Results 41 to 50 of about 4,454,068 (344)

A neuronal relay mediates a nutrient responsive gut/fat body axis regulating energy homeostasis in adult Drosophila [PDF]

, 2019
The control of systemic metabolic homeostasis involves complex inter-tissue programs that coordinate energy production, storage, and consumption, to maintain organismal fitness upon environmental challenges.
Bauer, Christin, Cordero, Julia B., Kruspig, Bjorn, Maddocks, Oliver D.K., Murphy, Daniel J., Scopelliti, Alessandro, Vidal, Marcos, Yu, Yachuan, Zhang, Tong   +8 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

FEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai, Richard J. McDowell, Robert J. Lucas   +2 more
wiley   +1 more source

Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection [PDF]

, 2015
International audienceTwo of the crucial aspects of human immunodeficiency virus (HIV) infection are (i) viral persistence in reservoirs (precluding viral eradication) and (ii) chronic inflammation (directly associated with all-cause morbidities in ...
Avettand-Fenoël, Véronique, Benoist, Stéphane, Bourgeois, Christine, Béréziat, Véronique, Capeau, Jacqueline, Cosma, Antonio, Damouche, Abderaouf, David, Ludivine, Dejucq-Rainsford, Nathalie, Dereuddre-Bosquet, Nathalie, Favier, Benoît, Ghosn, Jade, Gommet, Céline, Huot, Nicolas, Lambotte, Olivier, Lazure, Thierry, Le Grand, Roger, Martinez, Valérie, Mélard, Adeline, Müller-Trutwin, Michaela, Noel, Nicolas, Pourcher, Guillaume, Rouzioux, Christine, Satie, Anne-Pascale, Vaslin, Bruno   +24 more
core   +6 more sources

Identification of a mesenchymal progenitor cell hierarchy in adipose tissue

Science, 2019
A singular focus on fat Fatty tissue can expand in two ways: through increases in the size of individual adipocytes or through increases in the number of adipocytes.
David Merrick, Alexander Sakers, Zhazira Irgebay, Chihiro Okada, C. Calvert, M. Morley, I. Percec, P. Seale   +7 more
semanticscholar   +1 more source

Adipose tissue and liver [PDF]

Journal of Applied Physiology, 2018
Adipose tissue and liver are central tissues in whole body energy metabolism. Their composition, structure, and function can be noninvasively imaged using a variety of measurement techniques that provide a safe alternative to an invasive biopsy. Imaging of adipose tissue is focused on quantitating the distribution of adipose tissue in subcutaneous and
openaire   +3 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Cross talk between adipose tissue and placenta in obese and gestational diabetes mellitus pregnancies via exosomes [PDF]

, 2017
Obesity is an important public health issue worldwide, where it is commonly associated with the development of metabolic disorders, especially insulin resistance (IR).
Agustin Gutierrez, Jaime, Freeman, Dilys Jane, Jayabalan, Nanthini, Lappas, Martha, Leiva, Andrea, Nair, Soumyalekshmi, Nuzhat, Zarin, Rice, Gregory E., Salomon, Carlos, Sanhueza, Carlos, Sobrevia, Luis, Zúñiga, Felipe A.   +11 more
core   +2 more sources

Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications

International Journal of Molecular Sciences, 2019
Obesity is a critical risk factor for the development of type 2 diabetes (T2D), and its prevalence is rising worldwide. White adipose tissue (WAT) has a crucial role in regulating systemic energy homeostasis. Adipose tissue expands by a combination of an
M. Longo, Federica Zatterale, Jamal Naderi, Luca Parrillo, P. Formisano, G. A. Raciti, F. Beguinot, C. Miele   +7 more
semanticscholar   +1 more source

Perivascular Adipose Tissue [PDF]

, 2019
Contractility of small arteries determines systemic blood pressure, so the microvasculature is often invoked as a therapeutic target for hypertension and its consequences. This is especially the case for obesity-related hypertension which is characterized by small artery dysfunction.
Javed, Saad, Alakrawi, Mariam, Greenstein, Adam S.   +2 more
openaire   +2 more sources