Results 31 to 40 of about 1,754 (193)

S3-12, Adipophilin, and TIP47 Package Lipid in Adipocytes [PDF]

Journal of Biological Chemistry, 2005
Animals have evolved mechanisms to maintain circulating nutrient levels when energy demands exceed feeding opportunities. Mammals store most of their energy as triacylglycerol in the perilipin-coated lipid droplets of adipocytes. How newly synthesized triacylglycerol is delivered to perilipin-coated lipid droplets is poorly understood.
Nathan E, Wolins, Benjamin K, Quaynor, James R, Skinner, Marissa J, Schoenfish, Anatoly, Tzekov, Perry E, Bickel   +5 more
openaire   +2 more sources

Adipocyte differentiation-related protein reduces the lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnovers⃞

Journal of Lipid Research, 2007
Although neutral lipid storage droplets are ubiquitous in eukaryotic cells, very little is known about how their synthesis and turnover are controlled. Adipocyte differentiation-related protein (ADRP; also known as adipophilin) is found on the surface of
Laura L. Listenberger, Anne G. Ostermeyer-Fay, Elysa B. Goldberg, William J. Brown, Deborah A. Brown   +4 more
doaj   +1 more source

Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins

Journal of Lipid Research, 2010
The PAT family of proteins has been identified in eukaryotic species as diverse as vertebrates, insects, and amebazoa. These proteins share a highly conserved sequence organization and avidity for the surfaces of intracellular, neutral lipid storage ...
Alan R. Kimmel, Dawn L. Brasaemle, Monica McAndrews-Hill, Carole Sztalryd, Constantine Londos   +4 more
doaj   +1 more source

Effect of antioxidant treatment with n-acetylcysteine and swimming on lipid expression of sebaceous glands in diabetic mice

Scientific Reports, 2021
The sebaceous gland (SG) is involved in different inflammatory, infectious and neoplastic processes of the skin and can be related to specific diseases, e.g., diabetes mellitus.
Geovane Ribeiro Santos, Marcelo Rodrigues Cunha, Eduardo José Caldeira, Ewerton Alexandre Galdeano, Raphael Cruz Seabra Prudente, Clóvis Antonio Lopes Pinto   +5 more
doaj   +1 more source

Perilipin2/adipophilin and ApoA-1 team up to combat atherosclerosis [PDF]

Cardiovascular Research, 2015
This editorial refers to ‘Enhanced atheroprotection and lesion remodelling by targeting the foam cell and increasing plasma cholesterol acceptors’ by S.-H. Son et al. , pp. 294–304. Atherogenesis is characterized by accumulation of lipids and immune cells in the vascular wall.1 Modified low density lipoprotein (LDL) promotes the infiltration of ...
Benoit, Pourcet, Bart, Staels
openaire   +2 more sources

Thematic review series: Adipocyte Biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis

Journal of Lipid Research, 2007
The majority of eukaryotic cells synthesize neutral lipids and package them into cytosolic lipid droplets. In vertebrates, triacylglycerol-rich lipid droplets of adipocytes provide a major energy storage depot for the body, whereas cholesteryl ester-rich
Dawn L. Brasaemle
doaj   +1 more source

PPARα activators and fasting induce the expression of adipose differentiation-related protein in liver

Journal of Lipid Research, 2006
The adipose differentiation-related protein (ADFP)/adipophilin belongs to a family of PAT (for perilipin, ADFP, and TIP47) proteins that associate on the surface of lipid droplets (LDs). Except for LD association, a clear role for ADFP has not been found.
Knut Tomas Dalen, Stine M. Ulven, Borghild M. Arntsen, Karianne Solaas, Hilde I. Nebb   +4 more
doaj   +1 more source

Clinicopathological and Molecular Characteristics of Macroscopically Yellowish-Colored Chromophobe Renal Cell Carcinoma Compared to Non-Yellowish-Colored Chromophobe Renal Cell Carcinoma

Clinical Pathology, 2021
Each histological variant of renal cell tumors has a unique color. The yellowish color of clear cell renal cell carcinoma (CCRCC) is explained by the presence of intracytoplasmic lipid and glycogen accumulation. Color changes in CCRCC are correlated with
Fumiyoshi Kojima, Ibu Matsuzaki, Naoto Kuroda, Yurina Mikasa, Fidele Y Musangile, Ryuta Iwamoto, Yuichi Takahashi, Akiko Matsubara, Yasuo Kohjimoto, Isao Hara, Shin-ichi Murata   +10 more
doaj   +1 more source

Multiple functions encoded by the N-terminal PAT domain of adipophilin [PDF]

Journal of Cell Science, 2008
Adipophilin (ADPH), a member of the perilipin family of cytoplasmic lipid droplet (CLD)-binding proteins, is crucially dependent on triglyceride synthesis for stability. We have used cell lines expressing full-length or N-terminally modified forms of ADPH to investigate the role of the N-terminus in regulating ADPH stability and interactions with CLD ...
David J, Orlicky, Greg, Degala, Carrie, Greenwood, Elise S, Bales, Tanya D, Russell, James L, McManaman   +5 more
openaire   +2 more sources

Targeting to Intensify M2 Macrophage Polarization Ameliorate Podocyte Lipid Accumulation and Damage by Tea Polyphenols via Activating SIRT1 in the Aged Model Rats With DKD. [PDF]

Food Sci Nutr
Tea polyphenols (TP), as representative bioactive compounds of tea, promote SIRT1 activation, thereby enhancing the transformation of macrophages into the M2 phenotype, reducing renal inflammation, and ultimately alleviating podocyte lipid accumulation.
Chen S, Wang X, Li C, Cheng L, Lv C, Xue L, Zhang C, Li X, Li M, Guo Q, Zhao Y, Zhao H.   +11 more
europepmc   +2 more sources