Results 121 to 130 of about 16,663 (278)

New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway.

Frontiers in Pharmacology, 2015
G protein-coupled receptors (GPCR) linked to stimulatory G (Gs) proteins (GsPCR) mediate increases in intracellular cyclic AMP as consequence of activation of nine adenylyl cyclases (AC), which differ considerably in their cellular distribution and ...
Rosely Oliveira Godinho, Thiago eDuarte, Enio Setsuo Arakaki Pacini   +2 more
doaj   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

Roles of Cyclic Nucleotide Phosphodiesterases in Signal Transduction Pathways in the Nematode Caenorhabditis elegans

Cells
Cyclic nucleotide signaling pathways play essential roles in the physiology of the nematode Caenorhabditis elegans, influencing processes such as reproduction, environmental sensing, and cellular homeostasis. The intracellular levels of cAMP and cGMP are
Kranti K. Galande, Rick H. Cote
doaj   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Measurement of Intracellular cAMP Levels Using the Cyclic Nucleotide XP Enzymatic Immunoassay Kit in Bacteria

Bio-Protocol, 2016
Cyclic AMP (cAMP) is a ubiquitous secondary signaling molecule, commonly associated with many bacterial processes, including the regulation of virulence factors, such as biofilms, pellicles and motility (Wolfgang, 2003). The quantity of available cAMP is
Sarah Giles, Uwe Stroeher, Melissa Brown
doaj   +1 more source

The Love Story between Orai Calcium Entry Channels and Adenylyl Cyclases Gets even more Complicated. [PDF]

Function (Oxf), 2021
Hofer AM.
europepmc   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Adenylyl cyclases types 1 and 8 promote pro-survival pathways after ethanol exposure in the neonatal brain

Neurobiology of Disease, 2009
Although a wide range of developmental disabilities following fetal alcohol exposure are observed clinically, the molecular factors that determine the severity of these sequelae remain undefined. In mice exposed to ethanol, deletion of adenylyl cyclases (
Alana C. Conti, Chainllie Young, John W. Olney, Louis J. Muglia   +3 more
doaj   +1 more source

Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis

The Journal of Physiology, EarlyView.
Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal. Abstract If we consider neurons like muscles during exercise, the demand for oxygen (O2) and carbon dioxide (CO2) elimination is constantly changing.
Isabel N. Christie
wiley   +1 more source

Mycobacterial STAND adenylyl cyclases: The HTH domain binds DNA to form biocrystallized nucleoids. [PDF]

Biophys J, 2021
Zaveri A, Bose A, Sharma S, Rajendran A, Biswas P, Shenoy AR, Visweswariah SS.   +6 more
europepmc   +1 more source