Results 51 to 60 of about 4,280,291 (335)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Adipose tissue is a critical regulator of osteoarthritis

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Obesity is a primary risk factor for osteoarthritis, involving complex interactions among the metabolic, biomechanical, and inflammatory factors caused by increased adiposity.
K. Collins, K. L. Lenz, E. N. Pollitt, D. Ferguson, Irina Hutson, Luke E. Springer, A. Oestreich, Ruhang Tang, Yun-Rak Choi, G. Meyer, S. Teitelbaum, C. Pham, Charles A. Harris, F. Guilak   +13 more
semanticscholar   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice

Nature Communications, 2023
Adipose tissue invariant natural killer T (iNKT) cells are a crucial cell type for adipose tissue homeostasis in obese animals. However, heterogeneity of adipose iNKT cells and their function in adipocyte turnover are not thoroughly understood.
Sang Mun Han, Eun Seo Park, Jeu Park, Hahn Nahmgoong, Yoon Ha Choi, Jiyoung Oh, Kyung Min Yim, Won Taek Lee, Yun Kyung Lee, Yong Geun Jeon, Kyung Cheul Shin, Jin Young Huh, Sung Hee Choi, Jiyoung Park, Jong Kyoung Kim, Jae Bum Kim   +15 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Differential regulation of gene co-expression modules in muscles and liver of preterm newborns

Frontiers in Cell and Developmental Biology
BackgroundNewborns undergo rapid metabolic and organ adaptations after birth, which are compromised in premature newborns, leading to adverse health outcomes.
Petra Janovska, Tatyana Kobets, Lenka Steiner Mrazova, Lenka Steiner Mrazova, Michaela Svobodova, Marketa Tesarova, Pavel Kopecky, Petr Zouhar, Martin Rossmeisl, Viktor Stranecky, Stanislav Kmoch, Jan Kopecky   +11 more
doaj   +1 more source

Adipose tissue estimation of foraging and nesting green turtles Chelonia mydas using bioelectrical impedance analysis

Endangered Species Research, 2023
Adipose tissue is the main energy store in sea turtles and fluctuates in response to dietary conditions and external stressors. Monitoring programmes commonly use body condition indices (BCIs) to infer the nutritional and health status of sea turtle ...
S Kophamel, LC Ward, D Mendez, E Ariel, I Bell, E Shum, SL Munns   +6 more
doaj   +1 more source

Identification of a mesenchymal progenitor cell hierarchy in adipose tissue

Science, 2019
A singular focus on fat Fatty tissue can expand in two ways: through increases in the size of individual adipocytes or through increases in the number of adipocytes.
David Merrick, Alexander Sakers, Zhazira Irgebay, Chihiro Okada, C. Calvert, M. Morley, I. Percec, P. Seale   +7 more
semanticscholar   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source