Results 31 to 40 of about 171,177 (219)
International Journal of Molecular Sciences, 2018 Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and degraded bone microstructure, which leads to increased bone fragility and risks of bone fracture. Osteoporosis is generally age related and has become a major disease
Lifang Hu +5 more
semanticscholar +1 more source
Numerical analysis of a mechanotransduction dynamical model reveals homoclinic bifurcations of extracellular matrix mediated oscillations of the mesenchymal stem cell fate [PDF]
International Journal of Non-Linear Mechanics, 113, 146-157, 2019, 2019 We perform one and two-parameter numerical bifurcation analysis of a mechanotransduction model approximating the dynamics of mesenchymal stem cell differentiation into neurons, adipocytes, myocytes and osteoblasts. For our analysis, we use as bifurcation parameters the stiffness of the extracellular matrix and parameters linked with the positive ...
arxiv +1 more source
Adipocyte and lipid metabolism in cancer drug resistance.
Journal of Clinical Investigation, 2019 Development of novel and effective therapeutics for treating various cancers is probably the most congested and challenging enterprise of pharmaceutical companies.
Yihai Cao
semanticscholar +1 more source
BiologyThe growing obesity epidemic necessitates increased research on adipocyte and adipose tissue function and disease mechanisms that progress obesity. Historically, adipocytes were viewed simply as storage for excess energy. However, recent studies have demonstrated that adipocytes play a critical role in whole-body homeostasis, are involved in cell ...
Sean P. Blade +4 more
openaire +3 more sources
Computational modeling of the physical features that influence breast cancer invasion into adipose tissue [PDF]
APL Bioengineering 8 (2024) 036104Breast cancer invasion into adipose tissue strongly influences disease progression and metastasis. The degree of cancer cell invasion into adipose tissue depends on numerous biochemical and physical properties of cancer cells, adipocytes, and other key components of adipose tissue.
arxiv +1 more source
Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue.
Journal of Clinical Investigation, 2019 Brown adipose tissue (BAT), as the main site of adaptive thermogenesis, exerts beneficial metabolic effects on obesity and insulin resistance. BAT has been previously assumed to contain a homogeneous population of brown adipocytes.
Anying Song +19 more
semanticscholar +1 more source
Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin.
Circulation, 1999 BACKGROUND Among the many adipocyte-derived endocrine factors, we recently found an adipocyte-specific secretory protein, adiponectin, which was decreased in obesity.
N. Ouchi +12 more
semanticscholar +1 more source
bioRxiv, 2019 Immune cells are vital constituents of the adipose microenvironment that influence both local and systemic lipid metabolism. Mice lacking IL10 have enhanced thermogenesis, but the roles of specific cell types in the metabolic response to IL10 remain to ...
P. Rajbhandari +15 more
semanticscholar +1 more source
The potential roles of transacylation in intracellular lipolysis and related QSSA approximations [PDF]
arXiv, 2022 Fatty acids (FAs) are crucial energy metabolites, signalling molecules, and membrane building blocks for a wide range of organisms. Adipose triglyceride lipase (ATGL) is the first and presumingly most crucial regulator of FA release from triacylglycerols (TGs) stored within cytosolic lipid droplets.
arxiv
Cancer & Metabolism, 2017 BackgroundObesity is associated with increased recurrence and reduced survival of breast cancer. Adipocytes constitute a significant component of breast tissue, yet their role in provisioning metabolic substrates to support breast cancer progression is ...
Seher Balaban +12 more
semanticscholar +1 more source