Results 51 to 60 of about 4,802 (96)

Obesity, White Adipose Tissue, and Adipokines Signaling in Male Reproduction

Molecular Nutrition &Food Research, EarlyView.
Role of adipokines in the hypothalamic‐pituitary‐gonadal axis (HPG) during obesity. Obesity induces structural and functional changes in WAT, with a consequent imbalance in the production and secretion of adipokines. While the adipokines adiponectin and omentin‐1 are downregulated, the adipokines leptin, resistin, vifastin, apelin, and chemerin are ...
Fabiane Ferreira Martins, Maria do Socorro Medeiros Amarante, Daiana Santana Oliveira, Isabela Macedo Lopes Vasques‐Monteiro, Vanessa Souza‐Mello, Julio Beltrame Daleprane, Christina da Silva Camillo   +6 more
wiley   +1 more source

ADENYLYL CYCLASE TYPE 9: REGULATION AND CARDIAC FUNCTION [PDF]

, 2018
Abnormalities in cardiac stress signaling underlie a number of cardiovascular diseases (e.g. arrhythmias and heart failure). Cardiac stress signaling pathways normally integrate signals from the sympathetic nervous system to promote efficient contraction
Baldwin, Tanya A., Baldwin, Tanya A.
core   +1 more source

Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum. [PDF]

, 2000
We report here that guanylyl cyclase activity is associated with two large integral membrane proteins (PfGCalpha and PfGCbeta) in the human malaria parasite Plasmodium falciparum.
Altschul, Bakalyar, Baker, Bilker, Brooks, Bzik, Cavalier-Smith, Chinkers, Cowman, Defer, Devereaux, Don, Garbers, Gilman, Harte, Ishikawa, Janssens, Jencks, Kawamoto, Koch, Krupinsky, Li, Li, Li, Linder, Liu, MacLennan, Nakane, Pitt, Ripmaster, Robson, Sambrook, Sanchez, Saul, Schulkes, Schultz, Schultz, Sunahara, Sunahara, Tang, Taylor, Tesmer, Thaithong, Toyofuku, Triglia, Triglia, Triglia, Tucker, van Es, Walliker, Ward, Zhang, Zimmerman   +52 more
core   +1 more source

Physiological Sensing of Carbon Dioxide/Bicarbonate/pH via Cyclic Nucleotide Signaling [PDF]

, 2011
Carbon dioxide (CO2) is produced by living organisms as a byproduct of metabolism. In physiological systems, CO2 is unequivocally linked with bicarbonate (HCO3−) and pH via a ubiquitous family of carbonic anhydrases, and numerous biological processes are
Acin-Perez, Acin-Perez, Baillie, Bajpai, Bauman, Beene, Berrera, Blitzer, Boatman, Breton, Bretscher, Brown, Buck, Bundey, Buxton, Cann, Carlson, Carnegie, Chaloupka, Chao, Chen, Chen, Creighton, Davare, DiPilato, Dodge, Duda, Efendiev, Esposito, Fan, Farrell, Flores, Fraser, Garbers, Garty, Geng, Geng, Gervasi, Gray, Gudis, Guo, Hall, Hallem, Hallem, Hess, Houslay, Hu, Ichikawa, Iyengar, Jaiswal, Jaiswal, Jiang, Jochen Buck, Johnson, Jones, Kamenetsky, Karpen, Kaupp, Kishida, Klengel, Kobayashi, Kumar, Lee, Levine, Li, Linder, Litvin, Lonny Levin, Maren, Maren, Marx, McSorley, Meyer-Franke, Mittag, Mogensen, Mongillo, Neill, Okamura, Pastor-Soler, Paulucci-Holthauzen, Paunescu, Paunescu, Pelligrino, Piggott, Ponsioen, Ramos, Raymond, Reed, Rich, Robison, Sayner, Sayner, Schmid, Schuh, Scott, Shelly, Sinclair, Steegborn, Stessin, Summers, Sun, Tash, Tasken, Terrin, Tesmer, Tresguerres, Tresguerres, Tresguerres, Tresguerres, Tresguerres, Tresguerres, Tresguerres, Visconti, Visconti, Visconti, Wang, Willoughby, Willoughby, Wu, Xie, Xie, Yanagimachi, Zaccolo, Zaccolo, Zippin, Zippin   +125 more
core   +3 more sources

