Results 111 to 120 of about 12,144 (214)

Structural analysis of the NifL‐NifA complex reveals the molecular basis of anti‐activation of nitrogen fixation gene expression in Azotobacter vinelandii

The FEBS Journal, EarlyView.
Using cryo‐EM combined with biochemical and genetic approaches, we mapped the interaction surface between NifL and NifA to gain insights into the regulation of nitrogen fixation genes in A. vinelandii. Our findings suggest that NifL, a homolog of histidine kinases lacking phosphorylation activity, evolved to act as a steric block of NifA activity ...
Marcelo Bueno Batista, Jake Richardson, Michael W. Webster, Dmitry Ghilarov, John W. Peters, David M. Lawson, Ray Dixon   +6 more
wiley   +1 more source

Co-Localization of p-CREB and p-NR1 in Spinothalamic Neurons in a Chronic Muscle Pain Model [PDF]

, 2007
Activation of the cAMP pathway is an important mediator of chronic muscle pain. This study examined phosphorylation of the transcription factor cAMP-response-element-binding protein (p-CREB) and the NR1 subunit of the NMDA receptor (p-NR1) in the spinal ...
Bement, Marie K. Hoeger, Sluka, Kathleen A.   +1 more
core   +2 more sources

The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus

The FEBS Journal, EarlyView.
The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen, Jan Eric Maika, Raphael Josef Eberle, Nina Jahnke, Marcel Wiermer, Laura Hartmann, Rüdiger Simon, Georg Groth   +7 more
wiley   +1 more source

Trichomonas transmembrane cyclases result from massive gene duplication and concomitant development of pseudogenes.

PLoS Neglected Tropical Diseases, 2010
BackgroundTrichomonas vaginalis has an unusually large genome (approximately 160 Mb) encoding approximately 60,000 proteins. With the goal of beginning to understand why some Trichomonas genes are present in so many copies, we characterized here a family
Jike Cui, Suchismita Das, Temple F Smith, John Samuelson   +3 more
doaj   +1 more source

Involvement of protein kinase A in patterning of the mouse somatosensory cortex [PDF]

, 2006
Patterning of the mouse somatosensory cortex is unusually evident because of the presence of a "barrel field." Presynaptic serotonin and postsynaptic glutamate receptors regulate barrel formation, but little is known of the intracellular signaling ...
Abdel-Majid, Raja M, Barnett, Mark W, Gillingwater, Thomas H, Katsnelson, Alla, Kind, Peter C, McKnight, G Stanley, Neumann, Paul E, Watson, Ruth F, Willis, Brandon S   +8 more
core   +1 more source

Unlocking nitrogen regulation: structural insights into the NifL‐NifA complex and prospects for engineered diazotrophs

The FEBS Journal, EarlyView.
The urgent need for sustainable agriculture places biological nitrogen fixation at the forefront of current biotechnological research. Plant growth‐promoting rhizobacteria play crucial roles in agriculture by enhancing nutrient absorption, regulating hormonal balance, and providing reduced nitrogen to plants. Among these, diazotrophic bacteria, such as
Edileusa Cristina Marques Gerhardt, Khaled A. Selim   +1 more
wiley   +1 more source

Chemo- and Thermosensory Responsiveness of Grueneberg Ganglion Neurons Relies on Cyclic Guanosine Monophosphate Signaling Elements [PDF]

, 2011
Neurons of the Grueneberg ganglion (GG) in the anterior nasal region of mouse pups respond to cool temperatures and to a small set of odorants. While the thermosensory reactivity appears to be mediated by elements of a cyclic guanosine monophosphate ...
Berghard A, Biel M, Biron D, Brechbühl J, Breer H, Chao YC, Duda T, Fleischer J, Fleischer J, Fleischer J, Fleischer J, Fleischer J, Fuss SH, Grosmaitre X, Grota LJ, Guo D, Halem HA, Halpern M, Heinz Breer, Hu J, Jia C, Joerg Fleischer, Katharina Mamasuew, Kimoto H, Kimoto H, Koos DS, Krieger J, Kuhara A, Kuhn M, Leinders-Zufall T, Lin H, Liu CY, Ma M, Mamasuew K, Mamasuew K, Mamasuew K, Martin Biel, Matsuoka M, Munger SD, Munger SD, Nina Hofmann, Norlin EM, Roppolo D, Ruey-Bing Yang, Schmid A, Storan MJ, Sun L, Verena Kretzschmann   +47 more
core   +2 more sources

Characterization of the Blue-Light-Activated Adenylyl Cyclase mPAC by Flash Photolysis and FTIR Spectroscopy [PDF]

, 2017
The recently discovered photo-activated adenylyl cyclase (mPAC from Microcoleus chthonoplastes) is the first PAC that owes a light-, oxygen- and voltage-sensitive (LOV) domain for blue-light sensing.
Alexandre, Ataka, Bauer, Bednarz, Biasini, Bordoli, Buttani, Christie, El-Arab, Fedorov, Harper, Herman, Herman, Iseki, Iwata, Iwata, Iwata, Jurk, Kelley, Kerruth, Kikuchi, Kottke, Lee, Liu, Lokhandwala, Looser, Losi, Losi, Moglich, Nakasone, Pfeifer, Pfeifer, Raffelberg, Raffelberg, Salomon, Sato, Schröder-Lang, Stierl, Swartz, Taylor, Thöing, Yoshikawa   +41 more
core   +2 more sources

New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway.

Frontiers in Pharmacology, 2015
G protein-coupled receptors (GPCR) linked to stimulatory G (Gs) proteins (GsPCR) mediate increases in intracellular cyclic AMP as consequence of activation of nine adenylyl cyclases (AC), which differ considerably in their cellular distribution and ...
Rosely Oliveira Godinho, Thiago eDuarte, Enio Setsuo Arakaki Pacini   +2 more
doaj   +1 more source

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na+/K+‐ATPase and K+ Channel Activity

Annals of the New York Academy of Sciences, EarlyView.
Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg, Erdene Baigal, Anny Leung, Gert‐Jan Kremers, Marcel J. C. Bijvelds   +4 more
wiley   +1 more source