Results 111 to 120 of about 39,170 (208)

Brown adipocytes from induced pluripotent stem cells-how far have we come? [PDF]

, 2020
A global increase in the number of individuals who are either overweight or obese is leading to a higher incidence of type 2 diabetes (T2D). Behavioral interventions for the treatment of obesity have yet to deliver desired outcomes, thus introducing a ...
Brown, Aaron C
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NR2F6 is essential for brown adipocyte differentiation and systemic metabolic homeostasis

Molecular Metabolism
Objective: Brown adipose tissue (BAT) development and function are essential for maintaining energy balance. However, the key factors that specifically regulate brown adipogenesis require further identification.
Wei-yu Zhou, Pei Liu, Yi-fan Xia, Yi-jie Shi, Hong-yu Xu, Meng Ding, Qi-qi Yang, Shu-wen Qian, Yan Tang, Yan Lu, Qi-qun Tang, Yang Liu   +11 more
doaj   +1 more source

Ultrastructure of brown adipocytes mitochondria in cell culture from explants [PDF]

, 1986
Brown adipocytes lose in culture their typical mitochondria, which are replaced by others of non typical morphology. During studies aimed at clarifying this phenomenon we found that better preservation of the 'typical' mitochondrial morphology is ...
Zancanaro C., Sbarbati A, Cigolini M., Cinti S., Sbarbati A., CINTI, Saverio, Cigolini M   +6 more
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An siRNA-based method for efficient silencing of gene expression in mature brown adipocytes [PDF]

, 2016
Brown adipose tissue is a promising therapeutic target for opposing obesity, glucose intolerance and insulin resistance. The ability to modulate gene expression in mature brown adipocytes is important to understand brown adipocyte function and delineate ...
Basse, Astrid Linde, Nedergaard, Jan,, Winther, Sally, Petersen, Marie Christine Helby, Isidor, Marie Sophie, Basse, Astrid L., Cannon, Barbara,, Isidor, Marie S., Cannon, Barbara, Nedergaard, Jan, Hansen, Jacob B., Petersen, M. Christine H.   +11 more
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Direct conversion of human fibroblasts to brown adipocytes by small chemical compounds

Scientific Reports, 2017
Brown adipocytes play an important role in human energy metabolism and prevention of obesity and diabetes. Induced pluripotent stem cells (iPSCs) represent a promising source for brown adipocytes; however, exogenous gene induction is generally required ...
Yukimasa Takeda, Yoshinori Harada, Toshikazu Yoshikawa, Ping Dai   +3 more
doaj   +1 more source

Brown and brite adipocytes: Same function, but different origin and response [PDF]

, 2017
Inducing brown adipocytes in white adipose tissues is a promising target to combat obesity and its related disorders in human beings. This goal has been especially encouraged by new important discoveries of human brown adipose tissues.
Chu, Dinh Toi
core   +1 more source

Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes

Cell Reports, 2017
White adipocytes are specialized for energy storage, whereas brown adipocytes are specialized for energy expenditure. Explicating this difference can help identify therapeutic targets for obesity.
Alfred K. Ramirez, Matthew D. Lynes, Farnaz Shamsi, Ruidan Xue, Yu-Hua Tseng, C. Ronald Kahn, Simon Kasif, Jonathan M. Dreyfuss   +7 more
doaj   +1 more source

Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis

Molecular Metabolism, 2018
Objective: Crosstalk between adipocytes and local neurons may be an important regulatory mechanism to control energy homeostasis. We previously reported that perturbation of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN ...
Adilson Guilherme, David J. Pedersen, Felipe Henriques, Alexander H. Bedard, Elizabeth Henchey, Mark Kelly, Donald A. Morgan, Kamal Rahmouni, Michael P. Czech   +8 more
doaj   +1 more source

Regulation of Intracellular Calcium in Brown Adipocytes [PDF]

, 1999
Intracellular Ca2+ is considered a primary regulator of cell function. In the present study, the control and the effects of intracellular Ca2+ in brown adipocytes have been investigated.
Wang, Lawrence C.H,, Zhang, Shi-Jin,
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Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages [PDF]

, 2007
Attainment of a brown adipocyte cell phenotype in white adipocytes, with their abundant mitochondria and increased energy expenditure potential, is a legitimate strategy for combating obesity.
Nedergaard, Jan,, Hamilton, D. Lee, Gimeno, RE, Petrovic, Natasa,, Hamilton, DL, Timmons, James A., Hamilton, D Lee, Wahlestedt, Claes, Timmons, JA, Larsson, Ola, Wahlestedt, C, Walden, Tomas B., Petrovic, N, Timmons, James A, Walden, Tomas B,, Lassmann, T, Lassmann, Timo, Wennmalm, Kristian, Walden, TB, Gimeno, Ruth E, Baar, Keith, Baar, K, Nedergaard, Jan, Gimeno, Ruth E., Wennmalm, K,, Hamilton, David Lee, Cannon, Barbara,, Walden, Tomas B, Petrovic, Natasa, Cannon, Barbara, Larsson, O,   +30 more
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