Results 11 to 20 of about 1,754 (193)

Adipophilin distribution and colocalisation with lipid droplets in skeletal muscle [PDF]

Histochemistry and Cell Biology, 2009
Intramyocellular lipids (IMCL) are stored as discrete lipid droplets which are associated with a number of proteins. The lipid droplet-associated protein adipophilin (the human orthologue of adipose differentiation-related protein) is ubiquitously expressed and is one of the predominant lipid droplet-proteins in skeletal muscle.
Shaw, Christopher, Sherlock, Mark, Stewart, Paul M, Wagenmakers, Anton J. M   +3 more
core   +6 more sources

Die Regulation der Adipophilin-Expression [PDF]

, 2005
Adipophilin ist ein Protein des zellulären Lipid-Stoffwechsels. Es ist an Transport und Lagerung von Lipiden in der Zelle beteiligt. Adipophilin ist möglicherweise durch Schaumzellbildung an der Entstehung der Arteriosklerose beteiligt. Es wurde an THP1-Makrophagen untersucht, welche Transkriptionsfaktoren die Expression von Adipophilin-mRNA regulieren.
Eisenberg, M. (Monika)
core   +4 more sources

Lipid droplet targeting domains of adipophilin [PDF]

Journal of Lipid Research, 2003
Adipophilin (ADPH), a prominent protein component of lipid storage droplets (LSDs), is postulated to be necessary for the formation and cellular function of these structures.
James L. McManaman, William Zabaronick, Jerome Schaack, David J. Orlicky   +3 more
doaj   +3 more sources

Lipid droplet accumulation and adipophilin expression in follicular thyroid carcinoma

Biochemical and Biophysical Research Communications, 2023
Follicular neoplasms of the thyroid include follicular thyroid carcinoma (FTC) and follicular thyroid adenoma (FTA). However, the differences in cytological findings between FTC and FTA remain undetermined. Here, we aimed to evaluate the accumulation of lipid droplets (LDs) and the expression of adipophilin (perilipin 2/ADRP/ADFP), a known LD marker ...
Michiyo Hayakawa, J. Nicholas Taylor, Ryuta Nakao, Kentaro Mochizuki, Yuki Sawai, Kosuke Hashimoto, Koji Tabata, Yasuaki Kumamoto, Katsumasa Fujita, Eiichi Konishi, Shigeru Hirano, Hideo Tanaka, Tamiki Komatsuzaki, Yoshinori Harada   +13 more
openaire   +4 more sources

Perilipin and adipophilin expression in lipid loaded macrophages

Biochemical and Biophysical Research Communications, 2007
Lipid-filled macrophages (foam cells) are a defining feature of atherosclerotic plaques. Foam cells contain lipid droplet-associated proteins that in other cell types regulate lipid turnover. In foam cell such proteins may directly affect lipid droplet formation and lipid efflux.
Jenny, Persson, Eva, Degerman, Jan, Nilsson, Marie W, Lindholm   +3 more
openaire   +3 more sources

Adipophilin protein expression in muscle – a possible protective role against insulin resistance

The FEBS Journal, 2010
Adipophilin is a 50 kDa protein that belongs to the PAT family (perilipin, adipophilin, TIP47, S3‐12 and OXPAT), which comprises proteins involved in the coating of lipid droplets. Little is known about the functional role of adipophilin in muscle. Using the C2C12 cell line as a model, we demonstrate that palmitic acid‐treated cells highly express the ...
de Wilde, J., Smit, E., Snepvangers, F.J.M., de Wit, N.J.W., Mohren, R., Hulshof, M.F.M., Mariman, E.C.M.   +6 more
core   +5 more sources

Mammary glands of adipophilin-null mice produce an amino-terminally truncated form of adipophilin that mediates milk lipid droplet formation and secretion [PDF]

Journal of Lipid Research, 2008
Adipophilin (ADPH), a member of the perilipin family of lipid droplet-associated proteins, is hypothesized to mediate milk lipid formation and secretion.
Tanya D. Russell, Carol A. Palmer, David J. Orlicky, Elise S. Bales, Benny Hung-Junn Chang, Lawrence Chan, James L. McManaman   +6 more
doaj   +3 more sources

Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets [PDF]

BMC Biology, 2010
Background Spartin protein is involved in degradation of epidermal growth factor receptor and turnover of lipid droplets and a lack of expression of this protein is responsible for hereditary spastic paraplegia type 20 (SPG20).
Shekhtman Alexander, Loring Zak, Puttamadappa Swamy S, Hooper Christopher, Bakowska Joanna C   +4 more
doaj   +2 more sources

Adipophilin-stained lipid droplets and M2 macrophages in Jorge Lobo’s disease

International Journal of Infectious Diseases
Objectives: Jorge Lobo’s disease (JLd), a cutaneous mycosis caused by the fungus Paracoccidioides lobogeorgii, follows a chronic course and is refractory to any treatment modality.
Bruna Morassi Sasso, Andrelou Fralete Ayres Vallarelli, Patricia Sammarco Rosa, Andrea De Faria Fernandes Belone, Paulo Eduardo Neves Ferreira Velho, Maria Leticia Cintra, Eliane Maria Ingrid Amstalden   +6 more
doaj   +3 more sources

Metabolic Heterogeneity Confers Differences in the Tumor Microenvironment of Aggressive Types of Melanomas. [PDF]

J Oral Pathol Med
ABSTRACT Background Melanoma affects skin and mucosa and can be particularly aggressive when the lesion is an advanced cutaneous tumor or located in the sinonasal or oral mucosa. Reprogramming of energy metabolism has been defined as a hallmark of cancer; so this study aimed to verify the expression of proteins related to metabolism and cellular ...
de Souza do Nascimento J, Scarini JF, Egal ESA, Corrêa MB, Dos Reis RRD, Amorim LS, Robim RMM, Pinto CAL, Peresi PM, Francisco ALN, Fonseca FP, Kowalski LP, Carlos R, Mariano FV, Altemani A.   +14 more
europepmc   +2 more sources