Results 91 to 100 of about 352,221 (407)

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4. Methods We evaluated the clinical phenotype and muscle imaging, and performed a genetic workup that included exome sequencing, muscle RNAseq, and long‐read genome ...
Laura Llansó, Igor Stevanovski, Germán Morís, Roger Collet‐Vidiella, Alba Segarra‐Casas, Lidia González‐Quereda, Benjamín Rodríguez‐Santiago, Pia Gallano, Rodrigo Alvarez, Ana Vesperinas, Rosa Blanco, Beatriz San‐Millán, Carmen Navarro, Isabel Illa, Gianina Ravenscroft, Ira W. Deveson, Eduard Gallardo, Montse Olivé   +17 more
wiley   +1 more source

GALNT2 as a novel modulator of adipogenesis and adipocyte insulin signaling [PDF]

, 2019
Background/objectives: A better understanding of adipose tissue biology is crucial to tackle insulin resistance and eventually coronary heart disease and diabetes, leading causes of morbidity and mortality worldwide.
Antonucci, A., De Bonis, Maria Caterina, Di Paola, R., Mangiacotti, D., Marucci, A., Scarale, M. G., Trischitta, V.   +6 more
core   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

Topographical variation in lipid content and morphological structure of the blubber in the striped dolphin

Scientia Marina, 2015
We investigate stratification patterns and topographical variations in the blubber of the striped dolphin (Stenella coeruleoalba) to gain insights into its regionally-specific functions.
Encarna Gómez-Campos, Asunción Borrell, Jordi Correas, Alex Aguilar   +3 more
doaj   +1 more source

The Dual Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Atherosclerosis

Frontiers in Cardiovascular Medicine, 2021
Low-density lipoprotein receptor–related protein-1 (LRP1) is a large endocytic and signaling receptor belonging to the LDL receptor (LDLR) gene family and that is widely expressed in several tissues.
Jiefang Chen, Ying Su, Shulan Pi, Bo Hu, Ling Mao   +4 more
doaj   +1 more source

Chronic unpredictable stress regulates visceral adipocyte-mediated glucose metabolism and inflammatory circuits in male rats [PDF]

, 2014
Chronic psychological stress is a prominent risk factor involved in the pathogenesis of many complex diseases, including major depression, obesity, and type II diabetes.
Abel, Adler, Ahima, Archuleta, Barsy, Bartness, Bartolomucci, Bartolomucci, Bjorntorp, Bose, Bost, Bradesi, Bray, Buren, Cai, Christiansen, Depke, Despres, Desreumaux, Edgar, Fortuno, Gonnissen, Griffin, Hawley, Hennings, Hirosumi, Hotamisligil, Hotamisligil, Hotamisligil, Karagiannides, Karagiannides, Kim, Kyrou, Lamounier-Zepter, Lehrke, Ma, Marra, Morino, Nieuwenhuizen, Ogden, Pechlivanova, Perrini, Razzouk, Rodriguez, Shively, Slentz, Speaker, Stubbs, Tanti, van Reedt Dortland, Willner, Yu, Yuan, Zhang   +53 more
core   +1 more source

Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer

Cell Death and Disease, 2017
Obesity has been associated with increased incidence and mortality of a wide variety of human cancers including colorectal cancer. However, the molecular mechanism by which adipocytes regulate the metabolism of colon cancer cells remains elusive. In this
Yang-an Wen, X. Xing, Jennifer W Harris, Yekaterina Y. Zaytseva, Mihail I Mitov, D. Napier, H. Weiss, B. Mark Evers, Tianyan Gao   +8 more
semanticscholar   +1 more source

Adipokines and Associations with Incident Osteoporotic Fracture in Patients with Rheumatoid Arthritis

Arthritis Care &Research, Accepted Article.
Purpose We assessed whether circulating adipokines are associated with incident fractures in patients with rheumatoid arthritis (RA). Methods Three adipokines (adiponectin, leptin, fibroblast growth factor [FGF]‐21) were measured using banked enrollment serum from participants in a longitudinal RA cohort.
Joshua F. Baker, Bryant R. England, Michael D. George, Hannah Brubeck, Brian Sauer, Aleksander Lenert, Punyasha Roul, Geoffrey M. Thiele, Ted R. Mikuls, Katherine D. Wysham   +9 more
wiley   +1 more source

Insulin Regulates Lipolysis and Fat Mass by Upregulating Growth/Differentiation Factor 3 in Adipose Tissue Macrophages [PDF]

, 2019
学位記番号 ...
Bu, Yun, ブ, イュン, 歩, 云
core