Results 111 to 120 of about 16,663 (278)

Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach [PDF]

, 2008
BACKGROUND: Calmodulin is an important multifunctional molecule that regulates the activities of a large number of proteins in the cell. Calcium binding induces conformational transitions in calmodulin that make it specifically active to particular ...
Bates, Declan, Heslop-Harrison, Pat, Kotov, Nikolay, Postlethwaite, Ian, Valeyev, Najil   +4 more
core   +5 more sources

Unlocking nitrogen regulation: structural insights into the NifL‐NifA complex and prospects for engineered diazotrophs

The FEBS Journal, EarlyView.
The urgent need for sustainable agriculture places biological nitrogen fixation at the forefront of current biotechnological research. Plant growth‐promoting rhizobacteria play crucial roles in agriculture by enhancing nutrient absorption, regulating hormonal balance, and providing reduced nitrogen to plants. Among these, diazotrophic bacteria, such as
Edileusa Cristina Marques Gerhardt, Khaled A. Selim   +1 more
wiley   +1 more source

Trichomonas transmembrane cyclases result from massive gene duplication and concomitant development of pseudogenes.

PLoS Neglected Tropical Diseases, 2010
BackgroundTrichomonas vaginalis has an unusually large genome (approximately 160 Mb) encoding approximately 60,000 proteins. With the goal of beginning to understand why some Trichomonas genes are present in so many copies, we characterized here a family
Jike Cui, Suchismita Das, Temple F Smith, John Samuelson   +3 more
doaj   +1 more source

Characterization of the Blue-Light-Activated Adenylyl Cyclase mPAC by Flash Photolysis and FTIR Spectroscopy [PDF]

, 2017
The recently discovered photo-activated adenylyl cyclase (mPAC from Microcoleus chthonoplastes) is the first PAC that owes a light-, oxygen- and voltage-sensitive (LOV) domain for blue-light sensing.
Alexandre, Ataka, Bauer, Bednarz, Biasini, Bordoli, Buttani, Christie, El-Arab, Fedorov, Harper, Herman, Herman, Iseki, Iwata, Iwata, Iwata, Jurk, Kelley, Kerruth, Kikuchi, Kottke, Lee, Liu, Lokhandwala, Looser, Losi, Losi, Moglich, Nakasone, Pfeifer, Pfeifer, Raffelberg, Raffelberg, Salomon, Sato, Schröder-Lang, Stierl, Swartz, Taylor, Thöing, Yoshikawa   +41 more
core   +2 more sources

Functional Non‐Nucleoside Adenylyl Cyclase Inhibitors

Chemical Biology & Drug Design, 2014
In this study, we describe the synthesis of novel functional non‐nucleoside adenylyl cyclase inhibitors, which can be easily modified with thiol containing biomolecules such as tumour targeting structures. The linkage between inhibitor and biomolecule contains cleavable bonds to enable efficient intracellular delivery in the reductive milieu of the ...
Lelle, M., Hameed, A., Ackermann, L., Kaloyanova, S., Wagner, M., Berisha, F., Nikolaev, V., Peneva, K.   +7 more
openaire   +4 more sources

Involvement of protein kinase A in patterning of the mouse somatosensory cortex [PDF]

, 2006
Patterning of the mouse somatosensory cortex is unusually evident because of the presence of a "barrel field." Presynaptic serotonin and postsynaptic glutamate receptors regulate barrel formation, but little is known of the intracellular signaling ...
Abdel-Majid, Raja M, Barnett, Mark W, Gillingwater, Thomas H, Katsnelson, Alla, Kind, Peter C, McKnight, G Stanley, Neumann, Paul E, Watson, Ruth F, Willis, Brandon S   +8 more
core   +1 more source

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na+/K+‐ATPase and K+ Channel Activity

Annals of the New York Academy of Sciences, EarlyView.
Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg, Erdene Baigal, Anny Leung, Gert‐Jan Kremers, Marcel J. C. Bijvelds   +4 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +15 more sources

Cardiac-Directed Expression of Adenylyl Cyclase Catalytic Domain ( C1C2 ) Attenuates Deleterious Effects of Pressure Overload [PDF]

, 2019
Zhen Tan, Dimosthenis Giamouridis, N. Chin Lai, Young Chul Kim, Tracy Guo, Bing Xia, Mei Hua Gao, H. Kirk Hammond   +7 more
openalex   +1 more source

Mandibular Condylar Cartilage in Development and Diseases: A PTHrP‐Centric View

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT The mandibular condylar cartilage (MCC) is a dual‐function component of the temporomandibular joint (TMJ), acting as both articular cartilage for jaw movement and growth cartilage for vertical growth of the mandibular condyle. Parathyroid hormone‐related protein (PTHrP) plays a critical role in orchestrating chondrogenesis in the long bone ...
Chiaki Tsutsumi‐Arai, Amy Tran, Yuki Arai, Wanida Ono, Noriaki Ono   +4 more
wiley   +1 more source