Results 11 to 20 of about 4,280,291 (335)
Adipose tissue macrophages in aging-associated adipose tissue function [PDF]
The Journal of Physiological Sciences, 2021 "Inflammaging" refers to the chronic, low-grade inflammation that characterizes aging. Aging, like obesity, is associated with visceral adiposity and insulin resistance. Adipose tissue macrophages (ATMs) have played a major role in obesity-associated inflammation and insulin resistance. Macrophages are elevated in adipose tissue in aging.
Lu, Bangchao +6 more
openaire +2 more sources
Molecular Metabolism, 2023 Objective: Non-shivering thermogenesis (NST) mediated by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) can be activated via the adrenergic system in response to cold or diet, contributing to both thermal and energy homeostasis.
Petra Janovska +16 more
doaj +1 more source
Obesity, Adipose Tissue and Vascular Dysfunction.
Circulation Research, 2021 Cardiovascular diseases are the leading cause of death worldwide. Overweight and obesity are strongly associated with comorbidities such as hypertension and insulin resistance, which collectively contribute to the development of cardiovascular diseases ...
M. Koenen, M. Hill, P. Cohen, J. Sowers
semanticscholar +1 more source
Adipose tissue aging: mechanisms and therapeutic implications
Cell Death and Disease, 2022 Adipose tissue, which is the crucial energy reservoir and endocrine organ for the maintenance of systemic glucose, lipid, and energy homeostasis, undergoes significant changes during aging.
M. Ou +4 more
semanticscholar +1 more source
Frontiers in Physiology, 2021 Cachexia is a multifactorial inflammatory syndrome with high prevalence in cancer patients. It is characterized by a metabolic chaos culminating in drastic reduction in body weight, mainly due to skeletal muscle and fat depletion. Currently, there is not
Luana G. Leal +5 more
doaj +1 more source
Nutrition and Metabolism, 2022 Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining health and homeostasis. Although white adipose tissue and brown adipose tissue are currently considered key endocrine organs, they differ functionally and ...
Sabrina Azevedo Machado +6 more
semanticscholar +1 more source
Adipose Tissue Inflammation and Metabolic Dysfunction in Obesity.
American Journal of Physiology - Cell Physiology, 2020 Several lines of preclinical and clinical research have confirmed that chronic low-grade inflammation of adipose tissue is mechanistically linked to metabolic disease and organ tissue complications in the overweight and obese organism.
Tatsuo Kawai, M. Autieri, R. Scalia
semanticscholar +1 more source
Adipocyte, 2021 Mammalian adipose tissue can be divided into two major types, namely, white adipose tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function of WAT is to store excess energy in the form of triglycerides, while BAT is a ...
Long Cheng +13 more
semanticscholar +1 more source
Nature Communications, 2020 Lipid droplets are organelles that regulate lipid metabolism but if organellar contacts play a role during lipolysis is unclear. Here, the authors show that peroxisomes and peroxisomal protein PEX5 play pivotal roles in the spatial and temporal ...
Jinuk Kong +10 more
doaj +1 more source
Experimental and Molecular Medicine, 2021 Obesity: tracing the inflammation underlying liver disease A deeper understanding of the molecular processes underlying dysfunctional fatty-acid metabolism in nonalcoholic fatty liver disease (NAFLD) could help protect patients from severe liver damage ...
Jin Young Huh, Alan R. Saltiel
doaj +1 more source