Results 121 to 130 of about 160,546 (318)
Advanced Science, EarlyView.LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao +7 more
wiley +1 more source
International Journal of Cancer, Volume 152, Issue 5, Page 1025-1035, 1 March 2023., 2023 What's new? While early diagnosis of triple‐negative breast cancer (TNBC) is associated with heightened responsiveness to chemotherapy, biomarkers that can be detected noninvasively are needed to support early TNBC diagnosis. Our study suggests that such markers may exist in the form of methylation signatures in cell‐free DNA. Evaluation of methylation
Mehdi Manoochehri +13 more
wiley +1 more source
FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity
Advanced Science, EarlyView.Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li +11 more
wiley +1 more source
Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection
Advanced Science, EarlyView.The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng +10 more
wiley +1 more source
Promotion of human adipocyte precursor replication by 17beta-estradiol in culture. [PDF]
, 1978 Daniel A. K. Roncari, R L Van
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CeiTEA: Adaptive Hierarchy of Single Cells with Topological Entropy
Advanced Science, EarlyView.CeiTEA, a novel hierarchical clustering algorithm based on topological entropy, effectively captures complex structures underlying data. By constructing an adaptive multi‐nary partition tree, CeiTEA reveals hierarchical structures and local diversifications, outperforming existing methods in clustering accuracy and consistency and providing the ...
Bowen Tan +3 more
wiley +1 more source
Human adipocyte cholesterol. Concentration, localization, synthesis, and turnover. [PDF]
, 1975 Paul H. Schreibman, Ralph B. Dell
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Stimulation of glucose transport in rat adipocytes by insulin, adenosine, nicotinic acid and hydrogen peroxide. Role of adenosine 3′:5′-cyclic monophosphate [PDF]
, 1979 Wayne M. Taylor, Mitchell L. Halperin
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Genomic Evaluation of Recombination in Small Highly Inbred Beef Cattle Populations
Animal Research and One Health, EarlyView.The study characterizes recombination in small beef cattle populations, revealing higher rates in CGC composites compared to inbred Line 1 Herefords. It identifies significant SNP associations linked to recombination across various autosomes, highlighting complex polygenic influences, with implications for genetic diversity and breeding strategies ...
E. Hay, A. S. Ling
wiley +1 more source
Metabolomic analysis reveals the molecular mechanism related to leg abnormality in broilers
Animal Research and One Health, EarlyView.The graphical abstract shows the principal results of this study. Compared to the leg normal broilers, the serum calcium to phosphorus ratio was extremely decreased in the group with deformed leg bones. Additionally, a total of nine differential metabolites significantly associated with leg abnormalities and serum calcium and phosphorus levels were ...
Jumei Zheng +9 more
wiley +1 more source