Results 191 to 200 of about 62,660 (267)

Interplay of Ser273 Phosphorylation and K268 and K293 Acetylation in PPARγ: Implications for PPARγ Activation

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 9, Page 1597-1609, September 2026.
ABSTRACT Post‐translational modifications (PTMs) play a critical role in regulating the transcriptional activity of PPARγ, a nuclear receptor central to glucose and lipid homeostasis. Among these, lysine acetylation at K268 and K293 and phosphorylation at S273 are particularly relevant to insulin sensitivity.
Caique Camargo Malospirito, Marieli Mariano Gonçalves Dias, Gabriel Ernesto Jara, Thayná Mendonça Avelino, Giovanna Blazutti Elias, Paulo Sergio Lopes de Oliveira, Ana Carolina Migliorini Figueira   +6 more
wiley   +1 more source

Perspectives on human adipose tissue: from cellular mechanisms to clinical complications. [PDF]

Diabetologia
Rydén M.
europepmc   +1 more source

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Clinical Endocrinology, Volume 105, Issue 3, Page 271-284, September 2026.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou   +5 more
wiley   +1 more source

Burn-associated metabolic dysfunction: could extracellular vesicles play a role? [PDF]

Clin Sci (Lond)
Farahat M, DadashiZadeh G, Ricciuti Z, Pappas A, Jeschke MG.   +4 more
europepmc   +1 more source

Diagnosis and management of equine metabolic syndrome

Equine Veterinary Education, Volume 38, Issue 9, Page 471-480, September 2026.
Summary Equine metabolic syndrome (EMS) is a prevalent endocrine disorder that increases the risk of hyperinsulinaemia‐associated laminitis (HAL), the most common and clinically significant form of laminitis. The central pathological feature of EMS is insulin dysregulation (ID), which encompasses basal or postprandial hyperinsulinaemia and tissue ...
F. R. Bertin
wiley   +1 more source

Clock Modulation by Naringenin Suppresses Lipogenesis and Promotes Adipose Tissue Browning. [PDF]

J Cell Physiol
Xiong X, Pangemanan J, Kiperman T, Sun Z, Paul A, Yechoor V, Ma K.   +6 more
europepmc   +1 more source

Intranasal Administration of Isoeugenol Improves Memory Deficits in APP/PS1 Old Mice—A Role Beyond Nrf2 Activation?

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Inactivation of the Nrf2/Are pathway in AD leads to decreased antioxidant and anti‐inflammatory response and to the accumulation of beta‐amyloid (Aβ) plaques, resulting in cognitive failure. Treatment with Isoeugenol activates Nrf2, reversing these outcomes by promoting antioxidant response in neuronal cells (N2a) and by increasing the anti ...
Ana Silva, Sónia Silva, Jéssica Macedo, Patrícia Moreira, Diana Baptista, Joana Bicker, Ana Fortuna, Joana Liberal, Beatriz Rodrigues, Rosa Resende, Inês Vitorino, Armanda E. Santos, Bruno Miguel Neves, Cláudia Pereira, Maria Teresa Cruz   +14 more
wiley   +1 more source

miR-10b-5p regulates adipocyte lineage commitment and adipogenesis via targeting of Gata6 and Tubby. [PDF]

Cell Commun Signal
Kalenderoglou N, Dimitri F, González CN, Vidal-Puig A, Hobbs J, Younis A, Christodoulides C, Carobbio S, Christian M.   +8 more
europepmc   +1 more source

Adaptation of White Adipocytes to Cooler Temperatures: Impacts on Energy Metabolism and Protein Acetylation

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Cultured white adipocytes exposed to 31°C undergo cell‐autonomous metabolic adaptation characterized by enhanced mitochondrial function and widespread remodeling of the mitochondrial acetylome. Acetyl‐proteomic and metabolomic profiling identified mitochondria‐associated proteins, including SHMT2 and PCCA, whose acetylation changes were linked to ...
Hiroyuki Mori, Hadla Hariri, William Moe, Sophia Durham, Yuridia Guzman, Emma Paulsson, Rachel C. Simmermon, Parth B. Bhanderi, Sydney K. Peterson, Mia J. Dickson, Charles R. Evans, Ormond A. MacDougald   +11 more
wiley   +1 more source

Fueling or Fighting Cancer? The Thermogenic Paradox of Brown Adipose Tissue. [PDF]

Curr Obes Rep
Guerrero JJG, Encarnacion PC, Wang CH, Del Rosario MAS, Notarte KI, Zhou J, Hsieh YT, Wang WY, Chang CW, Li WC.   +9 more
europepmc   +1 more source