Results 61 to 70 of about 4,802 (96)

Genetic and Pharmacological Inhibition of Metabotropic Glutamate Receptor Signalling Extends Lifespan in Drosophila

Aging Cell, EarlyView.
We show that genetic and pharmacological inhibition of the metabotropic glutamate receptor, DmGluRA extends Drosophila lifespan, improves stress tolerance and alters early‐life locomotion. Several markers indicative of reduced ribosomal biogenesis, a hallmark of longevity, were also detected in these flies.
Cui Guan, Abigail Otchere, Mihails Laskovs, Irene Papatheodorou, Cathy Slack   +4 more
wiley   +1 more source

Funktionelle Charakterisierung von Adenylatzyklasen der Honigbiene Apis mellifera [PDF]

, 2005
Adenylyl cyclases (ACs) are enzymes that synthesize the intracellular messenger adenosine 3',5'-cyclic monophosphate (cAMP). The physiological impact of ACs has been intensively investigated in the mammalian brain and in the fruitfly Drosophila ...
Wachten, Sebastian
core  

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, EarlyView.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source

A non‐hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation

Andrology, EarlyView.
Abstract Background and objectives Epididymal transit renders key competence to mammalian spermatozoa for fertilizing eggs. Generally, the two paralogs of glycogen synthase kinase 3, GSK3α and GSK3β, functionally overlap except in testis and sperm. We showed that GSK3α is essential for epididymal sperm maturation and fertilization.
Mustfa Kabi, Aditi Khamamkar, Kwaku Kyei‐Baffour, Michel Weïwer, Srinivasan Vijayaraghavan, Souvik Dey   +5 more
wiley   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source

Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase [PDF]

, 1990
Large deletion and small insertion mutations in the adenylyl cyclase gene of Saccharomyces cerevisiae were used to map regions required for activation by RAS protein in vitro.
Ballester, R., Chester, N., Colicelli, J., Field, J., Wigler, M. H., Young, D.   +5 more
core   +2 more sources

THE IDENTIFICATION OF NOVEL INORGANIC CARBON SENSITIVE ENZYMES [PDF]

, 2010
Adenylyl cyclase catalyses the formation of the second messenger adenosine-3’, 5’-monophosphate from adenosine triphosphate, and is involved in a number of diverse signalling pathways in eukaryotes and prokaryotes.
TOWNSEND, PHILIP,DAVID
core  

Trichomonas Transmembrane Cyclases Result from Massive Gene Duplication and Concomitant Development of Pseudogenes [PDF]

, 2010
Trichomonas vaginalis is the only medically important protist (single-cell eukaryote) that is sexually transmitted. The ∼160-Mb Trichomonas genome contains more predicted protein-encoding genes (∼60,000) than the human genome.
A Glasier, A Philip, A Scherf, AF Garcia, AG Gilman, B Van Der Pol, C Aurrecoechea, CG Clark, CG Prucca, CJ Noël, D Martin, D Pal, DA Baker, DB Smith, DL Beck, DL Swofford, DV Babushok, E Arner, EJ Pritham, Elodie Ghedin, ES Balakirev, F Ronquist, GE Crooks, H Ochman, HA Schmidt, J Cui, J Lu, JA Upcroft, JC Meade, JC Silva, JH Fong, JH Weber, Jike Cui, JM Carlton, John Samuelson, JP Demuth, JR Schwebke, K Hjort, K Lal, L Käll, L Marcello, LM Figueiredo, M Tibayrenc, MA Cooper, MN Davies, P Blume-Jensen, P Wiegn, PM Wolanin, PW Kreibel, Q Zhou, R Arroyo, RC Edgar, RP Hirt, S Vanácová, SA Sawyer, SB Malik, SF Altschul, SR Neves, Suchismita Das, T Crucitti, T Seebeck, Temple F. Smith, TM Wilkie, UC Alsmark, VJ Johnston, Z Zhang   +65 more
core   +5 more sources

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase [PDF]

, 2008
Background Soluble guanylate cyclases generate cyclic GMP when bound to nitric oxide, thereby linking nitric oxide levels to the control of processes such as vascular homeostasis and neurotransmission. The guanylate cyclase catalytic module, for which no
Derbyshire, Emily R, Kuriyan, John, Lamers, Meindert H, Marletta, Michael A, Winger, Jonathan A   +4 more
core   +3 more sources

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source