Results 61 to 70 of about 83,442 (296)
Soluble adenylyl cyclase in the eye
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014 Adenylyl cyclases (ACs) are a family of enzymes which convert ATP to cAMP, an essential intermediate in many signal transduction pathways. Of the 10 AC genes in man, 9 fall into the category of transmembrane ACs (tmACs), which associate with G-protein coupled receptors (GPCRs) and are activated by forskolin.
Alan D. Marmorstein +2 more
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Adenylyl cyclases 1 and 8 initiate a presynaptic homeostatic response to ethanol treatment. [PDF]
PLoS ONE, 2009 BACKGROUND:Although ethanol exerts widespread action in the brain, only recently has progress been made in understanding the specific events occurring at the synapse during ethanol exposure. Mice deficient in the calcium-stimulated adenylyl cyclases, AC1
Alana C Conti +6 more
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Soluble adenylyl cyclase: A novel player in cardiac hypertrophy induced by isoprenaline or pressure overload. [PDF]
PLoS ONE, 2018 In contrast to the membrane bound adenylyl cyclases, the soluble adenylyl cyclase (sAC) is activated by bicarbonate and divalent ions including calcium.
Ilona Schirmer +11 more
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Separate roles of PKA and EPAC in renal function unraveled by the optogenetic control of cAMP levels in vivo [PDF]
, 2013 Cyclic AMP (cAMP) is a ubiquitous second messenger that regulates a variety of essential processes in diverse cell types, functioning via cAMP-dependent effectors such as protein kinase A (PKA) and/or exchange proteins directly activated by cAMP (EPAC ...
Akbari +60 more
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Astrocytic Calcium and cAMP in Neurodegenerative Diseases
Frontiers in Cellular Neuroscience, 2022 It is commonly accepted that the role of astrocytes exceeds far beyond neuronal scaffold and energy supply. Their unique morphological and functional features have recently brough much attention as it became evident that they play a fundamental role in ...
Marta Sobolczyk, Tomasz Boczek
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Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase [PDF]
, 2012 Cilia of olfactory sensory neurons are the primary sensory organelles for olfaction. The detection of odorants by the main olfactory epithelium (MOE) depends on coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia.
Chen, Xuanmao +2 more
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Bicarbonate Stimulated Adenylyl Cyclases [PDF]
IUBMB Life, 2004 AbstractBicarbonate ion is fundamental to the biology of all living organisms. HCO3‐ is vital to such diverse physiological processes as carbon fixation, cellular homeostasis, sperm maturation, and nucleotide synthesis. A defined subset of adenylyl cyclases identified in eukaryotes and prokaryotes are directly activated by HCO3‐.
openaire +3 more sources
BMC Genomics, 2002 Background The CyaB protein from Aeromonas hydrophila has been shown to possess adenylyl cyclase activity. While orthologs of this enzyme have been found in some bacteria and archaea, it shows no detectable relationship to the classical nucleotide ...
Aravind L, Iyer Lakshminarayan M
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Cells, 2021 The vascular hypothesis used to explain the pathophysiology of Alzheimer’s disease (AD) suggests that a dysfunction of the cerebral microvasculature could be the beginning of alterations that ultimately leads to neuronal damage, and an abnormal increase ...
Dolores Viña +3 more
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sAC as a model for understanding the impact of endosymbiosis on cell signaling [PDF]
, 2014 As signaling pathways evolve, selection for new functions guides the co-option of existing material. Major transitions in the history of life, including the evolution of eukaryotes and multicellularity, exemplify this process.
Blackstone, Neil W.
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