Hypoxia induces cancer-associated cAMP/PKA signalling through HIF-mediated transcriptional control of adenylyl cyclases VI and VII. [PDF]
Sci Rep, 2017 Hypoxia is a phenomenon often arising in solid tumours, linked to aggressive malignancy, bad prognosis and resistance to therapy. Hypoxia-inducible factor-1 has been identified as a key mediator of cell and tissue adaptation to hypoxic conditions through
Simko V +8 more
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Ciliary adenylyl cyclases control the Hedgehog pathway [PDF]
Journal of Cell Science, 2015 Protein kinase A (PKA) accumulates at the base of the cilium where it negatively regulates the Hedgehog (Hh) pathway. Although PKA activity is essentially controlled by the cAMP produced by adenylyl cyclases, the influence of these enzymes on the Hh ...
L. Vuolo +4 more
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The membrane domains of mammalian adenylyl cyclases are lipid receptors [PDF]
eLifeThe biosynthesis of cyclic 3′,5′-adenosine monophosphate (cAMP) by mammalian membrane-bound adenylyl cyclases (mACs) is predominantly regulated by G-protein-coupled receptors (GPCRs).
Marius Landau +5 more
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Structural basis of adenylyl cyclase 9 activation [PDF]
Nature Communications, 2022 Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzymes ...
Chao Qi +12 more
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Distinct mechanisms of calmodulin binding and regulation of adenylyl cyclases 1 and 8. [PDF]
Biochemistry, 2012 Calmodulin (CaM), by mediating the stimulation of the activity of two adenylyl cyclases (ACs), plays a key role in integrating the cAMP and Ca2+ signaling systems.
Masada N +4 more
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Emerging Evidence for cAMP-calcium Cross Talk in Heart Atrial Nanodomains Where IP-Evoked Calcium Release Stimulates Adenylyl Cyclases [PDF]
Contact, 2021 Calcium handling is vital to normal physiological function in the heart. Human atrial arrhythmias, eg. atrial fibrillation, are a major morbidity and mortality burden, yet major gaps remain in our understanding of how calcium signaling pathways function ...
Rebecca-Ann B. Burton, Derek A. Terrar
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Adenylyl cyclases in the digestive system. [PDF]
Cell Signal, 2014 Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca(2+) and other intracellular signals.
Sabbatini ME, Gorelick F, Glaser S.
europepmc +5 more sources
Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling in Dictyostelium [PDF]
CellsDictyostelium is a unique model used to study the complex and interactive cyclic nucleotide signaling pathways that regulate multicellular development.
Pundrik Jaiswal, Alan R. Kimmel
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Regulation by Ca2+-signaling pathways of adenylyl cyclases. [PDF]
Cold Spring Harb Perspect Biol, 2011 Interplay between the signaling pathways of the intracellular second messengers, cAMP and Ca(2+), has vital consequences for numerous essential physiological processes. Although cAMP can impact on Ca(2+)-homeostasis at many levels, Ca(2+) either directly,
Halls ML, Cooper DM.
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Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014 The second messenger cyclic adenosine 3',5'-monophosphate (cAMP) regulates a wide range of physiological processes in almost all organisms. cAMP synthesis is catalyzed by adenylyl cyclases (ACs). All ten mammalian AC isoenzymes (AC1-10) belong to AC Class III, which is defined by sequence homologies in the catalytic domains. Nevertheless, the mammalian
C. Steegborn
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