Results 111 to 120 of about 53,252 (254)

Peptide RL‐QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β‐Catenin Axis

Exploration, EarlyView.
Amphibian‐derived peptide RL‐QN15 activates the Wnt/β‐catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing.
Yuansheng Li, Qiuye Jia, Naixin Liu, Saige Yin, Junyuan Wang, Yujing Ding, Yuliu Yang, Ying Peng, Zeqiong Ru, Shaoyang Zhang, Bu'er Qi, Jun Sun, Li He, Ying Wang, Kun Guo, Xinwang Yang   +15 more
wiley   +1 more source

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells

Journal of Inflammation, 2017
Background Wnt5A is released by activated macrophages and elevated levels have been detected in sepsis patients with severe systemic inflammation. However, the signalling and functional effects of Wnt5A in the vascular endothelial cells (VEC) remained ...
Tom Skaria, Esther Bachli, Gabriele Schoedon   +2 more
doaj   +1 more source

Fine structure of the intercalated disc and cardiac junctions in the black widow spider Latrodectus mactans

Applied Microscopy, 2020
Arthropods have an open circulatory system with a simple tubular heart, so it has been estimated that the contractile pumping structure of the cardiac muscle will be less efficient than that of vertebrates.
Yan Sun, Seung-Min Lee, Bon-Jin Ku, Myung-Jin Moon   +3 more
doaj   +1 more source

Evaluation of Discoidin domain receptor 1 (DDR1) in junctional epithelial permeability and wound healing

Journal of Periodontology, EarlyView.
Abstract Background Epithelium is the periodontal first line of defense against microbes. Discoidin domain receptor 1 (DDR1) is a collagen receptor expressed in epithelium. Ddr1 knockout (Ddr1−/−) mice develop periodontitis‐like defects, including junctional epithelium (JE) downgrowth, bacterial invasion, and alveolar bone loss.
Christina Zachariadou, Anuja Doshi, Dimitris N. Tatakis, Brian L. Foster   +3 more
wiley   +1 more source

Force transduction by cadherin adhesions in morphogenesis [version 1; peer review: 3 approved]

F1000Research, 2019
Mechanical forces drive the remodeling of tissues during morphogenesis. This relies on the transmission of forces between cells by cadherin-based adherens junctions, which couple the force-generating actomyosin cytoskeletons of neighboring cells ...
Willem-Jan Pannekoek, Johan de Rooij, Martijn Gloerich   +2 more
doaj   +1 more source

Insights into the molecular mechanism of Sjogren's syndrome [PDF]

, 2017
Sjogren’s syndrome (SS) is a chronic autoimmune disease, that affects primarily salivary and lacrimal glands, leading to increased morbidity. Recent studies indicate that loss of salivary gland function is associated with defective cell polarity ...
Langara, Hans A.
core  

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, EarlyView.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source

Correction to: Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-β–dependent vascular endothelial cadherin tyrosine phosphorylation

Cardiovascular Diabetology, 2017
This article was unintentionally published twice in this journal, by the same authors. The following should be considered the version of record and used for citation purposes: “Mehran Haidari, Wei Zhang, James T Willerson and Richard AF Dixon, Disruption
Mehran Haidari, Wei Zhang, James T. Willerson, Richard A. F. Dixon   +3 more
doaj   +1 more source

Molecular components of the adherens junction

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2008
Adherens junctions serve to couple individual cells into various arrangements required for tissue structure and function. The central structural components of adherens junctions are transmembrane adhesion receptors, and their associated actin-binding/regulatory proteins.
Niessen, Carien M., Gottardi, Cara J.
openaire   +2 more sources