Results 31 to 40 of about 4,802 (96)
Chemical Biology &Drug Design, Volume 101, Issue 2, Page 340-349, February 2023., 2023 Non‐cytotoxic C2‐linked alkynyl oligo ethylene glycol adenosine conjugates are highly water soluble and stimulate adenosine receptor activity. Abstract A series of 12 novel polyethylene‐glycol(PEG)‐alkynyl C2‐adenosine(ADN) conjugates were synthesized using a robust Sonogashira coupling protocol and characterized by NMR spectroscopy and mass ...
Lindsay Ferguson +8 more
wiley +1 more source
Opioid regulation of Mu receptor internalisation: relevance to the development of tolerance and dependence [PDF]
, 2010 Internalisation of the mu opioid receptor from the surface of cells is generally achieved by receptor occupancy with agonist ligands of high efficacy. However, in many situations the potent analgesic morphine fails to promote internalisation effectively ...
Lopez-Gimenez, J.F., Milligan, G.
core +2 more sources
European Journal of Neuroscience, Volume 56, Issue 12, Page 6141-6161, December 2022., 2022 Chemical synapses are tiny and overcrowded environments enriched with thousands of protein species. Many efforts have been devoted to developing sensors and actuators able to evaluate and control synaptic communication. Most of these recent tools are based on the engineering of one or more specific synaptic proteins used to target active moieties to ...
Jacopo Lamanna +3 more
wiley +1 more source
Modulation of sensory information processing by a neuroglobin in C. elegans [PDF]
, 2016 Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. We show that in the C. elegans URX O2 sensing neurons two putative molecular O2 sensors, a neuroglobin and O2-binding soluble guanylate cyclases, work antagonistically to sculpt a slowly ...
arxiv +1 more source
Separate roles of PKA and EPAC in renal function unraveled by the optogenetic control of cAMP levels in vivo [PDF]
, 2013 Cyclic AMP (cAMP) is a ubiquitous second messenger that regulates a variety of essential processes in diverse cell types, functioning via cAMP-dependent effectors such as protein kinase A (PKA) and/or exchange proteins directly activated by cAMP (EPAC ...
Akbari +60 more
core +1 more source
An investigation of the response of a model class IIIA Adenyly Cyclase to carbon dioxide [PDF]
, 2009 Adenylyl cyclase catalyses the conversion of adenosine triphosphate into 3’,5'-cyclic adenosine monophosphate and pyrophosphate. Adenylyl cyclases are grouped into six distinct Classes based on amino acid sequence similarity.
Holliday, Phillip
core
Ciliary adenylyl cyclases control the Hedgehog pathway [PDF]
, 2015 Protein kinase A (PKA) accumulates at the base of the cilium where it negatively regulates the Hedgehog (Hh) pathway. Although PKA activity is essentially controlled by the cAMP produced by adenylyl cyclases, the influence of these enzymes on the Hh ...
Herrera, Antonio +4 more
core +1 more source
Advanced Healthcare Materials, EarlyView.A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin +15 more
wiley +1 more source
Fungal Adenylyl Cyclase Acts As a Signal Sensor and Integrator and Plays a Central Role in Interaction with Bacteria [PDF]
, 2013 10.1371/journal.ppat.1003612PLoS ...
A Davis-Hanna +28 more
core +2 more sources
Annals of Gastroenterological Surgery, EarlyView.Blue LED irradiation targeted metabolic coupling between CAFs and colon cancer cells. Abstract Background The concepts examined in tumor metabolism research have been moving away from cancer cells themselves and the tumor microenvironment has become a focus of investigation.
Masaaki Nishi +8 more
wiley +1 more source