Immune cell labelling and tracking: implications for adoptive cell transfer therapies [PDF]
EJNMMI Radiopharmacy and Chemistry, 2021 Background The understanding of the role of different immune cell subsets that infiltrate tumors can help researchers in developing new targeted immunotherapies to reactivate or reprogram them against cancer.
Filippo Galli +5 more
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Improving Tumor Retention of Effector Cells in Adoptive Cell Transfer Therapies by Magnetic Targeting [PDF]
Pharmaceutics, 2020 Adoptive cell transfer therapy is a promising anti-tumor immunotherapy in which effector immune cells are transferred to patients to treat tumors. However, one of its main limitations is the inefficient trafficking of inoculated effector cells to the ...
Laura Sanz-Ortega +2 more
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Adoptive cell transfer: new perspective treatment in veterinary oncology [PDF]
Acta Veterinaria Scandinavica, 2018 Cancer immunotherapy is recently considered the most promising treatment for human patients with advanced tumors and could be effectively combined with conventional therapies such as chemotherapy or radiotherapy.
Joanna Katarzyna Bujak +3 more
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Anti-tumor efficacy of a combination therapy with PD-L1 targeted alpha therapy and adoptive cell transfer of PD-1 deficient melanoma-specific human T-lymphocytes [PDF]
OncoImmunology, 2021 The optimization of adoptive transfer approaches of anti-tumor T cells requires both the functional improvement of the injected T cells and the modulation of the tumor microenvironment, favoring the recruitment of these T cells and their activation.
L Marotte +13 more
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Metabolic radiolabeling and in vivo PET imaging of cytotoxic T lymphocytes to guide combination adoptive cell transfer cancer therapy [PDF]
Journal of Nanobiotechnology, 2021 Background Adoptive T cell transfer-based immunotherapy yields unsatisfactory results in the treatment of solid tumors, partially owing to limited tumor infiltration and the immunosuppressive microenvironment in solid tumors.
Dehua Lu +8 more
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Frontiers in Immunology, 2021 During the last decade, many studies have demonstrated the role of CMV specific T-cell immune response on controlling CMV replication and dissemination. In fact, it is well established that transplanted patients lacking CMV-specific T-cell immunity have ...
Estéfani García-Ríos +3 more
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Fibrinogen-like protein 2/fibroleukin induces long-term allograft survival in a rat model through regulatory B cells. [PDF]
PLoS ONE, 2015 We previously described that in a rat model of heart transplantation tolerance was dependent on CD8+CD45RClow Tregs that over-expressed fibrinogen-like protein 2 (FGL2)/fibroleukin. Little is known on the immunoregulatory properties of FGL2.
Séverine Bézie +10 more
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Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation. [PDF]
PLoS ONE, 2012 Both nature and induced regulatory T (Treg) lymphocytes are potent regulators of autoimmune and allergic disorders. Defects in endogenous Treg cells have been reported in patients with allergic asthma, suggesting that disrupted Treg cell-mediated ...
Wei Xu +14 more
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A novel and effective cancer immunotherapy mouse model using antigen-specific B cells selected in vitro. [PDF]
PLoS ONE, 2014 Immunotherapies such as adoptive transfer of T cells or natural killer cells, or monoclonal antibody (MoAb) treatment have recently been recognized as effective means to treat cancer patients.
Tatsuya Moutai +3 more
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Frontiers in Immunology, 2023 Efficient intratumoral infiltration of adoptively transferred cells is a significant barrier to effectively treating solid tumors with adoptive cellular transfer (ACT) therapies. Our recent forward genetic, whole-genome screen identified T cell-intrinsic
Vianca V. Vianzon +4 more
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