Investigating the Mechanism of Conditioning Versus Postoperative Electrical Stimulation to Enhance Nerve Regeneration: One Therapy, Two Distinct Effects

Muscle &Nerve, EarlyView.
ABSTRACT Regeneration after peripheral nerve injury is often insufficient for functional recovery. Postoperative electrical stimulation (PES) following injury and repair significantly improves clinical outcomes; recently, conditioning electrical stimulation (CES), delivered before nerve injury, has been introduced as a candidate for clinical ...
Paige B. Hardy, Bonnie Y. Wang, K. Ming Chan, Christine A. Webber, Jenna‐Lynn B. Senger   +4 more
wiley   +1 more source

Pathways-driven Sparse Regression Identifies Pathways and Genes Associated with High-density Lipoprotein Cholesterol in Two Asian Cohorts [PDF]

arXiv, 2013
Standard approaches to analysing data in genome-wide association studies (GWAS) ignore any potential functional relationships between genetic markers. In contrast gene pathways analysis uses prior information on functional structure within the genome to identify pathways associated with a trait of interest. In a second step, important single nucleotide
arxiv  

Using a Robust and Sensitive GFP-Based cGMP Sensor for Real-Time Imaging in Intact Caenorhabditis elegans. [PDF]

, 2019
cGMP plays a role in sensory signaling and plasticity by regulating ion channels, phosphodiesterases, and kinases. Studies that primarily used genetic and biochemical tools suggest that cGMP is spatiotemporally regulated in multiple sensory modalities ...
Ali, Nebat, Andersen, Kristine, Barsi-Rhyne, Benjamin, Brueggemann, Chantal, Costa, Wagner Steuer, Ferkey, Denise M, Futey, Mary, Gottschalk, Alexander, Hamilton, O Scott, Hill, Tyler, Krzyzanowski, Michelle C, L'Etoile, Noelle, Li, Joy, Mitchell, Jordan, Nagpal, Jatin, Schneider, Martin W, Sengupta, Piali, Shankar, Raakhee, Tran, Alan, VanHoven, Miri, Varshney, Aruna, Woldemariam, Sarah, Yu, Yanxun V   +22 more
core  

High Adenylyl Cyclase Activity and \u3cem\u3eIn Vivo\u3c/em\u3e cAMP Fluctuations in Corals Suggest Central Physiological Role [PDF]

, 2013
Corals are an ecologically and evolutionarily significant group, providing the framework for coral reef biodiversity while representing one of the most basal of metazoan phyla. However, little is known about fundamental signaling pathways in corals. Here
Barott, Katie, Barron, Megan E, Buck, J., Haramaty, L., Helman, Y., Hess, K. C, Levin, L. R, Tresguerres, Martin   +7 more
core   +2 more sources

Development of a Heuristic Machine Analogy Method for Model Simplification With an Application to a Large‐Scale Model of Gi/Gs Signaling

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Model simplification is a process to simplify large‐scale mathematical models to enable easy applications such as simulation and parameter estimation. A novel heuristic machine analogy method of model simplification was developed and applied to a motivating example of a model for cAMP signaling switch induced by Gi/Gs pathway competition for ...
Liang Yang, David Finlay, Michelle Glass, Stephen Duffull   +3 more
wiley   +1 more source

The Enigmatic Canal-Associated Neurons Regulate Caenorhabditis elegans Larval Development Through a cAMP Signaling Pathway. [PDF]

, 2019
Caenorhabditis elegans larval development requires the function of the two Canal-Associated Neurons (CANs): killing the CANs by laser microsurgery or disrupting their development by mutating the gene ceh-10 results in early larval arrest. How these cells
Chien, Jason, Garriga, Gian, Grosche, Sarah, Mörck, Catarina, Wolf, Fred W, Yosef, Nebeyu   +5 more
core