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Adipose tissue remodeling: its role in energy metabolism and metabolic disorders

Frontiers in Endocrinology, 2016
The adipose tissue is a central metabolic organ in the regulation of whole-body energy homeostasis. The white adipose tissue (WAT) functions as a key energy reservoir for other organs, whereas the brown adipose tissue (BAT) accumulates lipids for cold ...
Sung Sik eChoe, Jin Young eHuh, In Jae eHwang, Jong In eKim, Jae Bum eKim   +4 more
doaj   +2 more sources

Thermoneutral housing promotes hepatic steatosis in standard diet-fed C57BL/6N mice, with a less pronounced effect on NAFLD progression upon high-fat feeding

Frontiers in Endocrinology, 2023
IntroductionNon-alcoholic fatty liver disease (NAFLD) can progress to more severe stages, such as steatohepatitis and fibrosis. Thermoneutral housing together with high-fat diet promoted NAFLD progression in C57BL/6J mice.
Olga Horakova, Gabriella Sistilli, Gabriella Sistilli, Veronika Kalendova, Veronika Kalendova, Kristina Bardova, Marko Mitrovic, Marko Mitrovic, Tomas Cajka, Ilaria Irodenko, Petra Janovska, Karoline Lackner, Jan Kopecky, Martin Rossmeisl   +13 more
doaj   +1 more source

Adipose tissue-specific ablation of PGC-1β impairs thermogenesis in brown fat

Disease Models & Mechanisms, 2022
Impaired thermogenesis observed in mice with whole-body ablation of peroxisome proliferator-activated receptor-γ coactivator-1β (PGC-1β; officially known as PPARGC1B) may result from impaired brown fat (brown adipose tissue; BAT) function, but other ...
Jiří Funda, Josep A. Villena, Kristina Bardova, Katerina Adamcova, Illaria Irodenko, Pavel Flachs, Ivana Jedlickova, Eliska Haasova, Martin Rossmeisl, Jan Kopecky, Petra Janovska   +10 more
doaj   +1 more source

Epicardial adipose tissue in contemporary cardiology

Nature Reviews Cardiology, 2022
Interest in epicardial adipose tissue (EAT) is growing rapidly, and research in this area appeals to a broad, multidisciplinary audience. EAT is unique in its anatomy and unobstructed proximity to the heart and has a transcriptome and secretome very ...
G. Iacobellis
semanticscholar   +1 more source

Adipose tissue aging: mechanisms and therapeutic implications

Cell Death and Disease, 2022
Adipose tissue, which is the crucial energy reservoir and endocrine organ for the maintenance of systemic glucose, lipid, and energy homeostasis, undergoes significant changes during aging.
M. Ou, Hao Zhang, Poh-ching Tan, Shuangbai Zhou, Qing-Feng Li   +4 more
semanticscholar   +1 more source

Obesity, Adipose Tissue and Vascular Dysfunction.

Circulation Research, 2021
Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity are strongly associated with comorbidities such as hypertension and insulin resistance, which collectively contribute to the development of cardiovascular diseases ...
M. Koenen, M. Hill, P. Cohen, J. Sowers
semanticscholar   +1 more source

Exercise Training as Therapeutic Approach in Cancer Cachexia: A Review of Potential Anti-inflammatory Effect on Muscle Wasting

Frontiers in Physiology, 2021
Cachexia is a multifactorial inflammatory syndrome with high prevalence in cancer patients. It is characterized by a metabolic chaos culminating in drastic reduction in body weight, mainly due to skeletal muscle and fat depletion. Currently, there is not
Luana G. Leal, Luana G. Leal, Magno A. Lopes, Sidney B. Peres, Miguel L. Batista, Miguel L. Batista   +5 more
doaj   +1 more source

Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus

Adipocyte, 2021
Mammalian adipose tissue can be divided into two major types, namely, white adipose tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function of WAT is to store excess energy in the form of triglycerides, while BAT is a ...
Long Cheng, Jingkang Wang, Hongyu Dai, Yuhui Duan, Yongcheng An, Lu Shi, Yinglan Lv, Huimin Li, Chen Wang, Quantao Ma, Yaqi Li, Pengfei Li, Haifeng Du, Baosheng Zhao   +13 more
semanticscholar   +1 more source

Gene Expression Signature in Adipose Tissue of Acromegaly Patients. [PDF]

, 2014
To study the effect of chronic excess growth hormone on adipose tissue, we performed RNA sequencing in adipose tissue biopsies from patients with acromegaly (n = 7) or non-functioning pituitary adenomas (n = 11).
Barkan, Ariel L, Bridges, Dave, Chandler, William F, Hochberg, Irit, Saltiel, Alan R, Tran, Quynh T   +5 more
core   +8 more sources

Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease

Experimental and Molecular Medicine, 2021
Obesity: tracing the inflammation underlying liver disease A deeper understanding of the molecular processes underlying dysfunctional fatty-acid metabolism in nonalcoholic fatty liver disease (NAFLD) could help protect patients from severe liver damage ...
Jin Young Huh, Alan R. Saltiel
doaj   +1 more source