Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. [PDF]
, 2018 Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains ...
Liu, Fu-Tong, Wan, Lei, Yang, Ri-Yao
core +2 more sources
Oncostatin M Modulation of Lipid Storage
Biology, 2015 Oncostatin M (OSM) is a cytokine belonging to the gp130 family, whose members serve pleiotropic functions. However, several actions of OSM are unique from those of other gp130 cytokines, and these actions may have critical roles in inflammatory ...
Carrie M. Elks, Jacqueline M. Stephens
doaj +1 more source
PexRAP inhibits PRDM16-mediated thermogenic gene expression [PDF]
, 2017 How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear.
Dean, John M +8 more
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Lifestyle intervention in individuals with impaired glucose regulation affects Caveolin-1 expression and DNA methylation [PDF]
, 2020 © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Aims: We investigated whether a lifestyle intervention could influence expression and DNA methylation of diabetes-related genes in patients with impaired ...
Adam, S. +9 more
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Chronic unpredictable stress regulates visceral adipocyte-mediated glucose metabolism and inflammatory circuits in male rats [PDF]
, 2014 Chronic psychological stress is a prominent risk factor involved in the pathogenesis of many complex diseases, including major depression, obesity, and type II diabetes.
Abel +53 more
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Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
Nature Communications, 2018 The epigenetic mechanisms regulating adipose tissue development are poorly understood. Here the authors show that reduction of H3K36 methylation in preadipocytes, both by H3.3K36M expression and depletion of H3K36 methyltransferase Nsd2, impairs ...
Lenan Zhuang +9 more
doaj +1 more source
The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms [PDF]
, 2015 Objectives: The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.
Clark, S. +10 more
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Adipocyte, 2017 Adipocytes were identified in human bone marrow more than a century ago, yet until recently little has been known about their origin, development, function or interactions with other cells in the bone marrow. Little functional significance has been attributed to these cells, a paradigm that still persists today. However, we now know that marrow adipose
Mark C, Horowitz +10 more
openaire +2 more sources
Thermal stress induces glycolytic beige fat formation via a myogenic state. [PDF]
, 2019 Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue.
A Jaworski +48 more
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PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. [PDF]
, 2019 (1) Background: Paraoxonase 2 (PON2) is a ubiquitously expressed protein localized to endoplasmic reticulum and mitochondria. Previous studies have shown that PON2 exhibits anti-oxidant and anti-inflammatory functions, and PON2-deficient (PON2-def) mice ...
Fogelman, Alan M +9 more
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