Journal of Hematology & Oncology, 2019 Background Allogeneic hematopoietic stem cell transplantation (HSCT) can expose patients to a transient but marked immunosuppression, during which viral infections are an important cause of morbidity and mortality.
Theresa Kaeuferle +4 more
doaj +2 more sources
Neoantigen Identification and Response to Adoptive Cell Transfer in Anti-PD-1 Naïve and Experienced Patients with Metastatic Melanoma. [PDF]
Clin Cancer Res, 2022 PURPOSE Immune checkpoint blockade (ICB) agents and adoptive cell transfer (ACT) of tumor infiltrating lymphocytes (TIL) are prominent immunotherapies used for the treatment of advanced melanoma.
Levi ST +23 more
europepmc +2 more sources
Harnessing the Anti-Tumor Mediators in Mast Cells as a New Strategy for Adoptive Cell Transfer for Cancer. [PDF]
Front Oncol, 2022 The emergence of cancer immunotherapies utilizing adoptive cell transfer (ACT) continues to be one of the most promising strategies for cancer treatment. Mast cells (MCs) which occur throughout vascularized tissues, are most commonly associated with Type
Fereydouni M +6 more
europepmc +2 more sources
Generation of neoantigen-specific T cells for adoptive cell transfer for treating head and neck squamous cell carcinoma. [PDF]
Oncoimmunology, 2021 Adoptive cell therapy using TCR-engineered T cells (TCR-T cells) represents a promising strategy for treating relapsed and metastatic cancers. We previously established methods to identify neoantigen-specific TCRs based on patients’ PBMCs.
Wei T +13 more
europepmc +2 more sources
Adoptive Cell Transfer of Regulatory T Cells Exacerbates Hepatic Steatosis in High-Fat High-Fructose Diet-Fed Mice. [PDF]
Front Immunol, 2020 Background and Aims: Non-alcoholic steatohepatitis (NASH) is a multisystem condition, involving the liver, adipose tissue, and immune system. Regulatory T (Treg) cells are a subset of T cells that exert an immune-controlling effect.
Van Herck MA +9 more
europepmc +2 more sources
Adoptive Cell Transfer: Is it a Promising Immunotherapy for Colorectal Cancer? [PDF]
Theranostics, 2018 The last decade has witnessed significant advances in the adoptive cell transfer (ACT) technique, which has been appreciated as one of the most promising treatments for patients with cancer.
Fan J +5 more
europepmc +2 more sources
Adoptive cell transfer as personalized immunotherapy for human cancer. [PDF]
Science, 2015 Rosenberg SA, Restifo NP.
europepmc +2 more sources
The challenges of adoptive cell transfer in the treatment of human renal cell carcinoma. [PDF]
Cancer Immunol Immunother, 2019 Strizova Z, Bartunkova J, Smrz D.
europepmc +2 more sources
BMB Reports, 2021 Adoptive cell transfer (ACT), a form of cell-based immunotherapy that eliminates cancer by restoring and strengthening the body’s immune system, has revolutionized cancer treatment.
Yeonsun Hong, In‐San Kim
semanticscholar +1 more source
Outcomes of Adoptive Cell Transfer With Tumor-infiltrating Lymphocytes for Metastatic Melanoma Patients With and Without Brain Metastases. [PDF]
J Immunother, 2018 Brain metastases cause significant morbidity and mortality in patients with metastatic melanoma. Although adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TIL) can achieve complete and durable remission of advanced cutaneous melanoma, the
Mehta GU +9 more
europepmc +2 more sources