Results 51 to 60 of about 442,668 (315)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Adipose derived tissue engineered heart valve [PDF]

, 2015
Introduction: A major challenge associated with heart valve tissue engineering is the in vitro creation of mature tissue structures compliant with native valve functionality.
Baaijens, FPT Frank, Beer, G M, Driessen - Mol, A., Hoerstrup, S., Beer, G.M., Baaijens, Frank P T, Baaijens, F.P.T., Weber, B., Hoerstrup, S P, Driessen-Mol, Anita, Frese, Laura, Frese, L., Driessen-Mol, A Anita, Weber, Benedikt, Beer, Gertrude M, Sanders, B Bart, Hoerstrup, S Simon, Sanders, Bart, Sanders, B.   +18 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Faster postnatal decline in hepatic erythropoiesis than granulopoiesis in human newborns

Frontiers in Pediatrics
BackgroundDuring human foetal development, the liver is the primary site of blood cell production, but this activity declines in the third trimester and postnatally as haematopoiesis shifts to bone marrow.
Petra Janovska, Kristina Bardova, Zuzana Prouzova, Zuzana Prouzova, Ilaria Irodenko, Tatyana Kobets, Eliska Haasova, Eliska Haasova, Lenka Steiner Mrazova, Lenka Steiner Mrazova, Viktor Stranecky, Stanislav Kmoch, Martin Rossmeisl, Petr Zouhar, Jan Kopecky   +14 more
doaj   +1 more source

Estimation of CT-derived abdominal visceral and subcutaneous adipose tissue depots from anthropometry in Europeans, South Asians and African Caribbeans [PDF]

, 2013
Background South Asians and African Caribbeans experience more cardiometabolic disease than Europeans. Risk factors include visceral (VAT) and subcutaneous abdominal (SAT) adipose tissue, which vary with ethnicity and are difficult to quantify using ...
Willis Joseph, Hughes, AD, Ian F. Godsland (212035), Peter Whincup (20840), Peter Whincup, Tillin, T, Therese Tillin, Joseph Willis, Sophie V. Eastwood (459934), Tillin Therese, Andrew Wright (459935), Nita Forouhi (459938), Nita Forouhi, Andrew Wright, Joseph Willis (459937), Eastwood Sophie V., Nishi Chaturvedi, Wright, A, Forouhi, N, Ian F Godsland, Nishi Chaturvedi (130777), Hughes Alun D., Eastwood, SV, Wright Andrew, Chaturvedi, N, Whincup, P, John Heasman (459936), Whincup Peter, Godsland, IF, Chaturvedi Nishi, Sophie V Eastwood, Alun D Hughes, Heasman John, Heasman, J, John Heasman, Forouhi Nita, Willis, J, Alun D. Hughes (395075), Therese Tillin (130770), Godsland Ian F.   +39 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

The Impact of the Adipose Organ Plasticity on Inflammation and Cancer Progression

Cells, 2019
Obesity is characterized by chronic and low-grade systemic inflammation, an increase of adipose tissue, hypertrophy, and hyperplasia of adipocytes.
Luís Henrique Corrêa, Gabriella Simões Heyn, Kelly Grace Magalhaes   +2 more
doaj   +1 more source

Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats [PDF]

, 2012
Low-carbohydrate, high-fat (LC-HF) diets are popular for inducing weight loss in overweighed adults. Adaptive thermogenesis increased by specific effects of macronutrients on energy expenditure has been postulated to induce this weight loss.
Bidlingmaier, Martin, Korbinian Pieper (158350), Müller, H.H., Brigitte Mauracher, William Abplanalp (158346), Marc Slawik (152756), Bidlingmaier, M., Ramisch, Juliane, Mauracher, B., Tschöp Matthias H., Mauracher, Brigitte, Ramisch, J., Bidlingmaier Martin, Pieper, Korbinian, Slawik, Marc, Pieper, K., Juliane Ramisch, Maximilian Bielohuby (158339), Bielohuby Maximilian, Müller Hans-Helge, Matthias H Tschöp, Korbinian Pieper, Tschöp, Matthias H., Matthias J Betz, Matthias J. Betz (158336), Beuschlein, Felix, Abplanalp William, Felix Beuschlein, Matthias H. Tschöp (158357), Abplanalp, William, Pieper Korbinian, Brigitte Mauracher (158342), Beuschlein, F., Hans-Helge Müller (158349), Bielohuby, M., Tschöp, M.H., Bielohuby, Maximilian, Müller, Hans-Helge, William Abplanalp, Mauracher Brigitte, Betz, Matthias J., Marc Slawik, Martin Bidlingmaier (150187), Abplanalp, W., Martin Bidlingmaier, Juliane Ramisch (158353), Betz, M.J., Beuschlein Felix, Slawik, M., Maximilian Bielohuby, Slawik Marc, Ramisch Juliane, Hans-Helge Müller, Felix Beuschlein (158361), Betz Matthias J.   +54 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source