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Adipose Tissue Inflammation

Cells, 2023
In recent decades, obesity has become one of the most common metabolic diseases [...]
Javier Gómez-Ambrosi
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Targeting adipose tissue [PDF]

Diabetology & Metabolic Syndrome, 2012
Two different types of adipose tissues can be found in humans enabling them to respond to starvation and cold: white adipose tissue (WAT) is generally known and stores excess energy in the form of triacylglycerol (TG), insulates against cold, and serves ...
Haas Bodo, Schlinkert Paul, Mayer Peter, Eckstein Niels   +3 more
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Thermoneutral housing promotes hepatic steatosis in standard diet-fed C57BL/6N mice, with a less pronounced effect on NAFLD progression upon high-fat feeding

Frontiers in Endocrinology, 2023
IntroductionNon-alcoholic fatty liver disease (NAFLD) can progress to more severe stages, such as steatohepatitis and fibrosis. Thermoneutral housing together with high-fat diet promoted NAFLD progression in C57BL/6J mice.
Olga Horakova, Gabriella Sistilli, Gabriella Sistilli, Veronika Kalendova, Veronika Kalendova, Kristina Bardova, Marko Mitrovic, Marko Mitrovic, Tomas Cajka, Ilaria Irodenko, Petra Janovska, Karoline Lackner, Jan Kopecky, Martin Rossmeisl   +13 more
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Adipose tissue-specific ablation of PGC-1β impairs thermogenesis in brown fat

Disease Models & Mechanisms, 2022
Impaired thermogenesis observed in mice with whole-body ablation of peroxisome proliferator-activated receptor-γ coactivator-1β (PGC-1β; officially known as PPARGC1B) may result from impaired brown fat (brown adipose tissue; BAT) function, but other ...
Jiří Funda, Josep A. Villena, Kristina Bardova, Katerina Adamcova, Illaria Irodenko, Pavel Flachs, Ivana Jedlickova, Eliska Haasova, Martin Rossmeisl, Jan Kopecky, Petra Janovska   +10 more
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A pyrexic effect of FGF21 independent of energy expenditure and UCP1

Molecular Metabolism, 2021
Objective: Administration of FGF21 to mice reduces body weight and increases body temperature. The increase in body temperature is generally interpreted as hyperthermia, i.e.
Petr Zouhar, Petra Janovska, Sara Stanic, Kristina Bardova, Jiri Funda, Blanka Haberlova, Birgitte Andersen, Martin Rossmeisl, Barbara Cannon, Jan Kopecky, Jan Nedergaard   +10 more
doaj   +1 more source

Adipose tissue macrophages in aging-associated adipose tissue function [PDF]

The Journal of Physiological Sciences, 2021
"Inflammaging" refers to the chronic, low-grade inflammation that characterizes aging. Aging, like obesity, is associated with visceral adiposity and insulin resistance. Adipose tissue macrophages (ATMs) have played a major role in obesity-associated inflammation and insulin resistance. Macrophages are elevated in adipose tissue in aging.
Lu, Bangchao, Huang, Liang, Cao, Juan, Li, Lingling, Wu, Wenhui, Chen, Xiaolin, Ding, Congzhu   +6 more
openaire   +2 more sources

Impairment of adrenergically-regulated thermogenesis in brown fat of obesity-resistant mice is compensated by non-shivering thermogenesis in skeletal muscle

Molecular Metabolism, 2023
Objective: Non-shivering thermogenesis (NST) mediated by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) can be activated via the adrenergic system in response to cold or diet, contributing to both thermal and energy homeostasis.
Petra Janovska, Petr Zouhar, Kristina Bardova, Jakub Otahal, Marek Vrbacky, Tomas Mracek, Katerina Adamcova, Lucie Lenkova, Jiri Funda, Tomas Cajka, Zdenek Drahota, Sara Stanic, Arild C. Rustan, Olga Horakova, Josef Houstek, Martin Rossmeisl, Jan Kopecky   +16 more
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Exercise Training as Therapeutic Approach in Cancer Cachexia: A Review of Potential Anti-inflammatory Effect on Muscle Wasting

Frontiers in Physiology, 2021
Cachexia is a multifactorial inflammatory syndrome with high prevalence in cancer patients. It is characterized by a metabolic chaos culminating in drastic reduction in body weight, mainly due to skeletal muscle and fat depletion. Currently, there is not
Luana G. Leal, Luana G. Leal, Magno A. Lopes, Sidney B. Peres, Miguel L. Batista, Miguel L. Batista   +5 more
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Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

Nature Communications, 2020
Lipid droplets are organelles that regulate lipid metabolism but if organellar contacts play a role during lipolysis is unclear. Here, the authors show that peroxisomes and peroxisomal protein PEX5 play pivotal roles in the spatial and temporal ...
Jinuk Kong, Yul Ji, Yong Geun Jeon, Ji Seul Han, Kyung Hee Han, Jung Hyun Lee, Gung Lee, Hagoon Jang, Sung Sik Choe, Myriam Baes, Jae Bum Kim   +10 more
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Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease

Experimental and Molecular Medicine, 2021
Obesity: tracing the inflammation underlying liver disease A deeper understanding of the molecular processes underlying dysfunctional fatty-acid metabolism in nonalcoholic fatty liver disease (NAFLD) could help protect patients from severe liver damage ...
Jin Young Huh, Alan R. Saltiel
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