Results 31 to 40 of about 282,105 (396)
Nature Communications, 2019 During wound healing in adult mouse skin, hair follicles and then adipocytes regenerate. Adipocytes regenerate from myofibroblasts, a specialized contractile wound fibroblast. Here we study wound fibroblast diversity using single-cell RNA-sequencing.
C. Guerrero-Juarez +14 more
semanticscholar +1 more source
Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics.
Biochemical Journal, 2020 Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD) organelles by professional storage cells called adipocytes.
Alexander Yang, E. Mottillo
semanticscholar +1 more source
Oncostatin M Modulation of Lipid Storage
Biology, 2015 Oncostatin M (OSM) is a cytokine belonging to the gp130 family, whose members serve pleiotropic functions. However, several actions of OSM are unique from those of other gp130 cytokines, and these actions may have critical roles in inflammatory ...
Carrie M. Elks, Jacqueline M. Stephens
doaj +1 more source
Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. [PDF]
, 2018 Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains ...
Liu, Fu-Tong, Wan, Lei, Yang, Ri-Yao
core +2 more sources
Thermal stress induces glycolytic beige fat formation via a myogenic state. [PDF]
, 2019 Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue.
A Jaworski +48 more
core +2 more sources
Journal of Clinical Investigation, 2019 Persistent, unresolved inflammation in adipose tissue is a major contributor to obesity-associated metabolic complications. However, the molecular links between lipid-overloaded adipocytes and inflammatory immune cells in obese adipose tissues remain ...
Yong Pan +8 more
semanticscholar +1 more source
Undernutrition and stage of gestation influence fetal adipose tissue gene expression [PDF]
, 2015 Funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS), including the Strategic Partnership for Animal Science Excellence (SPASE) and the U.S. National Institutes of Health (HD045784).
Adam, Clare L +7 more
core +1 more source
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.
Genes & Development, 1994 Previously, we have isolated and characterized an enhancer from the 5'-flanking region of the adipocyte P2 (aP2) gene that directs high-level adipocyte-specific gene expression in both cultured cells and transgenic mice.
P. Tontonoz +4 more
semanticscholar +1 more source
TGF-β/SMAD signaling regulation of mesenchymal stem cells in adipocyte commitment
Stem cell research & therapeutics, 2020 Adipocytes arising from mesenchymal stem cells (MSCs) requires MSC adipocyte commitment and differentiation of preadipocytes to mature adipocytes. Several signaling and some cytokines affect the adipogenesis of MSCs.
Sheng-Nan Li, Jia-fa Wu
semanticscholar +1 more source
Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function
Nature Communications, 2018 The epigenetic mechanisms regulating adipose tissue development are poorly understood. Here the authors show that reduction of H3K36 methylation in preadipocytes, both by H3.3K36M expression and depletion of H3K36 methyltransferase Nsd2, impairs ...
Lenan Zhuang +9 more
doaj +1 more source