Results 81 to 90 of about 4,802 (96)

Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk

Cell Proliferation, EarlyView.
This graphical abstract illustrates the reciprocal crosstalk between the brain and peripheral organs, highlighting the profound impact of exercise on brain health through systemic interactions. It underscores how exercise influences the brain via signals from various organs and, conversely, how the brain modulates functions of peripheral organs.
Shirin Pourteymour, Rakesh Kumar Majhi, Frode A. Norheim, Christian A. Drevon   +3 more
wiley   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, EarlyView.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

A PDE4 shortform degrader: a first in isoform‐specific PDE4 inhibition

The FEBS Journal, EarlyView.
Clinically used phosphodiesterase 4 (PDE4) inhibitors lack selectivity for PDE4 enzyme isoforms, which leads to documented side effects. Building in enzyme selectivity has proved difficult because all PDE4 enzymes share highly conserved catalytic domains. The report by Sin et al.
Donald H. Maurice
wiley   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source

Hypotheses in light detection by vertebrate ancient opsin in the bird brain

Journal of Neuroendocrinology, EarlyView.
Abstract Extra‐retinal photoreception is common across fish and avian species. In birds, the hypothalamus contains non‐visual photoreceptors that detect light and regulate multiple endocrine systems. To date, light‐dependent control of seasonal reproduction is one of the most well‐studied systems that require deep brain photoreception.
Tyler J. Stevenson, Timothy A. Liddle, Simone L. Meddle, Jonathan H. Pérez, Stuart N. Peirson, Russell G. Foster, Gaurav Majumdar   +6 more
wiley   +1 more source

FUNCTIONAL SELECTIVITY DOWNSTREAM OF Gαi/o-COUPLED RECEPTORS [PDF]

, 2015
G protein-coupled receptors (GPCRs) are drug targets that often activate multiple signaling pathways. The multiple GPCR responses provide opportunities for biased or functionally selective ligands to preferentially modulate one signaling pathway over ...
Brust Fernandes, Tarsis
core   +1 more source

Salivary Proteomics for Detecting Novel Biomarkers of Periodontitis: A Systematic Review

Journal of Periodontal Research, EarlyView.
Untargeted salivary proteomics identified promising biological molecules consistently over‐ or under‐expressed in periodontitis patients compared to periodontally healthy subjects, but further targeted approaches are required for their validation. ABSTRACT Aim Salivary content is regarded as a powerful diagnostic window for oral and systemic diseases ...
Matteo Corana, Giacomo Baima, Giovanni Iaderosa, Francesco Franco, Jianjian Zhang, Giovanni Nicolao Berta, Federica Romano, Mario Aimetti   +7 more
wiley   +1 more source

High voltage activated Ca2+ channel [PDF]

, 1993
A Cavalié, A Hui, A Mikami, A Röhrkasten, A Welling, A Welling, AE Lacerda, AM Brown, C Kleuss, C Mundina-Weilenmann, D Singer, E Bosse, E Bosse, E Perez-Reyes, E Perez-Reyes, E Perez-Reyes, E Rios, EI Rotman, F Hofmann, G Varadi, H Nakayama, HL Kim, HR Guy, HS Kim, IM Mintz, J Garcia, J Striessnig, J Striessnig, K Itagaki, K Nunoki, KS Jongh De, KS Jongh De, KS Jongh De, L Hymel, M Bertolino, M Biel, M Biel, M Kameyama, M Pragnell, ME Williams, ME Williams, P Lory, P Ruth, R Hullin, R Staudinger, RI Norman, RJ Diebold, RJ Miller, RS Kass, S Hamilton, S Regulla, S Seino, SB Ellis, SD Jay, SD Jay, SJ Dubel, T Schneider, T Tanabe, T Tanabe, T Tanabe, T Tanabe, TP Snutch, TP Snutch, TVB Starr, U Klöckner, V Flockerzi, W Trautwein, WJ Koch, X Wei, Y Lai, Y Mori   +70 more
core   +1 more source

Developmental regulation and evolution of cAMP signalling in Dictyostelium [PDF]

, 2007
Through evolution the social amoebas have developed mechanisms to adapt to environmental changes and ensure survival. This thesis explores the evolutionary origins of cAMP signalling and regulation of developmental decisions in the model organism ...
Alvarez-Curto, E.
core   +1 more source

Incretin hormones and obesity

The Journal of Physiology, EarlyView.
Abstract figure legend The incretin system in obesity. The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) (yellow) and glucagon‐like peptide‐1 (GLP‐1) (blue) are produced by the proximal and distal small intestinal epithelium, where they are released postprandially into the bloodstream to modulate a myriad of physiological and ...
Constanza Alcaino, Frank Reimann, Fiona M. Gribble   +2 more
wiley   +1 more source