Results 81 to 90 of about 173,062 (310)

Notch promotes neural lineage entry by pluripotent embryonic stem cells [PDF]

, 2006
A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells.
Smith, Austin G, Austin G Smith, Heavey Barry, Alexandra Benchoua, Benchoua, Alexandra, Smith, Austin,, Benchoua Alexandra, Sally Lowell, Smith Austin G, Lowell, Sally; id_orcid, Smith, Austin, G., Lowell Sally, Lowell, Sally, Heavey, Barry, Barry Heavey   +14 more
core   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Comparative characterization of mesenchymal stem cells from eGFP transgenic and non-transgenic mice

BMC Cell Biology, 2009
Background Adipose derived- and bone marrow-derived murine mesenchymal stem cells (mMSCs) may be used to study stem cell properties in an in vivo setting for the purposes of evaluating therapeutic strategies that may have clinical applications in the ...
Bunnell Bruce A, Ripoll Cynthia B
doaj   +1 more source

Therapeutic approach of adipose-derived mesenchymal stem cells in refractory peptic ulcer

Stem Cell Research & Therapy, 2021
Peptic ulcer is one of the most common gastrointestinal tract disorders worldwide, associated with challenges such as refractory morbidity, bleeding, interference with use of anticoagulants, and potential side effects associated with long-term use of ...
Mahshid Saleh, Amir Ali Sohrabpour, Mohammad Reza Mehrabi, Iman Seyhoun, Amir Abbas Vaezi   +4 more
doaj   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Biological effects of exosomes derived from 2D and 3D culture adipose stem cells on JEC Cell proliferation and migration

Frontiers in Bioengineering and Biotechnology
ObjectiveTo explore the biological impacts of exosomes derived from adipose stem cells cultured under two-dimensional (2D) and three-dimensional (3D) conditions on endometrial adenocarcinoma cells (JEC cells).Materials and methodsExosomes were isolated ...
Yifen Li, Gangwei Wang, Yi Zhang, Tao Xu, Xuefeng Jiang   +4 more
doaj   +1 more source

Early Translation of Adipose-Derived Cell Therapy for Cardiovascular Disease

Cell Transplantation, 2009
Over the past decade, cell therapy has emerged as a new approach to reversing myocardial ischemia. Several types of adult stem cells have been studied in both preclinical and clinical conditions for this purpose: bone marrow cells, circulating cells, and
Ricardo Sanz-Ruiz, Eugenia Fernández-Santos, Marta Domínguez-Muñoa, Radoslaw Parma, Adolfo Villa, Lucía Fernández, Pedro L. Sánchez, Francisco Fernández-Avilés   +7 more
doaj   +1 more source

Review of the adipose derived stem cell secretome

Biochimie, 2013
Recent advances in protein detection and analysis have lead to multiple in depth studies that analyze the adipose-derived stem cell (ASC) secretome. These studies differ significantly in their methods of secretome preparation and analysis. Most of them use a pro-differentiation or pro-inflammatory stimulus to observe differential expression of secreted
unknown ( host institution ), Kapur, Sahil K. ( author )   +1 more
openaire   +3 more sources

Absorption and Tensility of Bioactive Sutures Prepared for Cell Transplantation [PDF]

, 2013
Biodegradable scaffolds are widely used to transplant stem cells into various tissues. Recent studies showed that living stem cells can be attached to the surface of absorbable sutures in vitro.
Vácz, Gabriella, Tamás Szabó, Horváthy, Dénes, Lacza, Zsombor, Renner, Károly, Dénes Horváthy, Szabó, Tamás, Kinga Vajda, Vajda Kinga,, Vajda, Kinga, Gabriella Vácz, Renner, Károly Péter, Károly Renner, Balázs Sándor, Sándor, Balázs, Zsombor Lacza   +15 more
core   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source