Results 81 to 90 of about 83,442 (296)

Adenylyl Cyclase Localization Regulates Streaming during Chemotaxis [PDF]

, 2003
We studied the role of the adenylyl cyclase ACA in Dictyostelium discoideum chemotaxis and streaming. In this process, cells orient themselves in a head to tail fashion as they are migrating to form aggregates.
Barr, Valarie A., Kriebel, Paul W., Parent, Carole A.   +2 more
core   +1 more source

ADCY5‐Mosaic Variants: A Diagnosis Not to Be Missed

Movement Disorders Clinical Practice, EarlyView.
Abstract Background An increasing number of ADCY5‐mosaic patients, seemingly with a milder phenotype, are being identified. However, an in‐depth assessment of their clinical characteristics is lacking. Cases We collected and analyzed data from 12 consecutive ADCY5‐mosaic patients diagnosed at our center and 7 cases from the literature; 63% of the ...
Alice Innocenti, Emmanuel Roze, Florence Riant, Marie‐Céline François‐Heude, Bérénice Lecardonnel, Giacomo Garone, Maxime Colmard, Eline Chauvet‐Piat, Anne‐Cécile Chaux, Marie‐Aude Spitz, Beatrice Desnous, Catherine Sarret, Philippe Damier, Thomas Wirth, Mathieu Anheim, Emilie Retailleau, Estelle Conabady, Caroline Dubacq, Oriane Trouillard, Aurélie Méneret, Agathe Roubertie   +20 more
wiley   +1 more source

Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum. [PDF]

, 2000
We report here that guanylyl cyclase activity is associated with two large integral membrane proteins (PfGCalpha and PfGCbeta) in the human malaria parasite Plasmodium falciparum.
Altschul, Bakalyar, Baker, Bilker, Brooks, Bzik, Cavalier-Smith, Chinkers, Cowman, Defer, Devereaux, Don, Garbers, Gilman, Harte, Ishikawa, Janssens, Jencks, Kawamoto, Koch, Krupinsky, Li, Li, Li, Linder, Liu, MacLennan, Nakane, Pitt, Ripmaster, Robson, Sambrook, Sanchez, Saul, Schulkes, Schultz, Schultz, Sunahara, Sunahara, Tang, Taylor, Tesmer, Thaithong, Toyofuku, Triglia, Triglia, Triglia, Tucker, van Es, Walliker, Ward, Zhang, Zimmerman   +52 more
core   +1 more source

Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains.

Physiological Reviews, 2007
The adenylyl cyclases are variously regulated by G protein subunits, a number of serine/threonine and tyrosine protein kinases, and Ca(2+). In some physiological situations, this regulation can be readily incorporated into a hormonal cascade, controlling
D. Willoughby, D. Cooper
semanticscholar   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

A defined subset of adenylyl cyclases is regulated by bicarbonate ion [PDF]

, 2003
The molecular basis by which organisms detect and respond to fluctuations in inorganic carbon is not known. The cyaB1 gene of the cyanobacterium Anabaena sp.
Cann, M.J., Hammer, A., Kanacher, T., Zhou, J.   +3 more
core   +2 more sources

Adenylyl cyclases (ACs) in GtoPdb v.2023.1 [PDF]

, 2023
Adenylyl cyclase, E.C. 4.6.1.1, converts ATP to cyclic AMP and pyrophosphate. Mammalian membrane-delimited adenylyl cyclases (nomenclature as approved by the NC-IUPHAR Subcommittee on Adenylyl cyclases [11]) are typically made up of two clusters of six ...
Dessauer, Carmen W., Ostrom, Rennolds, Seifert, Roland, Watts, Val J.   +3 more
core   +2 more sources

Mutational analysis gives insight into substrate preferences of a nucleotidyl cyclase from Mycobacterium avium. [PDF]

PLoS ONE, 2014
Mutational, crystallographic and phylogenetic analysis of nucleotidyl cyclases have been used to understand how these enzymes discriminate between substrates.
Wajeed Syed, Melwin Colaςo, Sandra Misquith   +2 more
doaj   +1 more source

Stimulation of Mammalian G-protein-responsive Adenylyl Cyclases by Carbon Dioxide

Journal of Biological Chemistry, 2009
Carbon dioxide is fundamental to the physiology of all organisms. There is considerable interest in the precise molecular mechanisms that organisms use to directly sense CO2.
Philip D. Townsend, Phillip M. Holliday, Stepan Fenyk, K. Hess, M. Gray, David R. W. Hodgson, M. Cann   +6 more
semanticscholar   +1 more source

A non‐hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation

Andrology, EarlyView.
Abstract Background and objectives Epididymal transit renders key competence to mammalian spermatozoa for fertilizing eggs. Generally, the two paralogs of glycogen synthase kinase 3, GSK3α and GSK3β, functionally overlap except in testis and sperm. We showed that GSK3α is essential for epididymal sperm maturation and fertilization.
Mustfa Kabi, Aditi Khamamkar, Kwaku Kyei‐Baffour, Michel Weïwer, Srinivasan Vijayaraghavan, Souvik Dey   +5 more
wiley   +1 more source