Results 31 to 40 of about 53,252 (254)

Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension

Nature Communications, 2016
The stability of epithelial adherens junctions depends on tension generated by actomyosin contractility. Here Lee et al. describe a novel role for the axon guidance receptor Neogenin in maintaining junctional stability by recruiting actin nucleation ...
Natalie K. Lee, Ka Wai Fok, Amanda White, Nicole H. Wilson, Conor J. O’Leary, Hayley L. Cox, Magdalene Michael, Alpha S. Yap, Helen M. Cooper   +8 more
doaj   +1 more source

Gene mutations resulting in the development of ARVC/D could affect cardiac pacemaker and conductive tissue

Frontiers in Physiology, 2012
In contrast to epithelial cells, cardiomyocytes are connected by complex hybrid-type adhering junctions, termed composite junctions (areae compositae).
Sebastian ePieperhoff
doaj   +1 more source

Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2. [PDF]

PLoS ONE, 2012
The fibroblast growth factor (FGF) system plays a critical role in the maintenance of vascular integrity via enhancing the stability of VE-cadherin at adherens junctions. However, the precise molecular mechanism is not well understood.
Kunihiko Hatanaka, Anthony A Lanahan, Masahiro Murakami, Michael Simons   +3 more
doaj   +1 more source

β-Catenin is a pH sensor with decreased stability at higher intracellular pH. [PDF]

, 2018
β-Catenin functions as an adherens junction protein for cell-cell adhesion and as a signaling protein. β-catenin function is dependent on its stability, which is regulated by protein-protein interactions that stabilize β-catenin or target it for ...
Aberle, Baumgartner, Bree K. Grillo-Hill, Chairoungdua, Choi, Choi, Cold Spring Harbor Protocols, Dai, Daugherty, Denker, Denker, Diane L. Barber, Endo, Forbes, Forbes, Frantz, Frescas, Grillo-Hill, Ha, Hart, Ismahan Chire, Jobelle Peralta, Katharine A. White, Klaus, Krausova, Lee, Li, Liu, Liu, Mario Esquivel, Megy, Morin, Pai, Parks, Peifer, Peifer, Petherick, Pronobis, Reim, Reshkin, Sadot, Sahai-Hernandez, Schönichen, Sedgwick, Shafique, Simons, Stamos, Stehbens, Ulmschneider, Valenta, Vivian N. Bui, Waghmare, Webb, White, White, Wolff, Wu   +56 more
core   +1 more source

A New Perspective on Intercalated Disc Organization: Implications for Heart Disease

Dermatology Research and Practice, 2010
Adherens junctions and desmosomes are intercellular adhesive junctions and essential for the morphogenesis, differentiation, and maintenance of tissues that are subjected to high mechanical stress, including heart and skin.
Jifen Li, Glenn L. Radice
doaj   +1 more source

Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia

Neural Development, 2017
Background In developing tissues, cell polarity and tissue architecture play essential roles in the regulation of proliferation and differentiation. During cerebral cortical development, adherens junctions link highly polarized radial glial cells in a ...
Jennifer Rakotomamonjy, Molly Brunner, Christoph Jüschke, Keling Zang, Eric J. Huang, Louis F. Reichardt, Anjen Chenn   +6 more
doaj   +1 more source

Adherens, tight, and gap junctions in ependymal cells: A systematic review of their contribution to CSF-brain barrier

Frontiers in Neurology, 2023
IntroductionThe movement of fluids and solutes across the ependymal barrier, and their changes in physiologic and disease states are poorly understood.
Riccardo Serra, J. Marc Simard, J. Marc Simard, J. Marc Simard   +3 more
doaj   +1 more source

N-cadherin acts in concert with Slit1-Robo2 signaling in regulating aggregation of placode-derived cranial sensory neurons [PDF]

, 2009
Vertebrate cranial sensory ganglia have a dual origin from the neural crest and ectodermal placodes. In the largest of these, the trigeminal ganglion, Slit1-Robo2 signaling is essential for proper ganglion assembly.
Bronner-Fraser, Marianne, Shiau, Celia E.   +1 more
core   +2 more sources

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease [PDF]

, 2009
The events that convert adherent epithelial cells into individual migratory cells that can invade the extracellular matrix are known collectively as epithelial-mesenchymal transition (EMT).
Akitaya, Alkhateeb, Andersson, Barrallo-Gimeno, Bertocchini, Chea, Ciruna, del Barrio, Dixon, Dottori, el Ghouzzi, Favier, Gans, Garcia-Castro, Giehl, Haraguchi, Hervé Acloque, Iwano, Johansson, Kalluri, Katherine Fishwick, Kitajima, Kos, Kwok, Liu, Liu, M. Angela Nieto, Manzanares, Marianne Bronner-Fraser, Martin, Mathieu, Meghan S. Adams, Moreno-Bueno, Nakagawa, Nakaya, Nieto, Peinado, Perea-Gomez, Perez-Pomares, Pijnenborg, Popperl, Sato, Sela-Donenfeld, Sela-Donenfeld, Selleck, Shah, Skromne, Tanimizu, Thiery, Varlet   +49 more
core   +3 more sources

Adherens Junction Assembly [PDF]

, 2012
Classical cadherins are a family of transmembrane proteins that mediate cell-cell adhesion at adherens junctions. A complex chain of cis- and trans- interactions between cadherin ectodomains establishes a cadherin adhesive cluster. A principal adhesive interaction in such clusters is an exchange of β strands between the first extracellular cadherin ...
openaire   +2 more sources