competence is acquired in the female tract in a process known as capacitation. Capacitation is needed for the activation of motility (e.g. hyperactivation) and to prepare the sperm for an exocytotic process known as acrosome reaction. While
Buck, Jochen +12 more
core +1 more source
Physiological Sensing of Carbon Dioxide/Bicarbonate/pH via Cyclic Nucleotide Signaling
Sensors, 2011 Carbon dioxide (CO2) is produced by living organisms as a byproduct of metabolism. In physiological systems, CO2 is unequivocally linked with bicarbonate (HCO3−) and pH via a ubiquitous family of carbonic anhydrases, and numerous biological processes are
Lonny R. Levin, Jochen Buck
doaj +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose The pattern recognition receptors, formyl peptide receptors, FPR1 and FPR2, are G protein‐coupled receptors that recognize many different pathogen‐ and host‐derived ligands. While FPR1 conveys pro‐inflammatory signals, FPR2 is linked with pro‐resolving outcomes.
Denise Pajonczyk +5 more
wiley +1 more source
ADENYLYL CYCLASE TYPE 9: REGULATION AND CARDIAC FUNCTION [PDF]
, 2018 Abnormalities in cardiac stress signaling underlie a number of cardiovascular diseases (e.g. arrhythmias and heart failure). Cardiac stress signaling pathways normally integrate signals from the sympathetic nervous system to promote efficient contraction
Baldwin, Tanya A., Baldwin, Tanya A.
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Aldosterone signaling and soluble adenylyl cyclase—A nexus for the kidney and vascular endothelium [PDF]
, 2014 The steroid hormone aldosterone regulates the reabsorption of water and ions in the kidney and plays a central role in blood pressure regulation and homeostasis.
Brand, Eva +2 more
core +1 more source
Opioid receptors in cardiovascular function
British Journal of Pharmacology, EarlyView.Opioid receptors are G protein‐coupled receptors expressed by various cells in the heart, including myocytes and nerve fibres, and play a crucial role in modulating cardiac function. These receptors influence neural transmission, heart rate and myocyte contractility, offering cardioprotection.
Venkatesh Katari +4 more
wiley +1 more source
The Enigmatic Canal-Associated Neurons Regulate Caenorhabditis elegans Larval Development Through a cAMP Signaling Pathway. [PDF]
, 2019 Caenorhabditis elegans larval development requires the function of the two Canal-Associated Neurons (CANs): killing the CANs by laser microsurgery or disrupting their development by mutating the gene ceh-10 results in early larval arrest. How these cells
Chien, Jason +5 more
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