Results 41 to 50 of about 4,507,088 (388)
Frontiers in Immunology, 2018 Adipose tissue is a metabolic organ that plays a central role in controlling systemic energy homeostasis. Compelling evidence indicates that immune system is closely linked to healthy physiologic functions and pathologic dysfunction of adipose tissue. In
Yoon Jeong Park +8 more
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FAM13A and POM121C are candidate genes for fasting insulin: functional follow-up analysis of a genome-wide association study [PDF]
, 2018 Aims/hypothesis: By genome-wide association meta-analysis, 17 genetic loci associated with fasting serum insulin (FSI), a marker of systemic insulin resistance, have been identified. To define potential culprit genes in these loci, in a cross-sectional
Arner, Peter +6 more
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Lipids in Health and Disease, 2020 Obesity exhibits a correlation with metabolic inflammation and endoplasmic reticulum stress, promoting the progression of metabolic disease such as diabetes, hyperlipidemia, hyperuricemia and so on.
Yunjia Li, Ke Yun, Runqing Mu
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Stem Cell Research & Therapy, 2021 Background In human subcutaneous adipose tissue, the superficial fascia distinguishes superficial and deep microenvironments showing extensions called retinacula cutis.
Leandra Santos Baptista +7 more
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LLC tumor cells-derivated factors reduces adipogenesis in co-culture system
Heliyon, 2018 Cancer cachexia (CC) is a multifactorial syndrome with an unknown etiology. The primary symptom is the progressive reduction of the body weight. Recently, down-regulation of adipogenic and lipogenic genes were demonstrated to be early affected during ...
Magno Alves Lopes +4 more
doaj +1 more source
Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation
Nature Communications, 2017 VLDLR regulates cellular lipoprotein uptake and storage. Here, the authors show that VLDLR, expressed on adipose tissue macrophages, is upregulated in obesity and promotes adipose tissue inflammation by upregulating ceramide production and facilitating ...
Kyung Cheul Shin +10 more
doaj +1 more source
Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress [PDF]
, 2018 Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress, and lipotoxicity.We hypothesize that an increase in the inflammatory adipokine NOV decreases antioxidant Heme Oxygenase 1 (HO- 1)
Abraham, Nader G. +13 more
core +1 more source
Extracellular vesicles from adipose tissue - a potential role in obesity and type 2 diabetes? [PDF]
, 2017 Adipose tissue plays a key role in the development of insulin resistance and its pathological sequelae such as type 2 diabetes and non-alcoholic fatty liver disease. Dysfunction in the adipose tissue response to storing excess fatty acids as triglyceride
Freeman, Dilys J. +2 more
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Obesity, Bioactive Lipids, and Adipose Tissue Inflammation in Insulin Resistance
Nutrients, 2020 Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes. The exact mechanism by which adipose tissue induces insulin resistance is still unclear.
Iwona Kojta +2 more
semanticscholar +1 more source
Imaging of Adipose Tissue [PDF]
, 2014 Adipose tissue is an endocrine organ that specializes in lipid metabolism and is distributed throughout the body in distinct white adipose tissue (WAT) and brown adipose tissue (BAT) depots. These tissues have opposing roles in lipid metabolism with WAT storing excessive caloric intake in the form of lipid, and BAT burning lipid through nonshivering ...
Ryan Berry +5 more
openaire +3 more sources